Publications Archive

Human IFN-gamma immunity to mycobacteria is governed by both IL-12 and IL-23
Martinez-Barricarte, R. Markle, J. G. Ma, C. S. Ramirez-Alejo, N. Mele, F. Latorre, D. Mahdaviani, S. A. Aytekin, C. Mansouri, D. Bryant, V. L. Jabot-Hanin, F. Deswarte, C. Nieto-Patlan, A. Surace, L. Kerner, G. Itan, Y. Jovic, S. Avery, D. T. Wong, N. Rao, G. Patin, E. Okada, S. Bigio, B. Boisson, B. Rapaport, F. Seeleuthner, Y. Schmidt, M. Ikinciogullari, A. Dogu, F.
in Sci Immunol (2018) Vol.3 ppii: eaau6759
A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow
Mossu, A. Rosito, M. Khire, T. Nishihara, H. Gruber, I. Luke, E. Dehouck, L. Sallusto, F. Gosselet, F. McGrath, J. L. Engelhardt, B.
in J Cereb Blood Flow Metab (2018) Vol. pp271678X18820584
BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
D'Alessandro, G. Whelan, D. R. Howard, S. M. Renaudin, X. Adamowicz, M. Iannelli, F. Jones-Weinert, C. W. Lee, M. Matti, V. Lee, W. T. C. Morten, M. J. Venkitaraman, A. R. Cejka, P. Rothenberg, E. d'Adda di Fagagna, F.
in Nat Commun (2018) Vol.9 pp5376
The danger signal extracellular ATP is involved in the immuno-mediated damage of alpha-sarcoglycan deficient muscular dystrophy
Gazzerro, E. Baratto, S. Assereto, S. Panicucci, C. Raffaghello, L. Scudieri, P. De Battista, D. Fiorillo, C. Volpi, S. Chaabane, L. Malnati, M. Messina, G. Bruzzone, S. Traggiai, E. Grassi, F. Minetti, C. Bruno, C.
in Am J Pathol (2018) Vol. pp31150-1.
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis
Girbl, T. Lenn, T. Perez*, L. Barkaway, A. Thiriot, A. Del Fresno, C. Lynam, E. Hub, E. Thelen, M. Graham, G. Alon, R. Sancho, D. von Andrian, U. H. Voisin, M. B. Rot, A. Nourshargh, S.
in Immunity (2018) Vol.49 pp1062-1076.
Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4
Stewart-Jones, G. B. E. Chuang, G. Y. Xu, K. Acharya, P. Tsybovsky, Y. Ou, L. Zhang, B. Fernandez-Rodriguez, B. Gilardi, V. Silacci-Fregni, C. Beltramello, M. Baxa, U. Druz, A. Kong, W. P. Thomas, P. V. Yang, Y. Foulds, K. E. Todd, J. P. Wei, H. Salazar, A. M. Scorpio, D. G. Carragher, B. Potter, C. S. Corti, D. Mascola, J. R. Lanzavecchia, A. Kwong, P. D.
in Proc Natl Acad Sci U S A (2018) Vol.115 pp12265-12270.
Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis
Cecchinato, V. D'Agostino, G. Raeli, L. Schiraldi, M. Danelon, G. Manzo, A. Thelen, M. Ciurea, A. Bianchi, M. E. Rubartelli, A. Pitzalis, C. Uguccioni, M.
in Front Immunol (2018) Vol.9 pp2118
How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study
Sgrignani, J. Chen, J. Alimonti, A. Cavalli, A.
in Sci Rep (2018) Vol.8 pp14683
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
Bardelli, M. Frontzek, K. Simonelli, L. Pedotti, M. Mazzola, F. Carta, M. Eckhardt, V. D'Antuono, R. Virgilio, T. Gonzalez, S. F. Aguzzi, A. Varani, L.
in PLoS Pathog (2018) Vol.14 ppe1007335
Regulatory control of DNA end resection by Sae2 phosphorylation
Cannavo, E. Johnson, D. Andres, S. N. Reinert, J. K. Garcia, V. Erie, D. A. Hess, D. Thoma, N. H. Enchev, R. I. Peter, M. Williams, R. S. Neale, M. J. Cejka, P.
