Sgrignani Jacopo, PhD

Publications

• A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers
  Spriano, F. Sartori, G. Sgrignani, J. Barnabei, L. Arribas, A. J. Guala, M. Del Amor, A. M. C. Tomasso, M. R. Tarantelli, C. Cascione, L. Golino, G. Riveiro, M. E. Bortolozzi, R. Lupia, A. Paduano, F. Huguet, S. Rezai, K. Rinaldi, A. Margheriti, F. Ventura, P. Guarda, G. Costa, G. Rocca, R. Furlan, A. Verdonk, L. M. Innocenti, P. Martin, N. I. Viola, G. Driessen, C. Zucca, E. Stathis, A. Gahtory, D. Van den Nieuwboer, M. Bornhauser, B. Alcaro, S. Trapasso, F. Cristobal, S. Padrick, S. B. Pazzi, N. Cavalli, F. Cavalli, A. Gaudio, E. Bertoni, F.
  in Haematologica (2024) Vol.109 pp3602-3614
  
• PI3Kdelta activation, IL6 overexpression, and CD37 loss cause resistance to naratuximab emtansine in lymphomas
  Arribas, A. J. Napoli, S. Gaudio, E. Herbaux, C. Cannas, E. Tarantelli, C. Bordone Pittau, R. Cascione, L. Munz, N. Aresu, L. Sgrignani, J. Rinaldi, A. Kwee, I. Rossi, D. Cavalli, A. Zucca, E. Stussi, G. Stathis, A. Sloss, C. Davids, M. S. Bertoni, F.
  in Blood Adv (2024) Vol.8 pp6268-6281
  
• Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease
  Rampias, T. Antoniou, T. Stevaert, A. Kravariti, L. Van Loy, B. Vandeput, J. Sgrignani, J. Filippidou, N. Locatelli, P. Samiotaki, M. Tzakos, E. P. Cavalli, A. Naesens, L. Sideris, D. C. Tzakos, A. G.
  in Eur J Med Chem (2024) Vol.279 pp116886
  
• Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice
  Zumerle, S. Sarill, M. Saponaro, M. Colucci, M. Contu, L. Lazzarini, E. Sartori, R. Pezzini, C. Rinaldi, A. Scanu, A. Sgrignani, J. Locatelli, P. Sabbadin, M. Valdata, A. Brina, D. Giacomini, I. Rizzo, B. Pierantoni, A. Sharifi, S. Bressan, S. Altomare, C. Goshovska, Y. Giraudo, C. Luisetto, R. Iaccarino, L. Torcasio, C. Mosole, S. Pasquini, E. Pellegrini, L. Peron, G. Fassan, M. Masiero, S. Giori, A. M. Dall'Acqua, S. Auwerx, J. Cippa, P. Cavalli, A. Bolis, M. Sandri, M. Barile, L. Montopoli, M. Alimonti, A.
  in Nat Aging (2024) Vol.4 pp1231-1248
  
• A first-in-class Wiskott-Aldrich syndrome protein activator with anti-tumor activity in hematologic cancers
  Spriano, F. Sartori, G. Sgrignani, J. Barnabei, L. Arribas, A. J. Guala, M. Del Amor, A. M. C. Tomasso, M. R. Tarantelli, C. Cascione, L. Golino, G. Riveiro, M. E. Bortolozzi, R. Lupia, A. Paduano, F. Huguet, S. Rezai, K. Rinaldi, A. Margheriti, F. Ventura, P. Guarda, G. Costa, G. Rocca, R. Furlan, A. Verdonk, L. M. Innocenti, P. Martin, N. I. Viola, G. Driessen, C. Zucca, E. Stathis, A. Gahtory, D. Van den Nieuwboer, M. Bornhauser, B. Alcaro, S. Trapasso, F. Cristobal, S. Padrick, S. B. Pazzi, N. Cavalli, F. Cavalli, A. Gaudio, E. Bertoni, F.
  in Haematologica (2024) Vol. pp
  
