Publications Archive

ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production
Antonello, P. Pizzagalli, D. U. Foglierini, M. Melgrati, S. Radice, E. Thelen, S. Thelen, M.
in Front Immunol (2023) Vol.13 pp1067885
Comparative Assessment of the Binding and Neutralisation Activity of Bispecific Antibodies Against SARS-CoV-2 Variants
Dean, A. Q. Stauft, C. B. Twomey, J. D. Tan, J. Varani, L. Wang, T. T. Zhang, B.
in Antib Ther (2022) Vol.6 pp49-58
A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity
Roehlen, N. Saviano, A. El Saghire, H. Crouchet, E. Nehme, Z. Del Zompo, F. Juhling, F. Oudot, M. A. Durand, S. C. Duong, F. H. T. Cherradi, S. Gonzalez Motos, V. Almeida, N. Ponsolles, C. Heydmann, L. Ostyn, T. Lallement, A. Pessaux, P. Felli, E. Cavalli, A. Sgrignani, J. Thumann, C. Koutsopoulos, O. Fuchs, B. C. Hoshida, Y. Hofmann, M. Vyberg, M. Viuff, B. M. Galsgaard, E. D. Elson, G. Toso, A. Meyer, M. Iacone, R. Schweighoffer, T. Teixeira, G. Moll, S. De Vito, C. Roskams, T. Davidson, I. Heide, D. Heikenwalder, M. Zeisel, M. B. Lupberger, J. Mailly, L. Schuster, C. Baumert, T. F.
in Sci Transl Med (2022) Vol.14 ppeabj4221
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures
Mengoli, V. Ceppi, I. Sanchez, A. Cannavo, E. Halder, S. Scaglione, S. Gaillard, P. H. McHugh, P. J. Riesen, N. Pettazzoni, P. Cejka, P.
in EMBO J (2022) Vol. ppe111998
Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress
Hung, H. H. Nagatsuka, Y. Solda, T. Kodali, V. K. Iwabuchi, K. Kamiguchi, H. Kano, K. Matsuo, I. Ikeda, K. Kaufman, R. J. Molinari, M. Greimel, P. Hirabayashi, Y.
in Proc Natl Acad Sci U S A (2022) Vol.119 ppe2214957119
Clonal composition and persistence of antigen-specific circulating T follicular helper cells
Hu, M. Notarbartolo, S. Foglierini, M. Jovic, S. Mele, F. Jarrossay, D. Lanzavecchia, A. Cassotta, A. Sallusto, F.
in Eur J Immunol (2022) Vol.53 ppe2250190.
Longitudinal Postvaccine SARS-CoV-2 Immunoglobulin G Titers, Memory B-Cell Responses, and Risk of COVID-19 in Multiple Sclerosis Over 1 Year
Disanto, G. Galante, A. Cantu, M. Sacco, R. Mele, F. Eisler, J. J. Keller, F. Bernasconi, E. Sallusto, F. Zecca, C. Gobbi, C.
in Neurol Neuroimmunol Neuroinflamm (2022) Vol.10 pp:e200043.
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines
Bowen, J. E. Park, Y. J. Stewart, C. Brown, J. T. Sharkey, W. K. Walls, A. C. Joshi, A. Sprouse, K. R. McCallum, M. Tortorici, M. A. Franko, N. M. Logue, J. K. Mazzitelli, I. G. Nguyen, A. W. Silva, R. P. Huang, Y. Low, J. S. Jerak, J. Tiles, S. W. Ahmed, K. Shariq, A. Dan, J. M. Zhang, Z. Weiskopf, D. Sette, A. Snell, G. Posavad, C. M. Iqbal, N. T. Geffner, J. Bandera, A. Gori, A. Sallusto, F. Maynard, J. A. Crotty, S. Van Voorhis, W. C. Simmerling, C. Grifantini, R. Chu, H. Y. Corti, D. Veesler, D.
in Sci Immunol (2022) Vol. ppeadf1421
Heterogeneity of tissue-resident immunity across organs and in health and disease
Arck, P. C. Sallusto, F.
in Semin Immunopathol (2022) Vol.44 pp745-746.
Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1alpha-STAT3 axis
Virgilio, T. Bordini, J. Cascione, L. Sartori, G. Latino, I. Molina Romero, D. Leoni, C. Akhmedov, M. Rinaldi, A. Arribas, A. J. Morone, D. Seyed Jafari, S. M. Bersudsky, M. Ottolenghi, A. Kwee, I. Chiaravalli, A. M. Sessa, F. Hunger, R. E. Bruno, A. Mortara, L. Voronov, E. Monticelli, S. Apte, R. N. Bertoni, F. Gonzalez, S. F.
in Cancer Immunol Res (2022) Vol.10 pp1525-1541
Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses
Ventura, P. M. O. Gakovic, M. Fischer, B. A. Spinelli, L. Rota, G. Pathak, S. Khameneh, H. J. Zenobi, A. Thomson, S. Birchmeier, W. Cantrell, D. A. Guarda, G.
in EMBO Rep (2022) Vol. ppe55399
Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
Marzi, R. Bassi, J. Silacci-Fregni, C. Bartha, I. Muoio, F. Culap, K. Sprugasci, N. Lombardo, G. Saliba, C. Cameroni, E. Cassotta, A. Low, J. S. Walls, A. C. McCallum, M. Tortorici, M. A. Bowen, J. E. Dellota, E. A. Dillen, J. R. Czudnochowski, N. Pertusini, L. Terrot, T. Lepori, V. Tarkowski, M. Riva, A. Biggiogero, M. Pellanda, A. F. Garzoni, C. Ferrari, P. Ceschi, A. Giannini, O. Havenar-Daughton, C. Telenti, A. Arvin, A. Virgin, H. W. Sallusto, F. Veesler, D. Lanzavecchia, A. Corti, D. Piccoli, L.
in iScience (2022) Vol.26 pp105726
Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2
Halder, S. Sanchez, A. Ranjha, L. Reginato, G. Ceppi, I. Acharya, A. Anand, R. Cejka, P.
in Mol Cell (2022) Vol. pp
Different classes of genomic inserts contribute to human antibody diversity
Lebedin, M. Foglierini, M. Khorkova, S. Vazquez Garcia, C. Ratswohl, C. Davydov, A. N. Turchaninova, M. A. Daubenberger, C. Chudakov, D. M. Lanzavecchia, A. de la Rosa, K.
in Proc Natl Acad Sci U S A (2022) Vol.119 ppe2205470119
CEMIP (HYBID, KIAA1199): Structure, function and expression in health and disease
Spataro, S. Guerra, C. Cavalli, A. Sgrignani, J. Sleeman, J. Poulain, L. Boland, A. Scapozza, L. Moll, S. Prunotto, M.
in FEBS J (2022) Vol.290 pp3946-3962
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes
Clement, C. C. Osan, J. Buque, A. Nanaware, P. P. Chang, Y. C. Perino, G. Shetty, M. Yamazaki, T. Tsai, W. L. Urbanska, A. M. Calvo-Calle, J. M. Ramsamooj, S. Vergani, D. Mieli-Vergani, G. Terziroli Beretta-Piccoli, B. Gadina, M. Montagna, C. Goncalves, M. D. Sallusto, F. Galluzzi, L. Soni, R. K. Stern, L. J. Santambrogio, L.
in Sci Immunol (2022) Vol.7 ppeabl3795
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors
Bettini, E. Stahl, S. M. De Martin, S. Mattarei, A. Sgrignani, J. Carignani, C. Nola, S. Locatelli, P. Pappagallo, M. Inturrisi, C. E. Bifari, F. Cavalli, A. Alimonti, A. Pani, L. Fava, M. Traversa, S. Folli, F. Manfredi, P. L.
in Pharmaceuticals (Basel) (2022) Vol.15 pp
Discovery of anti-Formin-like 1 protein (FMNL1) antibodies in membranous nephropathy and other glomerular diseases
Bruschi, M. Cavalli, A. Moll, S. Candiano, G. Scapozza, L. Patel, J. J. Tan, J. C. Lo, K. C. Angeletti, A. Ghiggeri, G. M. Prunotto, M.
in Sci Rep (2022) Vol.12 pp13659
A conformational switch controlling the toxicity of the prion protein
Frontzek, K. Bardelli, M. Senatore, A. Henzi, A. Reimann, R. R. Bedir, S. Marino, M. Hussain, R. Jurt, S. Meisl, G. Pedotti, M. Mazzola, F. Siligardi, G. Zerbe, O. Losa, M. Knowles, T. Lakkaraju, A. Zhu, C. Schwarz, P. Hornemann, S. Holt, M. G. Simonelli, L. Varani, L. Aguzzi, A.
in Nat Struct Mol Biol (2022) Vol.29 pp831-840
* Marco Bardelli and Karl Frontzek contributed equally to this work (co-first), Luca Varani is corresponding authors.