in Nat Commun (2018) Vol.9 pp4016
Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity
D'Agostino, G. Cecchinato, V. Uguccioni, M.
in Front Immunol (2018) Vol.9 pp2185
T cells in patients with narcolepsy target self-antigens of hypocretin neurons
Latorre, D. Kallweit, U. Armentani, E. Mele, F. Cassotta, A. Jovic, S. Jarrossay, D. Mathis, J. Zellini, F. Becher, B. Lanzavecchia, A. Khatami, R. Manconi, M. Tafti, M. Bassetti, C. L. Sallusto, F.
in Nature (2018) Vol.562 pp63-68
Influenza hemagglutinin membrane anchor
Benton, D. J. Nans, A. Calder, L. J. Neu, U. Lin, Y. P. Ketelaars, E. Kallewaard, N. L. Corti, D. Lanzavecchia, A. Gamblin, S. J. Rosenthal, P. B. Skehel, J. J.
in Proc Natl Acad Sci U S A (2018) Vol.115 pp10112-10117
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
Aschenbrenner, D. Foglierini, M. Jarrossay, D. Weiner, H. L. Kuchroo, V. K. Lanzavecchia, A. Notarbartolo, S. Sallusto, F.
in Nat Immunol (2018) Vol.19 pp1126-1136
MicroRNAs as modulators of T cell functions in cancer
Emming, S. Chirichella, M. Monticelli, S.
in Cancer Letters (2018) Vol.430 pp172-178
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
Kong, X. F. Martinez-Barricarte, R. Kennedy, J. Lazarov, T. Deenick, E. K. Ma, C. S. Breton, G. Lucero, K. B. Langlais, D. Bousfiha, A. Aytekin, C. Markle, J. Trouillet, C. Jabot-Hanin, F. Arlehamn, C. S. L. Rao, G. Picard, C. Lasseau, T. Latorre, D. Hambleton, S. Deswarte, C. Itan, Y. Abarca, K. Moraes-Vasconcelos, D. Ailal, F. Ikinciogullari, A. Dogu, F. Benhsaien, I. Sette, A.
in Nat Immunol (2018) Vol.19 pp973-985
Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy
Palomino-Segura, M. Virgilio, T. Morone, D. Gonzalez, S.
in JoVE (2018) Vol. ppe58355
Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration
D'Agostino, G. Saporito, A. Cecchinato, V. Borgeat, A. Anselmi, L. Uguccioni, M.
in British Journal of Anaesthesia (2018) Vol.121 pp962-968
Regulation of the beta-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis
Ghiasi, S. M. Dahllof, M. S. Osmai, Y. Jakobsen, K. K. Aivazidis, A. Tyrberg, B. Perruzza, L. Prause, M. C. B. Christensen, D. P. Fog-Tonnesen, M. Lundh, M. Grassi, F. Chatenoud, L. Mandrup-Poulsen, T.
in Mol Cell Endocrinol (2018) Vol.478 pp106-114
ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport
Fregno, I. Fasana, E. Bergmann, T. J. Loi, M. Solda, T. Galli, C. D'Antuono, R. Morone, D. Danieli, A. Paganetti, P. van Anken, E. Molinari, M.
in EMBO J (2018) Vol.37 ppe99259
An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor
Martinez-Martin, N. Marcandalli, J. Huang, C. S. Perotti, M. Foglierini, M. Ho, H. Dosey, A. M. Shriver, S. Payandeh, J. Leitner, A. Lanzavecchia, A. Perez, L. Ciferri, C.
in Cell (2018) Vol.174 pp1158-1171
* L. Perez and C. Ciferri contributed equally; N M-M, LP and CC are co-corresponding authors
Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts
Kassem, M. M. Christoffersen, L. B. Cavalli, A.
in Sci Rep (2018) Vol.8 pp11112
Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos
Pizzagalli, D. U. Farsakoglu, Y. Palomino-Segura, M. Sintes, J. Marangoni, F. Mempel, T. R. Koh, W. H. Murooka, T. T. Thelen, F. Stein, J. V. Pozzi, G. Thelen, M. Krause, R. Gonzalez, S. F.
