Publications - IRB USI

Publications

Allosteric Modulation of GCase Enhances Lysosomal Activity and Reduces ER Stress in GCase-Related Disorders
Fregno, I. Pérez-Carmona, N. Rudinskiy, M. Soldà, T. Bergmann, T. J. Ruano, A. Delgado, A. Cubero, E. Bellotto, M. García-Collazo, A. M. Molinari, M.
in Int. J. Mol. Sci. (2025) Vol.26 pp4392
ER-to-lysosome-associated degradation
Molinari, M.
in Curr Biol (2025) Vol.35 ppR320-R322
EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA
Roy, M. Sanchez, A. Guerois, R. Senoussi, I. Cerana, A. Sgrignani, J. Cavalli, A. Rinaldi, A. Cejka, P.
in Nat Commun (2025) Vol.16 pp4141
A Potent Nonapeptide Inhibitor for the CXCL12/HMGB1 heterocomplex: A Computational and Experimental Approach
Fassi, E., Pirani, E. Cecchinato, V. Cavalli, A. Roda, G. Uguccioni, M., Sgrignani, J., Grazioso, G.
in Comput. Struct. Biotechnol. J. (2025) Vol. pp
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
Jobin, K. Seetharama, D. Ruttger, L. Fenton, C. Kharybina, E. Wirsching, A. Huang, A. Knopper, K. Kaisho, T. Busch, D. H. Vaeth, M. Saliba, A. E. Graw, F. Pulfer, A. Gonzalez, S. F. Zehn, D. Liang, Y. Ugur, M. Gasteiger, G. Kastenmuller, W.
in Science (2025) Vol.388 ppeadq1405
The PIN1-p38-CtIP signalling axis protects stalled replication forks from deleterious degradation
Vivalda, F. Gatti, M. Manfredi, L. Dogan, H. Porro, A. Collotta, G. Ceppi, I. von Aesch, C. van Ackeren, V. Wild, S. Steger, M. Canovas, B. Cubillos-Rojas, M. Riera, A. Cejka, P. Nebreda, A. R. Dibitetto, D. Rottenberg, S. Sartori, A. A.
in Nucleic Acids Res (2025) Vol.53 pp
An in vivo microscopy dataset for the characterization of leukocyte death
Pulfer, A. Pizzagalli, D. U. Segura, M. P. Germic, N. Virgilio, T. Di Pilato, M. Carrillo Barbera, P. Palladino, E. Antonello, P. Thelen, M. Simon, H. U. Krause, R. Gonzalez, S. F.
in Sci Data (2025) Vol.12 pp593
Comprehensive interrogation of synthetic lethality in the DNA damage response
Fielden, J. Siegner, S. M. Gallagher, D. N. Schroder, M. S. Dello Stritto, M. R. Lam, S. Kobel, L. Schlapansky, M. F. Jackson, S. P. Cejka, P. Jost, M. Corn, J. E.
in Nature (2025) Vol.640 pp1093-1102
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
Lai, P. Liu, L. Bancaro, N. Troiani, M. Cali, B. Li, Y. Chen, J. Singh, P. K. Arzola, R. A. Attanasio, G. Pernigoni, N. Pasquini, E. Mosole, S. Rinaldi, A. Sgrignani, J. Qiu, S. Song, P. Desbats, M. A. Angel, A. R. Mestre, R. P. Cavalli, A. Barile, L. de Bono, J. Alimonti, A.
in Immunity (2025) Vol.58 pp811-825 e7
Mechanisms and regulation of DNA end resection in the maintenance of genome stability
Ceccaldi, R. Cejka, P.
in Nat Rev Mol Cell Biol (2025) Vol. pp
MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage
Seppa, I. M. Ceppi, I. Tennakoon, M. Reginato, G. Jackson, J. Rouault, C. D. Agashe, S. Sviderskiy, V. O. Limbu, M. Lantelme, E. Meroni, A. Braunshier, S. Borrello, D. Verma, P. Cejka, P. Vindigni, A.
in Genes Dev (2025) Vol.39 pp582-602.
New Synthesis and Pharmacological Evaluation of Enantiomerically Pure (R)- and (S)-Methadone Metabolites as N-Methyl-d-aspartate Receptor Antagonists
Banzato, M. Furlan, A. Locatelli, P. Sgrignani, J. Ongaro, A. Dolmella, A. De Martin, S. Comai, S. Cavalli, A. Inturrisi, C. Bettini, E. Manfredi, P. L. Mattarei, A.
in J Med Chem (2025) Vol.68 pp5455-5470
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
Szpakowska, M. Legler, D. F. Offermanns, S. Sozzani, S. Rot, A. Thelen, M. Chevigne, A.
in Nat Rev Immunol (2025) Vol. pp
Clonal analysis of SepSecS-specific B and T cells in autoimmune hepatitis
Kramer, M. Mele, F. Jovic, S. Fernandez, B. M. Jarrossay, D. Low, J. S. Sokollik, C. Filipowicz Sinnreich, M. Ferrari-Lacraz, S. Mieli-Vergani, G. Vergani, D. Lanzavecchia, A. Cassotta, A. Terziroli Beretta-Piccoli, B. Sallusto, F.
in J Clin Invest (2025) Vol.135 pp
Dual Activation-Induced Marker Combinations Efficiently Identify and Discern Antigen-Specific and Bystander-Activated Human CD4(+) T Cells
Ceraolo, M. G. Leccese, M. Cassotta, A. Triolo, S. Bombaci, M. Coluccio, E. Prati, D. Ungaro, R. Abrignani, S. Bandera, A. Sallusto, F. Lanzavecchia, A. Notarbartolo, S.