The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
Ito-Kureha, T. Leoni, C. Borland, K. Cantini, G. Bataclan, M. Metzger, R. N. Ammann, G. Krug, A. B. Marsico, A. Kaiser, S. Canzar, S. Feske, S. Monticelli, S. Konig, J. Heissmeyer, V.
in Nat Immunol (2022) Vol. pp
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
Low, J. S. Jerak, J. Tortorici, M. A. McCallum, M. Pinto, D. Cassotta, A. Foglierini, M. Mele, F. Abdelnabi, R. Weynand, B. Noack, J. Montiel-Ruiz, M. Bianchi, S. Benigni, F. Sprugasci, N. Joshi, A. Bowen, J. E. Stewart, C. Rexhepaj, M. Walls, A. C. Jarrossay, D. Morone, D. Paparoditis, P. Garzoni, C. Ferrari, P. Ceschi, A. Neyts, J. Purcell, L. A. Snell, G. Corti, D. Lanzavecchia, A. Veesler, D. Sallusto, F.
in Science (2022) Vol. ppeabq2679
Strand annealing and motor driven activities of SMARCAL1 and ZRANB3 are stimulated by RAD51 and the paralog complex
Halder, S. Ranjha, L. Taglialatela, A. Ciccia, A. Cejka, P.
in Nucleic Acids Res (2022) Vol. pp
Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts
Phad, G. E. Pinto, D. Foglierini, M. Akhmedov, M. Rossi, R. L. Malvicini, E. Cassotta, A. Fregni, C. S. Bruno, L. Sallusto, F. Lanzavecchia, A.
in Nat Immunol (2022) Vol. pp
Effects of Antibody Responses to Pre-Existing Coronaviruses on Disease Severity and Complement Activation in COVID-19 Patients
Cugno, M. Meroni, P. L. Consonni, D. Griffini, S. Grovetti, E. Novembrino, C. Torri, A. Griffante, G. Gariglio, M. Varani, L. Peyvandi, F.
in Microorganisms (2022) Vol.10 pp
* Luca Varani is co-corresponding author
Reply to: Hultstrom et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19
Asselta, R. Paraboschi, E. M. Stravalaci, M. Invernizzi, P. Bonfanti, P. Biondi, A. Pagani, I. Pedotti, M. Doni, A. Scavello, F. Mapelli, S. N. Sironi, M. Perucchini, C. Varani, L. Matkovic, M. Cavalli, A. Cesana, D. Gallina, P. Pedemonte, N. Capurro, V. Clementi, N. Mancini, N. Bayarri-Olmos, R. Garred, P. Rappuoli, R. Duga, S. Bottazzi, B. Uguccioni, M. Vicenzi, E. Mantovani, A. Garlanda, C.
in Nat Immunol (2022) Vol.23 pp865-867
Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients
Garcia-Cuesta, E. M. Rodriguez-Frade, J. M. Gardeta, S. R. D'Agostino, G. Martinez, P. Soler Palacios, B. Cascio, G. Wolf, T. Mateos, N. Ayala-Bueno, R. Santiago, C. A. Lucas, P. Llorente, L. Allende, L. M. Gonzalez-Granado, L. I. Martin-Cofreces, N. Roda-Navarro, P. Sallusto, F. Sanchez-Madrid, F. Garcia-Parajo, M. F. Martinez-Munoz, L. Mellado, M.
