Archives

Researchers from IRB discovered the function of the BRCA1 anti-cancer protein

Despite the known involvement of the BRCA1 protein in breast and ovarian cancer prevention, its precise function was poorly understood. A new study from the Cejka laboratory published in Nature shows that BRCA1 directly functions in DNA break repair by Homologous Recombination, preventing genetic instability. Bellinzona – September 11 2024 – Mutations in the BRCA1 […]

Human Immunity: One Cell At A Time

International PhD Program in Immunology, Cell Biology and Biochemistry 2024/2025 Prof. Sarah Teichmann Cambridge Stem Cell Institute – UK Thursday, 26 September 2024 at 12 pm Bios+ Seminar Room Contact: Dr. Silvia Monticelli

Protein Phase Separation in Immunology and Aging

IRB Special Seminar Dr. Gea Silvia Sofia Cereghetti Centre for Misfolding Diseases, Department of Chemistry University of Cambridge Tuesday, 10 September 2024 at 11 am  Bios+ Seminar Room  

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms

A paper published in the journal “Nature Communications” by the Sugimoto, Shinohara and Cejka laboratories shows how Sae2 regulates the nuclease activity of the MRX complex to initiate Homologous Recombination mediated rep​air of DNA breaks. Bellinzona – July 26 2024 – DNA double-strand breaks (DSBs) are a threat for genome integrity and cell survival and […]

Immunity and Metabolism go viral

IRB Special Seminar Dr. Samuel Nobs Department of Systems Immunology, Weizmann Institute of Science Wednesday, 28 August 2024 at 1.30 pm Bios+ Seminar Room    

HLTF removes Cas9 from DNA breaks

A paper published in the journal “Nature Communications” by the Cejka laboratory shows that the HLTF, a protein known to remodel replication forks, can unexpectedly dislocate Cas9 from the DNA after cleavage to initiate DNA double-stranded break repair. Bellinzona – July 10 2024 – During gene editing, the repair of DNA double-stranded breaks generated with […]