Publications Archive

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence
Revandkar, A. Perciato, M. L. Toso, A. Chen, J. Gerber, H. Dimitrov, M. Rinaldi, A. Delaleu, N. Pasquini, E. D'Antuono, R. Pinton, S. Losa, M. Gnetti, L. Arribas, A. Fraering, P. Bertoni, F. Nepveu, A. Alimonti, A.
in Nat Commun (2016) Vol.7 pp13719
Chemokines: Chemistry, Biochemistry and Biological Function
Legler, D. F. Thelen, M.
in Chimia (2016) Vol.70 pp856-859
IL-12 protects from psoriasiform skin inflammation
Kulig, P. Musiol, S. Freiberger, S. N. Gyulveszi, G. Russo, G. Pantelyushin, S. Kishihara, K. Alessandrini, F. Kundig, T. Sallusto, F. Hofbauer, G. F. Haak, S. Becher, B.
in Nat Commun (2016) Vol.7 pp13466
Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex
Wyszynski, R. W. Gibbs, B. F. Varani, L. Sumbayev, V. V.
in Cell Mol Immunol (2016) Vol.13 pp47-56
Development of a SYBR green I real-time PCR assay for specific identification of the fish pathogen Aeromonas salmonicida subspecies salmonicida
Fernandez-Alvarez, C. Gonzalez, S. F. Santos, Y.
in Appl Microbiol Biotechnol (2016) Vol.100 pp10585-10595
The C-terminal domain of TPX2 is made of alpha-helical tandem repeats
Sanchez-Pulido, L. Perez, L. Kuhn, S. Andrade-Navarro, M. A.
in BMC Struct Biol (2016) Vol.16 pp17
Perez L. and Sanchez-Pulido L. contributed equally to this work.
Quality control mechanisms of protein biogenesis: proteostasis dies hard
Bergmann, T. J. Brambilla Pisoni, G. Molinari, M.
in AIMS Biophysics (2016) Vol.3 pp456-478
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Geiger, R. Rieckmann, J. C. Wolf, T. Feng, Y. Fuhrer, T. Kogadeeva, M. Picotti, P. Meissner, F. Mann, M. Zamboni, N. Sallusto, F. Lanzavecchia, A.
in Cell (2016) Vol.167 pp829-842 e13
Geiger R. and Lanzavecchia A are co-corresponding authors.
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
Fumagalli, F. Noack, J. Bergmann, T. J. Pisoni, G. B. Fasana, E. Fregno, I. Galli, C. Loi, M. Solda, T. D'Antuono, R. Raimondi, A. Jung, M. Melnyk, A. Schorr, S. Schreiber, A. Simonelli, L. Varani, L. Wilson-Zbinden, C. Zerbe, O. Hofmann, K. Peter, M. Quadroni, M. Zimmermann, R. Molinari, M.
in Nat Cell Biol (2016) Vol.18 pp1173-1184
Fumagalli, F. , Noack J. and Bergmann T. contributed equally to this work. * Recommended by the Faculty of 1000
Post ER Quality Control: A Role for UDP-Glucose:Glycoprotein Glucosyl Transferase and p97
Fregno, I. Molinari, M.
in J Rare Dis Res & Treatment (2016) Vol.1 pp40-42
In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism
Baj-Rossi, C. Cavallini, A. Kilinc, E. G. Rezzonico Jost, T. Proietti, M. De Micheli, G. Grassi, F. Dehollain, C. Carrara, S.
in IEEE Trans Biomed Circuits Syst (2016) Vol.10 pp955-962
RAGs and BUGS: an alliance for autoimmunity
Rigoni, R. Grassi, F. Villa, A.
in Gut Microbes (2016) Vol.7 pp503-511
Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
Kallewaard, N. L. Corti, D. Collins, P. J. McAuliffe, J. M. Benjamin, E. Wachter-Rosati, L. Palmer-Hill, F. J. Yuan, A. Q. Walker, P. A. Vorlaender, M. K. Bianchi, S. Guarino, B. De Marco, A. Vanzetta, F. Agatic, G. Foglierini, M. Pinna, D. Fernandez-Rodriguez, B. Fruehwirth, A. Silacci, C. Ogrodowicz, R. W. Martin, S. R. Sallusto, F. Suzich, J. A.Lanzavecchia, A. Zhu, Q. Gamblin, S. J. Skehel, J. J.