in Sci Data (2018) Vol.5 pp180129
Three branches to rule them all? UPR signaling in response to chemically- versus misfolded proteins-induced ER stress
Bergmann, T. J. Molinari, M.
in Biol Cell (2018) Vol.110 pp197-204
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
Castro, W. Chelbi, S. T. Niogret, C. Welten, S. P. M. Osterheld, K. Wang, H. Rota, G. Morgado, L. Vivier, E. Raeber, M. E. Boyman, O. Delorenzi, M. Barras, D. Ho, P. C. Oxenius, A. Guarda, G.
in Nat Immunol (2018) Vol.19 pp809-820
The reductase TMX1 contributes to ERAD by preferentially acting on membrane-associated folding-defective polypeptides
Guerra, C. Brambilla Pisoni, G. Solda, T. Molinari, M.
in Biochem Biophys Res Commun (2018) Vol. pp938 - 943
Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis
Armas-Gonzalez, E. Dominguez-Luis, M. J. Diaz-Martin, A. Castro-Hernandez, J. Danelon, G. Hernandez-Hernandez, V. Bustabad-Reyes, S. Cantabrana, A. Uguccioni, M. Diaz-Gonzalez, F.
in Arthritis Res Ther (2018) Vol.20 pp114
Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development
Sgrignani, J Garofalo, M Matkovic, M Catapano, C. V. Cavalli, A.
in Int. J. Mol. Sci. (2018) Vol.19 pp1591
Eat it right: ER-phagy and recovER-phagy
Loi, M. Fregno, I. Guerra, C., Molinari, M.
in Biochem Soc Trans (2018) Vol. pp699–706
Human cytomegalovirus (HCMV)-specific T-cell but not neutralizing or ELISA IgG antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients
Lilleri, D. Zelini, P. Fornara, C. Rampino, T. Perez, L. Gabanti, E. Gerna, G.
in J Med Virol (2018) Vol.90 pp1620-1628
Mapping Antibody Epitopes by Solution NMR Spectroscopy: Practical Considerations
Simonelli, L. Pedotti, M. Bardelli, M. Zerbe, O. Varani, L.
in Methods Mol Biol (2018) Vol.1785 pp29-51
Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone
Pickett, J. E. Thompson, J. M. Sadowska, A. Sellman, B. R. Minola, A. Corti, D. Lanzavecchia, A. Miller, L. S. Thorek, D. L.
in Bone Res (2018) Vol.6 pp13
False human cytomegalovirus IgG-positivity at prenatal screening
Furione, M. Sarasini, A. Arossa, A. Lilleri, D. Perez, L. Parea, M. Zavattoni, M. Spinillo, A. Marone, P. Baldanti, F.
in J Clin Virol (2018) Vol.104 pp34-38
Insight on the regulation of chemokine activities
Cecchinato, V. Uguccioni, M.
in J Leukoc Biol (2018) Vol.104 pp295-300
Endoplasmic reticulum turnover: ER-phagy and other flavors in selective and non-selective ER clearance
Fregno, I. Molinari, M.
in F1000Res (2018) Vol.7 pp454
Modulation of innate and adaptive immunity by P2X ion channels
Di Virgilio, F. Sarti, A. C. Grassi, F.
in Curr Opin Immunol (2018) Vol.52 pp51-59
Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
Rota, G. Niogret, C. Dang, A. T. Fonta, N. P. Alfei, F. Morgado, L. Zehn, D. Birchmeier, W. Vivier, E. Guarda, G.
in Cell Rep (2018) Vol.23 pp39-49
Characterization of a chimeric chemokine as a specific ligand for ACKR3
Ameti, R. Melgrati, S. Radice, E. Hub, E. Thelen, S. Rot, A. Thelen, M.
in J Leukoc Biol (2018) Vol.104 pp391-400
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
Tan, J. Sack, B. K. Oyen, D. Piccoli, L. Barbieri, S. Foglierini, M. Fregni, C. S. Marcandalli, J. Jongo, S. Abdulla, S. Perez, L. Corradin, G. Varani, L. Sallusto, F. Sim, B. K. L. Hoffman, S. L. Kappe, S. H. I. Daubenberger, C. Wilson, I. A. Lanzavecchia, A.
in Nat Med (2018) Vol.24 pp401-407
* Tan J., Sack B. K., Oyen D., Zenklusen I., Piccoli L. contributed equally to this work.
Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
Yasinska, I. M. Ceccone, G. Ojea-Jimenez, I. Hussain, R. Siligardi, G. Berger, S. M. Fasler-Kan, E. Bardelli, M. Varani, L. Fiedler, W. Wellbrock, J. Raap, U. Gibbs, B. F. Calzolai, L. Sumbayev, V. V.
in Nanoscale (2018) Vol.10 pp5827-5833
Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection
Lloyd, K. A. Steen, J. Amara, K. Israelsson, L. Lundstrom, S. L. Zhou, D. Zubarev, R. A. Reed, E. Piccoli, L. Gabay, C. Lanzavecchia, A. Baeten, D. Lundberg, K. Mueller, D. L. Klareskog, L. Malmstrom, V. Gronwall, C.
in Eur J Immunol (2018) Vol.48 pp1030-1045
High mobility group box 1 (HMGB1) acts as an “alarmin” to promote acute myeloid leukaemia progression
Yasinska, I. M. Goncalves Silva, I. Sakhnevych, S. S. Hussain, R. Siligardi, G. Fiedler, W. Wellbrock, J. Bardelli, M. Varani, L. Raap, U. Berger, S. Gibbs, B. F. Fasler-Kan, E. Sumbayev, V. V.
in Oncoimmunology (2018) Vol.7 ppe1438109
Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides
Bergmann, T. J. Fregno, I. Fumagalli, F. Bertoni, F. Boersema, P. J. Picotti, P. Molinari, M.
in J Biol Chem (2018) Vol.293 pp5600-5612
Membrane lipid environment: Potential modulation of chemokine receptor function
Thelen, M. Legler, D. F.
in Cytokine (2018) Vol.109 pp72-75
Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion
Lindesmith, L. C. Mallory, M. L. Debbink, K. Brewer-Jensen, P. D. Swann, E. W. Sheahan, T. P. Graham, R. L. Beltramello, M. Corti, D. Lanzavecchia, A. Baric, R. S.
in mSphere (2018) Vol.3 ppe00518-17
A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
De Muyt, A. Pyatnitskaya, A. Andreani, J. Ramus, C. Laureau, R. Fernandez-Vega, A. Holoch, D. Girard, E. Govin, J. Margueron, R. Coute, Y. Cejka, P. Guerois, R. Borde, V.
in Genes Dev (2018) Vol.32 pp283-296
Methods to Study DNA End Resection I: Recombinant Protein Purification
Anand, R. Pinto, C. Cejka, P.
in Methods Enzymol (2018) Vol.600 pp25-66
Pillars Article: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994. 179:1109-1118
Sallusto, F. Lanzavecchia, A.
in J Immunol (2018) Vol.200 pp887-896
Dissecting human antibody responses: useful, basic and surprising findings
Lanzavecchia, A.
in EMBO Mol Med (2018) Vol. ppe8879
New insights in chemokine signaling
Legler, D. F. Thelen, M.
in F1000Res (2018) Vol.7 pp95
Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes
Ranjha, L. Howard, S. M. Cejka, P.
in Chromosoma (2018) Vol.127 pp187-214
Methods to Study DNA End Resection II: Biochemical Reconstitution Assays
Pinto, C. Anand, R. Cejka, P.
in Methods Enzymol (2018) Vol.600 pp67-106
Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans
Sallusto, F. Cassotta, A. Hoces, D. Lanzavecchia, A.
in Cold Spring Harb Perspect Biol (2017) Vol.10 ppa029421
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Chen, J. Guccini, I. Mitri, D. D. Revandkar, A. Sarti, M. Pasquini, E. Alajati, A. Pinton, S. Losa, M. Civenni, G. Catapano, C. V. Sgrignani, J. Cavalli, A. D'Antuono, R. Asara, J. M. Morandi, A. Chiarugi, P. Crotti, S. Agostini, M. Montopoli, M. Masgras, I. Rasola, A. Garcia-Escudero, R. Delaleu, N. Rinaldi, A. Bertoni, F. Bono, J. Carracedo, A. Alimonti, A.
in Nat Genet (2015) Vol.50 pp219-228

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