• Computational Design of Novel Cyclic Peptides Endowed with Autophagy-Inhibiting Activity on Cancer Cell Lines
  Albani, M. Fassi, E. M. A. Moretti, R. M. Garofalo, M. Montagnani Marelli, M. Roda, G. Sgrignani, J. Cavalli, A. Grazioso, G.
  in Int J Mol Sci (2024) Vol.25 pp4622
  
• ETS1 phosphorylation at threonine 38 is associated with the cell of origin of diffuse large B cell lymphoma and sustains the growth of tumour cells
  Chung, E. Y. L. Sartori, G. Ponzoni, M. Cascione, L. Priebe, V. Xu-Monette, Z. Y. Fang, X. Zhang, M. Visco, C. Tzankov, A. Rinaldi, A. Sgrignani, J. Zucca, E. Rossi, D. Cavalli, A. Inghirami, G. Scott, D. W. Young, K. H. Bertoni, F.
  in Br J Haematol (2023) Vol. pp
  
• Tau protein binds to the P53 E3 ubiquitin ligase MDM2
  Sola, M. Rendon-Angel, A. Rojo Martinez, V. Sgrignani, J. Magrin, C. Piovesana, E. Cavalli, A. Paganetti, P. Papin, S.
  in Sci Rep (2023) Vol.13 pp10208
  
• Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid
  Ratti, A. Fassi, E. M. A. Forlani, F. Mori, M. Villa, F. Cappitelli, F. Sgrignani, J. Roda, G. Cavalli, A. Villa, S. Grazioso, G.
  in Pharmaceutics (2023) Vol.15 pp
  
• Esmethadone-HCl (REL-1017): a promising rapid antidepressant
  Fava, M. Stahl, S. M. De Martin, S. Mattarei, A. Bettini, E. Comai, S. Alimonti, A. Bifari, F. Pani, L. Folli, F. Guidetti, C. Furlan, A. Sgrignani, J. Locatelli, P. Cavalli, A. O'Gorman, C. Traversa, S. Inturrisi, C. E. Pappagallo, M. Manfredi, P. L.
  in Eur Arch Psychiatry Clin Neurosci (2023) Vol. pp
  
• Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
  Muri, J. Cecchinato, V. Cavalli, A. Shanbhag, A. A. Matkovic, M. Biggiogero, M. Maida, P. A. Moritz, J. Toscano, C. Ghovehoud, E. Furlan, R. Barbic, F. Voza, A. De Nadai, G. Cervia, C. Zurbuchen, Y. Taeschler, P. Murray, L. A. Danelon-Sargenti, G. Moro, S. Gong, T. Piffaretti, P. Bianchini, F. Crivelli, V. Podesvova, L. Pedotti, M. Jarrossay, D. Sgrignani, J. Thelen, S. Uhr, M. Bernasconi, E. Rauch, A. Manzo, A. Ciurea, A. Rocchi, M. B. L. Varani, L. Moser, B. Bottazzi, B. Thelen, M. Fallon, B. A. Boyman, O. Mantovani, A. Garzoni, C. Franzetti-Pellanda, A. Uguccioni, M. Robbiani, D. F.
  in Nat Immunol (2023) Vol.24 pp604-611.
  
• Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein
  Bianchini, F. Crivelli, V. Abernathy, M. E. Guerra, C. Palus, M. Muri, J. Marcotte, H. Piralla, A. Pedotti, M. De Gasparo, R. Simonelli, L. Matkovic, M. Toscano, C. Biggiogero, M. Calvaruso, V. Svoboda, P. Cervantes Rincon, T. Fava, T. Podesvova, L. Shanbhag, A. A. Celoria, A. Sgrignani, J. Stefanik, M. Honig, V. Pranclova, V. Michalcikova, T. Prochazka, J. Guerrini, G. Mehn, D. Ciabattini, A. Abolhassani, H. Jarrossay, D. Uguccioni, M. Medaglini, D. Pan-Hammarstrom, Q. Calzolai, L. Fernandez, D. Baldanti, F. Franzetti-Pellanda, A. Garzoni, C. Sedlacek, R. Ruzek, D. Varani, L. Cavalli, A. Barnes, C. O. Robbiani, D. F.
  in Sci Immunol (2023) Vol. ppeade0958
  