in Cell (2016) Vol.166 pp596-608
The Dynamic Basis for Signal Propagation in Human Pin1-WW
Olsson, S. Strotz, D. Vogeli, B. Cavalli, A.
in Structure (2016) Vol.24 pp1464-75
S. Olsson and A. Cavalli are co-corresponding authors.
Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
Stettler, K. Beltramello, M. Espinosa, D. A. Cassotta, A. Bianchi, S. Vanzetta, F. Minola, A. Jaconi, S. Mele, F. Foglierini, M. Pedotti, M. Simonelli, L. Dowall, S. Atkinson, B. Percivalle, E. Simmons, C. P. Varani, L. Blum, J. Baldanti, F. Cameroni, E. Hewson, R. Harris, E. Lanzavecchia, A. Sallusto, F.Corti, D.
in Science (2016) Vol.353 pp823-6
K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
Ellebrecht, C. T. Bhoj, V. G. Nace, A. Mao, X. Cho, M. J. Di Zenzo, G. Lanzavecchia, A. Seykora, J. T. Cotsarelis, G. Milone, M. C. Payne, A. S.
in Science (2016) Vol.353 pp179-84
The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells
Goncalves Silva, I. Ruegg, L. Gibbs, B. F. Fruehwirth, A. Varani, L. Berger, S. M. Fasler-Kan, E. Sumbayev, V. V.
in Oncoimmunology (2016) Vol.5 ppe1195535
Promoting immunology: The future is here
Colmone, A. C. Sallusto, F. Abbas, A. K.
in Sci Immunol (2016) Vol.1 ppaag2713
Antibody-guided vaccine design: identification of protective epitopes
Lanzavecchia, A. Fruhwirth, A. Perez, L.
in Curr Opin Immunol (2016) Vol.41 pp62-67
Enzymatic and Inhibition Mechanism of Human Aromatase (CYP19A1) Enzyme. A Computational Perspective from QM/MM and Classical Molecular Dynamics Simulations
Sgrignani, J. Cavalli, A. Colombo, G.
in Mini Rev Med Chem (2016) Vol.16 pp1112-24
Altered CXCL12 expression reveals a dual role of CXCR4 in osteosarcoma primary tumor growth and metastasis
Neklyudova, O. Arlt, M. J. Brennecke, P. Gvozdenovic, A. Kuzmanov, A. Robl, B. Botter, S. M. Born, W. Fuchs, B.
in J Cancer Res Clin Oncol (2016) Vol.142 pp1739-1750
Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
Kabanova, A. Marcandalli, J. Zhou, T. Baxa, U. Tsybovsky, Y. Lilleri, D. Silacci-Fregni, C. Foglierini, M. Fernandez-Rodriguez, B. M. Druz, A. Zhang, B. Geiger, R. Pagani, M. Sallusto, F. Kwong, P. D. Corti, D. Lanzavecchia, A. Perez, L.
in Nat Microbiol (2016) Vol.1 pp16082
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou equally contributed to this work; Antonio Lanzavecchia1and Laurent Perez jointly supervised this work.
Modulation of Chemokine Responses: Synergy and Cooperativity
Proudfoot, A. E. Uguccioni, M.
in Front Immunol (2016) Vol.7 pp183
Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1beta production by myeloid cells
Ronchi, F. Basso, C. Preite, S. Baumjohann, D. Perlini, L. Lanzavecchia, A. Sallusto, F.
in Nat Commun (2016) Vol.7 pp11541
Francesca Ronchi and Camilla Basso equally contributed to this work.
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities
Montagner, S. Leoni, C. Emming, S. Balestrieri, C. Barozzi, I. Piccolo, V. Togher, S. Ko, M. Rao, A. Natoli, G. Monticelli, S.
in Cell Rep (2016) Vol.15 pp1566-79
Monoclonal antibodies to different components of the human cytomegalovirus (HCMV) pentamer gH/gL/pUL128L and trimer gH/gL/gO as well as antibodies elicited during primary HCMV infection prevent epithelial cell syncytium formation
Gerna, G. Percivalle, E. Perez, L. Lilleri, D.