in Proc Natl Acad Sci U S A (2022) Vol.119 ppe2119483119
Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant
Zuo, F. Abolhassani, H. Du, L. Piralla, A. Bertoglio, F. de Campos-Mata, L. Wan, H. Schubert, M. Cassaniti, I. Wang, Y. Sammartino, J. C. Sun, R. Vlachiotis, S. Bergami, F. Kumagai-Braesch, M. Andrell, J. Zhang, Z. Xue, Y. Wenzel, E. V. Calzolai, L. Varani, L. Rezaei, N. Chavoshzadeh, Z. Baldanti, F. Hust, M. Hammarstrom, L. Marcotte, H. Pan-Hammarstrom, Q.
in Nat Commun (2022) Vol.13 pp2670
Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity
Fassi, E. M. A. Garofalo, M. Sgrignani, J. Dei Cas, M. Mori, M. Roda, G. Cavalli, A. Grazioso, G.
in Int J Mol Sci (2022) Vol.23 pp
Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation
Latorre, D. Sallusto, F. Bassetti, C. L. A. Kallweit, U.
in Semin Immunopathol (2022) Vol.44 pp611-623
19n01, a Broadly Neutralizing Antibody Against Omicron BA. 1, BA. 2, BA. 4/5, and Other SARS-CoV-2 Variants of Concern
García-Vega, M., Melgoza-González, E.A., Hernández-Valenzuela, S., Hinojosa-Trujillo, D., Reséndiz-Sandoval, M., Llamas-Covarrubias, M.A., Loza-Lopez, M., Valenzuela, O., Soto-Gaxiola, A., Hernández-Oñate, M. A., Mata-Haro, V., Cassaniti, I., Sammartino, J.C., Ferrari, A., Simonelli, L., Pedotti, M., Sun, R. , Zuo, F., Baldanti, F., Varani, L., Marcotte, H., Pan-Hammarström, Q., Hernández, J.
in iScience (2022) Vol.26 pp106562.
Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis
Perruzza, L. Strati, F. Raneri, M. Li, H. Gargari, G. Rezzonico-Jost, T. Palatella, M. Kwee, I. Morone, D. Seehusen, F. Sonego, P. Donati, C. Franceschi, P. Macpherson, A. J. Guglielmetti, S. Greiff, V. Grassi, F.
in Cell Rep (2022) Vol.40 pp111112
Emerging roles for RNA-binding proteins in T lymphocytes
Monticelli, S.
in Immunol Lett (2022) Vol.246 pp52-56
Mre11-Rad50 oligomerization promotes DNA double-strand break repair
Kissling, V. M. Reginato, G. Bianco, E. Kasaciunaite, K. Tilma, J. Cereghetti, G. Schindler, N. Lee, S. S. Guerois, R. Luke, B. Seidel, R. Cejka, P. Peter, M.
in Nat Commun (2022) Vol.13 pp2374
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology
Sherina, N. de Vries, C. Kharlamova, N. Sippl, N. Jiang, X. Brynedal, B. Kindstedt, E. Hansson, M. Mathsson-Alm, L. Israelsson, L. Stålesen, R. Saevarsdottir, S. Holmdahl, R. Hensvold, A. Johannsen, G. Eriksson, K. Sallusto, F. Catrina, A. I. Rönnelid, J. Grönwall, C. Yucel-Lindberg, T. Alfredsson, L. Klareskog, L. Piccoli, L. Malmström, V. Amara, K. Lundberg, K.
in Frontiers in Immunology (2022) Vol.13 pp
Development of spirulina for the manufacture and oral delivery of protein therapeutics
Jester, B. W. Zhao, H. Gewe, M. Adame, T. Perruzza, L. Bolick, D. T. Agosti, J. Khuong, N. Kuestner, R. Gamble, C. Cruickshank, K. Ferrara, J. Lim, R. Paddock, T. Brady, C. Ertel, S. Zhang, M. Pollock, A. Lee, J. Xiong, J. Tasch, M. Saveria, T. Doughty, D. Marshall, J. Carrieri, D. Goetsch, L. Dang, J. Sanjaya, N. Fletcher, D. Martinez, A. Kaldis, B. Sigmar, K. Afreen, E. Nguyen, T. Randolph, A. Taber, A. Krzeszowski, A. Robinett, B. Volkin, D. B. Grassi, F. Guerrant, R. Takeuchi, R. Finrow, B. Behnke, C. Roberts, J.
in Nat Biotechnol (2022) Vol.40 pp956-964
The immunology and immunopathology of COVID-19
Merad, M. Blish, C. A. Sallusto, F. Iwasaki, A.
