Multiple sclerosis therapy: scientists identify the Achilles’ heel of a therapeutic antibody and find a solution to avoid the problem
on September 11, 2019 An international research team led by the Institute for Research in Biomedicine, affiliated to the Università della Svizzera italiana, has discovered why some patients with multiple sclerosis make an immune reaction that curtails the effectiveness of natalizumab, a therapeutic antibody used for the treatment of the disease and used this information […]
Sabrina Casella awarded PhD
on September 4, 2019 Sabrina Casella successfully defended her PhD thesis, which was presented at the Institute for Research in Biomedicine (IRB) of Bellinzona (CH) on August 27th, 2019. Her thesis title was “The biochemistry of ACKR3 and its role in diffuse large B cell lymphoma” and the study was conducted in the Signal Transduction […]
Identification of SIGN-R1 as responsible of influenza virus recognition
on July 29, 2019 A team of researchers from the Institute for Research in Biomedicine (IRB, affiliated to USI Università della Svizzera italiana, Switzerland) have discovered and identified a molecule – SIGN-R1 – capable of recognizing the multiple variants of influenza and consequently ‘directing’ the immune response in individuals affected by the disease. The results […]
Gain Therapeutics SA Announces Award Notification of a €1.4M Grant Support from Eurostars-2 together with the Institute for Research in Biomedicine and Neuro-Sys SAS after having scored 2nd among 325 Eligible Applications
on July 23, 2019 Gain Therapeutics SA, a biotechnology company discovering and developing novel therapeutics to target lysosomal enzymes involved in inborn errors of metabolism and in central nervous system (CNS) diseases, today announced that together with Dr. Maurizio Molinari from the Institute for Research in Biomedicine, Bellinzona (Switzerland) affiliated to the Università della Svizzera […]
New paper from the Cavalli and Uguccioni labs: Oxidation state dependent conformational changes of HMGB1 regulate the formation of the CXCL12/HMGB1 heterocomplex
on July 22, 2019 High-mobility Group Box 1 (HMGB1) is an abundant protein present in all mammalian cells and involved in several processes. During inflammation or tissue damage, HMGB1 is released in the extracellular space and, depending on its redox state, can form a heterocomplex with CXCL12. The heterocomplex acts exclusively on the chemokine receptor […]
Rafet Ameti awarded PhD
on July 15, 2019 Rafet Ameti successfully defended his PhD thesis, which was presented at the Institute for Research in Biomedicine (IRB) of Bellinzona (CH) on July 8th, 2019. His thesis title was “Role of ACKR3 in leukocyte migration and the microarchitecture of mouse spleen” and the study was conducted in the Signal Transduction lab […]
New paper from the Grassi lab: a regulated intestinal immune response against Lactobacillus is important for metabolic homeostasis of the organism
on July 8, 2019 Our gastrointestinal tract is colonized by bacteria at birth, and, thereafter, a mutualistic interaction with the evolving microbiota is established. The microbiota regulates the metabolic balance of the organism by generating bioactive molecules that are absorbed through the intestinal epithelium. In addition, it stimulates the development of the gut-associated lymphoid tissue […]
Davide Robbiani appointed future Director of the IRB
on June 18, 2019 The Foundation Council of the Institute for Research in Biomedicine and the University Council of Università della Svizzera italiana have appointed Prof. Davide Robbiani as the future Director of the IRB and Full Professor of USI Faculty of Biomedical Sciences. Prof. Robbiani will succeed Prof. Antonio Lanzavecchia as of July 1st, […]
Federica Sallusto awarded with the “I numeri uno” Prize
on June 5, 2019 The “I numeri uno” prize of the Camera di commercio italiana in Switzerland has been awarded to the Arch. Mario Botta, to Prof. Federica Sallusto of the IRB affiliated to the Università della Svizzera italiana (USI), to the President of the Associazione Ospedale Italiano Gianni Macconi and to the Artistic Director […]
New paper from the Molinari Lab
on May 17, 2019 Maurizio Molinari (IRB), Lawrence Wrabetz (Hunter James Kelly Research Institute, University at Buffalo, Buffalo, New York, USA) and Maurizio D’Antonio (San Raffaele Scientific Institute, Milan Italy) research groups have recently published an article in PLOS Genetics entitled “Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination”. […]