• A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity
  Roehlen, N. Saviano, A. El Saghire, H. Crouchet, E. Nehme, Z. Del Zompo, F. Juhling, F. Oudot, M. A. Durand, S. C. Duong, F. H. T. Cherradi, S. Gonzalez Motos, V. Almeida, N. Ponsolles, C. Heydmann, L. Ostyn, T. Lallement, A. Pessaux, P. Felli, E. Cavalli, A. Sgrignani, J. Thumann, C. Koutsopoulos, O. Fuchs, B. C. Hoshida, Y. Hofmann, M. Vyberg, M. Viuff, B. M. Galsgaard, E. D. Elson, G. Toso, A. Meyer, M. Iacone, R. Schweighoffer, T. Teixeira, G. Moll, S. De Vito, C. Roskams, T. Davidson, I. Heide, D. Heikenwalder, M. Zeisel, M. B. Lupberger, J. Mailly, L. Schuster, C. Baumert, T. F.
  in Sci Transl Med (2022) Vol.14 ppeabj4221
  
• CEMIP (HYBID, KIAA1199): Structure, function and expression in health and disease
  Spataro, S. Guerra, C. Cavalli, A. Sgrignani, J. Sleeman, J. Poulain, L. Boland, A. Scapozza, L. Moll, S. Prunotto, M.
  in FEBS J (2022) Vol.290 pp3946-3962
  
• Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors
  Bettini, E. Stahl, S. M. De Martin, S. Mattarei, A. Sgrignani, J. Carignani, C. Nola, S. Locatelli, P. Pappagallo, M. Inturrisi, C. E. Bifari, F. Cavalli, A. Alimonti, A. Pani, L. Fava, M. Traversa, S. Folli, F. Manfredi, P. L.
  in Pharmaceuticals (Basel) (2022) Vol.15 pp
  
• Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity
  Fassi, E. M. A. Garofalo, M. Sgrignani, J. Dei Cas, M. Mori, M. Roda, G. Cavalli, A. Grazioso, G.
  in Int J Mol Sci (2022) Vol.23 pp
  
• Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction
  Sgrignani, J. Cecchinato, V. Fassi, E. M. A. D'Agostino, G. Garofalo, M. Danelon, G. Pedotti, M. Simonelli, L. Varani, L. Grazioso, G. Uguccioni, M. Cavalli, A.
  in J Med Chem (2021) Vol.64 pp13439-13450.
  
• Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
  Wright, M. B. Varona Santos, J. Kemmer, C. Maugeais, C. Carralot, J. P. Roever, S. Molina, J. Ducasa, G. M. Mitrofanova, A. Sloan, A. Ahmad, A. Pedigo, C. Ge, M. Pressly, J. Barisoni, L. Mendez, A. Sgrignani, J. Cavalli, A. Merscher, S. Prunotto, M. Fornoni, A.
  in Nat Commun (2021) Vol.12 pp4662
  
• EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer
  Zoma, M. Curti, L. Shinde, D. Albino, D. Mitra, A. Sgrignani, J. Mapelli, S. N. Sandrini, G. Civenni, G. Merulla, J. Chiorino, G. Kunderfranco, P. Cacciatore, A. Kokanovic, A. Rinaldi, A. Cavalli, A. Catapano, C. V. Carbone, G. M.
  in Nat Commun (2021) Vol.12 pp4147
  
• Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity
  Garofalo, M. Piccoli, L. Romeo, M. Barzago, M. M. Ravasio, S. Foglierini, M. Matkovic, M. Sgrignani, J. De Gasparo, R. Prunotto, M. Varani, L. Diomede, L. Michielin, O. Lanzavecchia, A. Cavalli, A.
  in Nature Communications (2021) Vol.12 pp3532
  
• Computational identification of a putative allosteric binding pocket in TMPRSS2
  Sgrignani, J. and Cavalli, A.
  in Front. Mol. Biosci. (2021) Vol.8 pp666626
  