in J Virol (2016) Vol.90 pp6216-23
Follicular helper T-cells and virus-specific antibody response in primary and reactivated human cytomegalovirus infections of the immunocompetent and immunocompromised transplanted patients
Bruno, F. Fornara, C. Zelini, P. Carrara, E. Scaramuzzi, L. Cane, I. Mele, F. Sallusto, F. Lilleri, D. Gerna, G.
in J Gen Virol (2016) Vol.97 pp1928-41
Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome
Corti, D. Passini, N. Lanzavecchia, A.
in J Infect Public Health (2016) Vol.9 pp231-5
The Human Vaccines Project: A roadmap for cancer vaccine development
Romero, P. Banchereau, J. Bhardwaj, N. Disis, M. L. Dranoff, G. Gilboa, E. Hammond, S. A. Hershberg, R. Korman, A. J. Kvistborg, P. Melief, C. Mellman, I. Palucka, A. K. Redchenko, I. Robins, H. Sallusto, F. Schenkelberg, T. Schoenberger, S. Sosman, J. Tureci, O. Van den Eynde, B. Koff, W. Coukos, G.
in Sci Transl Med (2016) Vol.8 pp334ps9
Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis
De Benedictis, P. Minola, A. Rota Nodari, E. Zecchin, B. Salomoni, A. Foglierini, M. Agatic, G. Vanzetta, F. Lavenir, R. Lepelletier, A. Bentley, E. Weiss, R. Cattoli, G. Capua, I. Sallusto, F. Wright, E. Lanzavecchia, A. Bourhy, H. Corti, D.
in EMBO Mol Med (2016) Vol.8 pp407-21
Paola De Benedictis and Andrea Minola equally contributed to this work.
SARS-like WIV1-CoV poised for human emergence
Menachery, V. D. Yount, B. L., Jr. Sims, A. C. Agnihothram, S. S. Gralinski, L. E. Graham, R. L. Scobey, T. Plante, J. A. Royal, S. R. Swanstrom, J. Sheahan, T. P. Pickles, R. J. Corti, D. Randell, S. H. Lanzavecchia, A. Marasco, W. A. Baric, R. S.
in Proc Natl Acad Sci U S A (2016) Vol.113 pp3048-53
Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis
Ferreira, T. P. Mariano, L. L. Ghilosso-Bortolini, R. Fernandes, A. J. Berni, M. Cecchinato, V. Uguccioni, M. Maj, R. Barberis, A. Silva, P. M. Martins, M. A.
in Front Immunol (2016) Vol.7 pp95
Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia
Jost, T. R. Borga, C. Radaelli, E. Perruzza, L. Omodho, L. Cazzaniga, G. Biondi, A. Indraccolo, S. Thelen, M. Te Kronnie, G. Grassi, F.
in J Leukoc Biol (2016) Vol.99 pp1077-87
Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects
Rigoni, R. Fontana, E. Guglielmetti, S. D'Erchia, A. M. Maina, V. Taverniti, V. Castiello, M. C. Mantero, S. Pacchiana, G. Musio, S. Pedotti, R. Selmi, C. Mora, J. R. Pesole, G. Vezzoni, P. Poliani, P. L. Grassi, F. Villa, A. Cassani, B.
in J Exp Med (2016) Vol.213 pp355-75
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
Corti, D. Misasi, J. Mulangu, S. Kanekiyo, M. Wollen, S. Ploquin, A. Doria-Rose, N. A. Staupe, R. P. Bailey, M. Shi, W. Choe, M. Marcus, H. Thompson, E. A. Cagigi, A. Silacci, C. Fernandez-Rodriguez, B. Perez, L. Sallusto, F. Vanzetta, F. Agatic, G. Cameroni, E. Kisalu, N. Gordon, I. Ledgerwood, J. E.Mascola, J. R. Graham, B. S. Muyembe-Tamfun, J. J. Trefry, J. C. Lanzavecchia, A.
in Science (2016) Vol.351 pp1339-42
Davide Corti and John Misasi equally contributed to this work; John C. Trefry, Antonio Lanzavecchia, and Nancy J. Sullivan equally contributed to this work.
