on May 4, 2016
A new article published in Cell Reports describes how an enzyme involved in regulating DNA demethylation processes impacts differentiation and proliferation of mast cells. TET2 is an enzyme involved in the regulation of DNA methylation dynamics that is frequently found mutated in myeloid malignancies such as systemic mastocytosis. This study, mainly performed by a PhD student, Sara Montagner, uncovers transcriptional pathways regulated by TET2 and identifies both enzymatic activity-dependent and -independent functions of TET2, shedding new light on potential mechanisms underlying the malignant transformation of mast cells.
This study was made possible by the help of outstanding collaborators, by funding from the Swiss National Science Foundation (SNSF) and the San Salvatore Foundation, and by contributions from the Novartis Foundation and the Ceresio Foundation. Sara is now continuing her studies in the same lab thanks to the support of a Marie Heim-Vögtlin (MHV) fellowship.
Article:
Montagner, S., C. Leoni, S. Emming, G. Della Chiara, C. Balestrieri, I. Barozzi, V. Piccolo, S. Togher, M. Ko, A. Rao, G. Natoli and S. Monticelli
Cell Rep. 2016; 15:1566-1579.