To target, to escape – perchance to cure. Gene engineering of surface epitopes to empower cancer immunotherapy and beyond
IRB Special Seminar Dr. Gabriele Casirati Department of Hematology/Oncology Dana-Farber/Boston Children’s Cancer and Blood Disorder Center, Boston Wednesday, 28 August 2024 at 2.15 pm Bios+ Seminar Room
Immunity and Metabolism go viral
IRB Special Seminar Dr. Samuel Nobs Department of Systems Immunology, Weizmann Institute of Science Wednesday, 28 August 2024 at 1.30 pm Bios+ Seminar Room
HLTF removes Cas9 from DNA breaks
A paper published in the journal “Nature Communications” by the Cejka laboratory shows that the HLTF, a protein known to remodel replication forks, can unexpectedly dislocate Cas9 from the DNA after cleavage to initiate DNA double-stranded break repair. Bellinzona – July 10 2024 – During gene editing, the repair of DNA double-stranded breaks generated with […]
Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition
A new study published by the Grassi laboratory and collaborators in “Cell Reports Medicine” demonstrates that releasing the inhibitory effect of adenosine-triphosphate (ATP) on secretory IgA production in the gut protects from enteropathy and restores growth in malnourished newborns Bellinzona – July 5 2024 – Living in impoverished environments is the cause of stunting for […]
Structural mechanism of the ubiquitin ligase HACE1
IRB Special Seminar Dr. Sonja Lorenz Max – Planck-Institut, Göttingen (GER) Tuesday, 30 July 2024 at 11 am Bios+ Seminar Room Contact: Dr. Andrea Cavalli
Using community-based cohort studies in Brazil to gain insights on immunity to emerging infections
Prof. Albert Ko Yale School of Public Health Monday, 22 July2024 at 04 pm Bios+Seminar Room Contact: Prof. Davide Robbiani This event is supported by the IRB-Rockefeller University partnership for infectious disease research.
From drug design to protein design
IRB Special Seminar Dr. Raffaele Passannanti Faculty of Sciences of the Scuola Normale Superiore (IT) Thursday, 4 July 2024 at 12 pm Bios+ Seminar Room Contact: Dr. Andrea Cavalli
A new study characterizes the role of the heterocomplex CXCL12/HMGB1 in cancer cells
Bellinzona – June 14 2024 – Despite the established roles of both HMGB1 and CXCL12 in tumour progression and metastatic spread to distal sites, the role of the CXCL12/HMGB1 heterocomplex in cancer has never been investigated. In the study, published in Frontiers in Immunology by Pirani et al., a new mass spectrometry protocol was established […]
Mechanism of Mre11 Activation by Sae2/CtIP Unveiled: Insights from AlphaFold2, Biochemical, and Genetic Assays
Bellinzona – June 13 2024 – A new study published by the Cejka laboratory and collaborators in “Molecular Cell” provides molecular insight into the activation of Mre11-Rad50- endonuclease activity by Sae2/CtIP. In Saccharomyces cerevisiae (S. cerevisiae), Mre11-Rad50-Xrs2 (MRX)-Sae2 nuclease activity is required for the resection of DNA breaks with secondary structures or protein blocks, while in […]
New SNSF grants awarded to four IRB researchers
Bellinzona – June 11 2024 – The Swiss National Science Foundation (SNSF) has recently awarded SNSF grants to four researchers at the Institute for Research in Biomedicine (IRB, affiliated to Università della Svizzera italiana): Valentina Cecchinato, Greta Guarda, Maurizio Molinari, and Silvia Monticelli. Valentina Cecchinato, research associate hosted in the group of Mariagrazia Uguccioni, focuses […]