Structural and molecular basis for Ebola virus neutralization by protective human antibodies
Misasi, J. Gilman, M. S. Kanekiyo, M. Cagigi, A. Mulangu, S. Corti, D. Ledgerwood, J. E. Lanzavecchia, A. Cunningham, J. Muyembe-Tamfun, J. J. Baxa, U. Graham, B. S. Xiang, Y. Sullivan, N. J. McLellan, J. S.
in Science (2016) Vol.351 pp1343-6
John Misasi, Morgan S. A. Gilman, Masaru Kanekiyo, Miao Gui, equally contributed to this work; Ye Xiang, Nancy J. Sullivan, Jason S. McLellan equally contributed to this work.
Five Questions (with their Answers) on ER-Associated Degradation
Brambilla Pisoni, G. Molinari, M.
in Traffic (2016) Vol.17 pp341-50
T-cell epitope conservation across allergen species is a major determinant of immunogenicity
Westernberg, L. Schulten, V. Greenbaum, J. A. Tripple, V. McKinney, D. M. Frazier, A. Hofer, H. Wallner, M. Sallusto, F. Sette, A. Peters, B.
in J Allergy Clin Immunol (2016) Vol.138 pp571-578
Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma
Jacquelot, N. Enot, D. P. Flament, C. Blattner, C. Pitt, J. M. Yamazaki, T. Roberti, M. P. Daillere, R. Vetizou, M. Poirier-Colame, V. Semeraro, M. Caignard, A. Slingluff, C. L., Jr. Sallusto, F. Rusakiewicz, S. Weide, B. Marabelle, A. Kohrt, H. Dalle, S. Cavalcanti, A. Kroemer, G. Di Giacomo, A. M. Maio, M. Wong, P. Yuan, J. Wolchok, J. Umansky, V. Eggermont, A. Zitvogel, L.
in J Clin Invest (2016) Vol.126 pp921-37
Metainference: A Bayesian inference method for heterogeneous systems
Bonomi, M. Camilloni, C. Cavalli, A.
in Science Advances (2016) Vol.2 ppe1501177
Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling
Filipello, F. Pozzi, D. Proietti, M. Mazzitelli, S. Matteoli, M. Verderio, C. Grassi, F.
in Oncotarget (2016) Vol.7 pp5143-56
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
Tan, J. Pieper, K. Piccoli, L. Foglierini, M. Geiger, R. Tully, C. M. Jarrossay, D. Ndungu, F. M. Wambua, J. Bejon, P. Fregni, C. S. Fernandez-Rodriguez, B. Barbieri, S. Bianchi, S. Marsh, K. Thathy, V. Corti, D. Sallusto, F. Bull, P. Lanzavecchia, A.
in Nature (2016) Vol.529 pp105-9
Joshua Tan, Kathrin Pieper, Luca Piccoli equally contributed to this work and Peter Bull and Antonio Lanzavecchia jointly supervised this work.
The Exact NOE as an Alternative in Ensemble Structure Determination
Vogeli, B. Olsson, S. Guntert, P.
in Biophys J (2016) Vol.110 pp113-26
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J. Molinari, M. et al.
in Autophagy (2016) Vol.12 pp1-222
Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking
Cecchinato, V. D'Agostino, G. Raeli, L.
in J Leukoc Biol (2015) Vol.99 pp851-5
Monitoring Scavenging Activity of Chemokine Receptors
Moepps, B. Thelen, M.
in Methods Enzymol (2015) Vol.570 pp87-118
Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets
Karin, N. Wildbaum, G. Thelen, M.
in J Leukoc Biol (2015) Vol.99 pp857-62
Association of eukaryotic translation initiation factor eIF2B with fully solubilized CXCR4
Palmesino, E. Apuzzo, T. Thelen, S. Langen, H. Thelen, M.
in J Leukoc Biol (2015) Vol.99 pp971-8
LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance
Ziegler, P. Boettcher, S. Takizawa, H. Brummendorf, T. H.
in Ann Hematol (2015) Vol.95 pp173-8
Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments
Campana, R. Moritz, K. Marth, K. Huber, H. Henning, R. Blatt, K. Hoermann, G. Brodie, T. M. Kaider, A. Valent, P. Sallusto, F. Wohrl, S. Valenta, R.
in J Allergy Clin Immunol (2015) Vol.137 pp601-609 e8
Heterogeneity of Human CD4(+) T Cells Against Microbes
Sallusto, F.
in Annu Rev Immunol (1970) Vol.34 pp317-34

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