The role of beta-arrestins in CXCL12/HMGB1-mediated signaling

The ability of chemokines to form heterocomplexes with other chemokines or HMGB1 represents an additional level of regulation for shaping their function by enhancing their potency on their cognate receptor. In recent years, the relevance of the CXCL12/HMGB1 heterocomplex activity, on the chemokine receptor CXCR4, has been widely demonstrated in models of inflammation and tissue […]

New research from Ticino on the antibody response to SARS-CoV-2

After the announcement, in May, of the first results of serological tests carried out on healthcare personnel in Ticino, significant data on the antibody response to SARS-CoV-2 is now available, thanks to the analysis carried out – among others – by the Institute for Research in Biomedicine (IRB, affiliated to USI) and Humabs BioMed (subsidiary […]

Fibroblast causalities in chronic inflammation and cancer

From: Member of the Academy of Athens. Director, Department of Physiology, Medical School, University of Athens. Associate Researcher, Biomedical Sciences Research Center ‘Alexander Fleming’ Host contact: Santiago González Date: 6.11.2020 10:00 Speakers: George Kollias Virtual Conference

Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab

When our DNA breaks, cells use the homologous recombination pathway to accurately repair the break, so that DNA is fixed and no mutations are introduced during the repair process. When multiple DNA molecules are broken, the recombination factors use a smart strategy to join only the DNA pieces originating from the same DNA molecules. This […]

Antonino Cassotta awarded PhD

Antonino Cassotta successfully defended his PhD thesis, which was presented at the Eidgenössische Technische Hochschule (ETH) Zurich on 6th February 2020. His thesis title was “Clonal selection and immunodominance in the human T cell response to microbial antigens and biologicals” and the study was conducted in the Cellular Immunology lab headed by Prof. Federica Sallusto […]