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A new study characterizes the role of the heterocomplex CXCL12/HMGB1 in cancer cells

Bellinzona – June 14 2024 – Despite the established roles of both HMGB1 and CXCL12 in tumour progression and metastatic spread to distal sites, the role of the CXCL12/HMGB1 heterocomplex in cancer has never been investigated. In the study, published in Frontiers in Immunology by Pirani et al., a new mass spectrometry protocol was established […]

Mechanism of Mre11 Activation by Sae2/CtIP Unveiled: Insights from AlphaFold2, Biochemical, and Genetic Assays

Bellinzona – June 13 2024 – A new study published by the Cejka laboratory and collaborators in “Molecular Cell” provides molecular insight into the activation of Mre11-Rad50- endonuclease activity by Sae2/CtIP. In Saccharomyces cerevisiae (S. cerevisiae), Mre11-Rad50-Xrs2 (MRX)-Sae2 nuclease activity is required for the resection of DNA breaks with secondary structures or protein blocks, while in […]

New SNSF grants awarded to four IRB researchers

Bellinzona – June 11 2024 – The Swiss National Science Foundation (SNSF) has recently awarded SNSF grants to four researchers at the Institute for Research in Biomedicine (IRB, affiliated to Università della Svizzera italiana): Valentina Cecchinato, Greta Guarda, Maurizio Molinari, and Silvia Monticelli. Valentina Cecchinato, research associate hosted in the group of Mariagrazia Uguccioni, focuses […]

New study characterizes the role of selected RNA-binding proteins in immune cells

A new study was published in Life Science Alliance by the Monticelli lab. The study characterizes the role of RNA-binding proteins in modulating mast cell functions, and was spearheaded by Marian Bataclan and Cristina Leoni, in collaboration with the Heissmeyer lab (LMU Munich). Bellinzona, June 06, 2024 – Mast cells are crucial components of our […]

Comel Foundation supports IRB predoctoral program and a research project

Bellinzona – June 5, 2024 – The Institute for Research in Biomedicine (IRB, affiliated with the University of Italian Switzerland) is pleased to announce the support of the Comel Foundation for two important initiatives The first involves the creation of a predoctoral program, in which selected Swiss and international candidates receive a fellowship for up […]

New Study Reveals Alternative Pathways for Clearing Misfolded Proteins in Rare Diseases

Rare diseases like the deficiency of alpha1-antitrypsin or lysosomal storage disorders are caused by degradation of mutant proteins. In their latest study published in EMBO Reports, Elisa Fasana, Ilaria Fregno, Carmela Galli and Tatiana Soldà in the group led by Maurizio Molinari elucidate the pathways that ensure the clearance of misfolded proteins, when the major […]