New Study Reveals Alternative Pathways for Clearing Misfolded Proteins in Rare Diseases
Rare diseases like the deficiency of alpha1-antitrypsin or lysosomal storage disorders are caused by degradation of mutant proteins. In their latest study published in EMBO Reports, Elisa Fasana, Ilaria Fregno, Carmela Galli and Tatiana Soldà in the group led by Maurizio Molinari elucidate the pathways that ensure the clearance of misfolded proteins, when the major […]
Freeze Forward: Advancing from Room Temperature to Cryo-EM Applications
Explore diverse tools and resources to go beyond conventional electron microscopy (EM) to cryo-EM together with Thermo Fisher Scientific and Bios⁺ Bellinzona.
Probing monoclonal antibody specificity for therapeutic vaccines design
IRB Special Seminar Prof. Dr. Martin Bachmann Department of Immunology, Inselspital, University of Bern, Bern Friday, 31 May 2024 at 12 pm Bios+ Seminar Room Contact: Prof. Roger Geiger
P2rx7 in aging of the intestinal stem cell niche
IRB Special Seminar Prof. Matthias Schewe Medical faculty of Heidelberg University, (GER) Thursday, May 23, 2024 at 12:00 pm Bios+ Seminar Room Contact: Prof. Fabio Grassi
Mechanism of DNA unwinding by MCM8-9 in complex with HROB
In a new study published in “Nature Communications” the Cejka laboratory and collaborators identified the molecular mechanisms by which the HROB protein enhances the DNA unwinding function of the MCM8-9 helicase, crucial for DNA repair and replication processes. Bellinzona, May 2, 2024 – The MCM8-9 helicase and the HROB proteins function together in DNA repair. […]
Bios+ Open Day
The Institute for Research in Biomedicine (IRB), the Institute of Oncology Research (IOR) and the laboratories for translational research of the EOC invite you to the open day that will take place on Saturday May 25th from 9:00 a.m. to 1:00 p.m at Bios+ (Via Francesco Chiesa 5, 6500 Bellinzona). This is an opportunity to […]
Bios+ Open Day
The Institute for Research in Biomedicine (IRB), the Institute of Oncology Research (IOR) and the laboratories for translational research of the EOC invite you to the open day that will take place on Saturday May 25th from 9:00 a.m. to 1:00 p.m at Bios+ (Via Francesco Chiesa 5, 6500 Bellinzona). This is an opportunity to […]
The ocean microbiome as a genomic treasure trove
Prof. Shinichi Sunagawa Department of Biology, Institute of Microbiology, ETH Zurich Thursday, May 23, 2024 at 4:00 pm Bios+ Seminar Room Contact: Prof. Davide Robbiani This event is supported by the IRB-Rockefeller University partnership for infectious disease research.
Transformer-based spatial-temporal detection of apoptotic cell death in live-cell imaging
Apoptotic cell death is a crucial mechanism that contributes to tissue homeostasis and prevents the onset of several diseases. However, this phenomenon is challenging to identify within microscopy movies that can encompass thousands of cells. Led by Santiago Gonzalez, the recent study carried at the IRB in Bellinzona introduces ADeS, an innovative approach based on […]
Bones & beyond: Uncovering the ossification and cytotoxic role of CD8 T cells in ankylosing spondylitis
A recent study, published in RMD Open, by Martini et al. has identified, in patients with ankylosing spondylitis (AS), high cytotoxic CD8 T cells upregulating chemokine receptors along with genes promoting the ossification process, paving the way to new therapeutic targets for the treatment of AS. Bellinzona, April 15, 2024 – Ankylosing spondylitis (AS) is […]