• How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs
  Garofalo, M. Grazioso, G. Cavalli, A.
  in Molecules (2020) Vol.25 pppii: E1756
  
• Endoplasmic Reticulum and Lysosomal Quality Control of Four Nonsense Mutants of Iduronate 2-Sulfatase Linked to Hunter’s Syndrome
  Marazza, A. Galli, C. Fasana, E. Burda, P. Fassi, E. M. A. Baumgartner, M. Cavalli, A. Molinari, M.
  in DNA Cell Biol (2020) Vol.39 pp226-234
  
• Zinc(ii)-mediated diastereoselective Passerini reactions of biocatalytically desymmetrised renewable inputs
  Moni, L. Banfi, L. Cartagenova, D. Cavalli, A. Lambruschini, C. Martino, E. Orru, R. V. A. Ruijter, E. Saya, J. M. Sgrignani, J. Riva, R.
  in Organic Chemistry Frontiers (2019) Vol. pp
  
• Oxidation State Dependent Conformational Changes of HMGB1 Regulate the Formation of the CXCL12/HMGB1 Heterocomplex
  V. Fassi, E. M. A. Sgrignani, J. D'Agostino, V. Cecchinato, G. Garofalo, M. Grazioso, G. Uguccioni, M. Cavalli, A.
  in Comput Struct Biotechnol J (2019) Vol.17 pp886-894
  
• How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study
  Sgrignani, J. Chen, J. Alimonti, A. Cavalli, A.
  in Sci Rep (2018) Vol.8 pp14683
  
• Single or Multiple Access Channels to the CYP450s Active Site? an Answer from Free Energy Simulations of the Human Aromatase Enzyme
  Magistrato, A. Sgrignani, J. Krause, R. Cavalli, A.
  in J Phys Chem Lett (2017) Vol.8 pp2036-2042
  
• Enzymatic and Inhibition Mechanism of Human Aromatase (CYP19A1) Enzyme. A Computational Perspective from QM/MM and Classical Molecular Dynamics Simulations
  Sgrignani, J. Cavalli, A. Colombo, G.
  in Mini Rev Med Chem (2016) Vol.16 pp1112-24
  
• Allosteric Modulation of Alpha7 Nicotinic Receptors: Mechanistic Insight through Metadynamics and Essential Dynamics
  Grazioso, G. Sgrignani, J. Capelli, R. Dallanoce, C. De Amici, M. Cavalli, A.
  in J Chem Inf Model (2015) Vol.55 pp2528-39
  
• Molecular Determinants for Unphosphorylated STAT3 Dimerization Determined by Integrative Modeling
  Sgrignani, J. Olsson, S. Ekonomiuk, D. Krause, R. Catapano, C. V. Cavalli, A.
  in Biochemistry (2015) Vol.54 pp5489-501
  
• QM/MM MD Simulations on the Enzymatic Pathway of the Human Flap Endonuclease (hFEN1) Elucidating Common Cleavage Pathways to RNase H Enzymes
  Sgrignani, J. Magistrato, A.
  in ACS Catal. (2015) Vol.5 pp3864-3875
  
• Molecular Dynamics of Biomolecules through Direct Analysis of Dipolar Couplings
  Olsson, S. Ekonomiuk, D. Sgrignani, J. Cavalli, A.
  in J Am Chem Soc (2015) Vol.137 pp6270-8
  
• Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
  Chen, J. Guccini, I. Mitri, D. D. Revandkar, A. Sarti, M. Pasquini, E. Alajati, A. Pinton, S. Losa, M. Civenni, G. Catapano, C. V. Sgrignani, J. Cavalli, A. D'Antuono, R. Asara, J. M. Morandi, A. Chiarugi, P. Crotti, S. Agostini, M. Montopoli, M. Masgras, I. Rasola, A. Garcia-Escudero, R. Delaleu, N. Rinaldi, A. Bertoni, F. Bono, J. Carracedo, A. Alimonti, A.
  in Nat Genet (2015) Vol.50 pp219-228