in Eur J Immunol (2024) Vol.55 ppe202451404
Ultrapotent IgA dimeric antibodies neutralize emerging Omicron variants
Zuo, F. Cao, Y. Sun, R. Wang, Q. Simonelli, L. Du, L. Bertoglio, F. Schubert, M. Guerra, C. Cavalli, A. Hust, M. Robbiani, D. F. Varani, L. Abolhassani, H. Xie, X. S. Hammarstrom, L. Marcotte, H. Pan-Hammarstrom, Q.
in J Virol (2024) Vol. ppe0174024
Discovery of a pan anti-SARS-CoV-2 monoclonal antibody with highly efficient infected cell killing capacity for novel immunotherapeutic approaches
Moussa, D. A. Vazquez, M. Chable-Bessia, C. Roux-Portalez, V. Tamagnini, E. Pedotti, M. Simonelli, L. Ngo, G. Souchard, M. Lyonnais, S. Chentouf, M. Gros, N. Marsile-Medun, S. Dinter, H. Pugniere, M. Martineau, P. Varani, L. Juan, M. Calderon, H. Naranjo-Gomez, M. Pelegrin, M.
in Emerg Microbes Infect (2024) Vol. pp2432345
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease
Tejedor Vaquero, S. Neuman, H. Comerma, L. Marcos-Fa, X. Corral-Vazquez, C. Uzzan, M. Pybus, M. Segura-Garzon, D. Guerra, Jo. Perruzza, L. Tacho-Pinot, R. Sintes, J. Rosenstein, A. Grasset, E. K. Iglesias, M. Gonzalez Farre, M. Lop, J. Patriaca-Amiano, M. E. Larrubia-Loring, M. Santiago-Diaz, P. Perera-Bel, J. Berenguer-Molins, P. Martinez Gallo, M. Martin-Nalda, A. Varela, E. Garrido-Pontnou, M. Grassi, F. Guarner, F. Mehandru, S. Marquez-Mosquera, L. Mehr, R. Cerutti, A. Magri, G.
in J Exp Med (2024) Vol.221 ppe20230079
Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis
Pietrasanta, C. Carlosama, C. Lizier, M. Fornasa, G. Jost, T. R. Carloni, S. Giugliano, S. Silvestri, A. Brescia, P. De Ponte Conti, B. Braga, D. Mihula, M. Morosi, L. Bernardinello, A. Ronchi, A. Martano, G. Mosca, F. Penna, G. Grassi, F. Pugni, L. Rescigno, M.
in Cell Host Microbe (2024) Vol.32 pp2178-2194.e6.
A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers
Spriano, F. Sartori, G. Sgrignani, J. Barnabei, L. Arribas, A. J. Guala, M. Del Amor, A. M. C. Tomasso, M. R. Tarantelli, C. Cascione, L. Golino, G. Riveiro, M. E. Bortolozzi, R. Lupia, A. Paduano, F. Huguet, S. Rezai, K. Rinaldi, A. Margheriti, F. Ventura, P. Guarda, G. Costa, G. Rocca, R. Furlan, A. Verdonk, L. M. Innocenti, P. Martin, N. I. Viola, G. Driessen, C. Zucca, E. Stathis, A. Gahtory, D. Van den Nieuwboer, M. Bornhauser, B. Alcaro, S. Trapasso, F. Cristobal, S. Padrick, S. B. Pazzi, N. Cavalli, F. Cavalli, A. Gaudio, E. Bertoni, F.
in Haematologica (2024) Vol.109 pp3602-3614
Fluorescent Reporters, Imaging, and Artificial Intelligence Toolkits to Monitor and Quantify Autophagy, Heterophagy, and Lysosomal Trafficking Fluxes
Rudinskiy, M. Morone, D. Molinari, M.
in Traffic (2024) Vol.25 ppe12957
SARS-CoV-2 mRNA vaccines do not worsen autoimmunity in patients with autoimmune liver diseases
Kalin, T. Passarin, K. Filipowic-Sinnreich, M. Semela, D. Seifert, T. Sallusto, F. Vergani, D. Cerny, A. Mieli-Vergani, G. Terziroli Beretta-Piccoli, B. Swiss Autoimmune Hepatitis Cohort, Study Swiss Primary Biliary Cholangitis Cohort, Study Swiss Primary Sclerosing Cholangitis, Study
in J Autoimmun (2024) Vol.149 pp103325
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the Nomenclature for Atypical Chemokine Receptors including ACKR5
Chevigne, A. Legler, D. F. Rot, A. Sozzani, S. Szpakowska, M. Thelen, M.
in Pharmacol Rev (2024) Vol.77 pp100012
PI3Kdelta activation, IL6 overexpression, and CD37 loss cause resistance to naratuximab emtansine in lymphomas
Arribas, A. J. Napoli, S. Gaudio, E. Herbaux, C. Cannas, E. Tarantelli, C. Bordone Pittau, R. Cascione, L. Munz, N. Aresu, L. Sgrignani, J. Rinaldi, A. Kwee, I. Rossi, D. Cavalli, A. Zucca, E. Stussi, G. Stathis, A. Sloss, C. Davids, M. S. Bertoni, F.
in Blood Adv (2024) Vol.8 pp6268-6281
Postnatal supplementation with alarmins S100a8/a9 ameliorates malnutrition-induced neonate enteropathy in mice
Perruzza, L. Heckmann, J. Rezzonico Jost, T. Raneri, M. Guglielmetti, S. Gargari, G. Palatella, M. Willers, M. Fehlhaber, B. Werlein, C. Vogl, T. Roth, J. Grassi, F. Viemann, D.
in Nat Commun (2024) Vol.15 pp8623

Istituto di Ricerca in Biomedicina

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