Archives

Fluorescent Reporters, Imaging, and Artificial Intelligence Toolkits to Monitor and Quantify Autophagy, Heterophagy, and Lysosomal Trafficking Fluxes

A review article published in Traffic by Maurizio Molinari’s laboratory describes state-of-the art tools and methods to monitor intracellular traffic of lysosomal enzymes, as well as the catabolic processes of autophagy and heterophagy. Bellinzona, November 07, 2024 – Lysosomal compartments control the clearance of cell-own material (autophagy) and of material that cells endocytose from the […]

Evidence for a new virus transmitted to humans by ticks in Mexico and Brazil

IRB PhD student Tomás Cervantes Rincón and colleagues in the United States, Mexico and Brazil discover evidence of a tick-borne Flavivirus transmitted to humans in tropical regions. The new study, published in Cell Reports, prompts future investigations to identify such virus and its relevance for human disease. Bellinzona, June 25, 2024 – Mosquitoes are known […]

IRB scientists receive SNSF research grants

Bellinzona, November 4, 2024 – Researchers at the Institute for Research in Biomedicine (IRB, affiliated with USI), were recently awarded important competitive research grants by the Swiss National Science Foundation (SNSF). Andrea Cavalli, head of the Laboratory of computational structural biology, was awarded for the Sinergia project “AntibodyGPT: Language Modeling for fast ex novo Monoclonal […]

A new study on the natural trapping mutant TMX5 and the proteostatic factor ERp44

A paper published in Life Science Alliance by the Molinari’s laboratory characterizes TMX5, a member of the protein disulfide isomerase (PDI) family, and reports on the involvement of ERp44, another member of the PDI family, in determining intracellular distribution and clients’ selection of TMX5. Bellinzona – October 17 2024 – The endoplasmic reticulum (ER) is […]

IRB awarded grant to improve laboratory animal welfare

Davide Manfredini, of the Institute for Research in Biomedicine (IRB) Comparative Biology team, was awarded the “Refinement Grant 2023” by the Swiss 3R Competence Centre (3RCC). A grant to further improve laboratory animal welfare. The term Refinement within the 3Rs (Replacement, Reduction, and Refinement) refers to methods aimed at reducing or alleviating pain, suffering, and […]

Mechanisms of influenza A virus entry

International PhD Program in Immunology, Cell Biology and Biochemistry 2024 / 2025 Prof. Dr. med. Yohei Yamauchi Institute of Pharmaceutical Sciences, ETH Zurich   Thursday, 14 November 2024 at 12 pm Bios+ Seminar Room Contact: Prof. Federica Sallusto