in Science (2022) Vol.375 pp1122-1127
ER-phagy: mechanisms, regulation and diseases connected to the lysosomal clearance of the endoplasmic reticulum
Reggiori, F. Molinari, M.
in Physiol Rev (2022) Vol. pp
CANCOL, a Computer-Assisted Annotation Tool to Facilitate Colocalization and Tracking of Immune Cells in Intravital Microscopy
Pizzagalli, D. U. Bordini, J. Morone, D. Pulfer, A. Carrillo-Barbera, P. Thelen, B. Ceni, K. Thelen, M. Krause, R. Gonzalez, S. F.
in J Immunol (2022) Vol. pp
GPCR Inhibition in Treating Lymphoma
Barreca, M. Spano, V. Raimondi, M. V. Bivacqua, R. Giuffrida, S. Montalbano, A. Cavalli, A. Bertoni, F. Barraja, P.
in Acs Medicinal Chemistry Letters (2022) Vol.13 pp358-364
RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells
Chirichella, M. Bianchi, N. Dzafo, E. Foli, E. Gualdrini, F. Kenyon, A. Natoli, G. Monticelli, S.
in PLoS Biol (2022) Vol.20 ppe3001538
The CDK1-TOPBP1-PLK1 axis regulates the Bloom’s syndrome helicase BLM to suppress crossover recombination in somatic cells
Balbo Pogliano, C. Ceppi, I. Giovannini, S. Petroulaki, V. Palmer, N. Uliana, F. Gatti, M. Kasaciunaite, K. Freire, R. Seidel, R. Altmeyer, M. Cejka, P. Matos, J.
in Sci Adv (2022) Vol.8 ppeabk0221
Quantitative and Time-Resolved Monitoring of Organelle and Protein Delivery to the Lysosome with A Tandem Fluorescent Halo-GFP reporter
Rudinskiy, M. Bergmann, T. J. Molinari, M.
in Mol Biol Cell (2022) Vol. ppmbcE21100526
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules
Stravalaci, M. Pagani, I. Paraboschi, E. M. Pedotti, M. Doni, A. Scavello, F. Mapelli, S. N. Sironi, M. Perucchini, C. Varani, L. Matkovic, M. Cavalli, A. Cesana, D. Gallina, P. Pedemonte, N. Capurro, V. Clementi, N. Mancini, N. Invernizzi, P. Bayarri-Olmos, R. Garred, P. Rappuoli, R. Duga, S. Bottazzi, B. Uguccioni, M. Asselta, R. Vicenzi, E. Mantovani, A. Garlanda, C.
in Nat Immunol (2022) Vol.23 pp275-286
Immunity to SARS-CoV-2 up to 15 months after infection
Marcotte, H. Piralla, A. Zuo, F. Du, L. Cassaniti, I. Wan, H. Kumagai-Braesh, M. Andrell, J. Percivalle, E. Sammartino, J. C. Wang, Y. Vlachiotis, S. Attevall, J. Bergami, F. Ferrari, A. Colaneri, M. Vecchia, M. Sambo, M. Zuccaro, V. Asperges, E. Bruno, R. Oggionni, T. Meloni, F. Abolhassani, H. Bertoglio, F. Schubert, M. Calzolai, L. Varani, L. Hust, M. Xue, Y. Hammarstrom, L. Baldanti, F. Pan-Hammarstrom, Q.
in iScience (2022) Vol.25 pp103743
Behavioural immune landscapes of inflammation
Crainiciuc, G. Palomino-Segura, M. Molina-Moreno, M. Sicilia, J. Aragones, D. G. Li, J. L. Y. Madurga, R. Adrover, J. M. Aroca-Crevillen, A. Martin-Salamanca, S. Del Valle, A. S. Castillo, S. D. Welch, H. C. E. Soehnlein, O. Graupera, M. Sanchez-Cabo, F. Zarbock, A. Smithgall, T. E. Di Pilato, M. Mempel, T. R. Tharaux, P. L. Gonzalez, S. F. Ayuso-Sacido, A. Ng, L. G. Calvo, G. F. Gonzalez-Diaz, I. Diaz-de-Maria, F. Hidalgo, A.
in Nature (2022) Vol. pp

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