Archives

Protein Phase Separation in Immunology and Aging

IRB Special Seminar Dr. Gea Silvia Sofia Cereghetti Centre for Misfolding Diseases, Department of Chemistry University of Cambridge Tuesday, 10 September 2024 at 11 am  Bios+ Seminar Room  

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms

A paper published in the journal “Nature Communications” by the Sugimoto, Shinohara and Cejka laboratories shows how Sae2 regulates the nuclease activity of the MRX complex to initiate Homologous Recombination mediated rep​air of DNA breaks. Bellinzona – July 26 2024 – DNA double-strand breaks (DSBs) are a threat for genome integrity and cell survival and […]

Immunity and Metabolism go viral

IRB Special Seminar Dr. Samuel Nobs Department of Systems Immunology, Weizmann Institute of Science Wednesday, 28 August 2024 at 1.30 pm Bios+ Seminar Room    

HLTF removes Cas9 from DNA breaks

A paper published in the journal “Nature Communications” by the Cejka laboratory shows that the HLTF, a protein known to remodel replication forks, can unexpectedly dislocate Cas9 from the DNA after cleavage to initiate DNA double-stranded break repair. Bellinzona – July 10 2024 – During gene editing, the repair of DNA double-stranded breaks generated with […]

Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition

A new study published by the Grassi laboratory and collaborators in “Cell Reports Medicine” demonstrates that releasing the inhibitory effect of adenosine-triphosphate (ATP) on secretory IgA production in the gut protects from enteropathy and restores growth in malnourished newborns Bellinzona – July 5 2024 –  Living in impoverished environments is the cause of stunting for […]

From drug design to protein design

IRB Special Seminar Dr. Raffaele Passannanti Faculty of Sciences of the Scuola Normale Superiore (IT) Thursday,  4 July 2024 at 12 pm Bios+ Seminar Room   Contact: Dr. Andrea Cavalli