Bellinzona 13.04.2021 – A paper from the González’s lab studies how to modify the innate immune response to improve the adaptive immunity against a potential HIV vaccine. To study this mechanism, we have employed the revolutionary intravital 2-photon imaging available at the IRB in Bellinzona. Using this technique, we have studied the role of a subtype of immune cells called neutrophils alpha and beta in the development of a proper immune response against a HIV vaccine candidate.
We have also applied different pharmacological approaches directed against these cells that aim at increasing the strength of the response against the vaccine. The current work will be important for the future development of an efficient HIV vaccine.
This work, directed by Dr. González, represents a collaborative effort between the Infection and Immunity group at the IRB, and the virology group directed from Prof. Mariano Esteban at the CNB in Madrid.
Illustration: Recruitment of alpha and beta neutrophils in the spleen after HIV vaccination
Article
Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection
Di Pilato M. , Palomino-Segura M. , Mejías-Pérez E. , Gómez C. E. , Rubio-Ponce A., D’Antuono R. , Pizzagalli D. U. , Pérez P. , Kfuri-Rubens R., Benguría A. , Dopazo A., Ballesteros I., Sorzano C. O. S., Hidalgo A., Esteban M. , Gonzàlez S.
NPJ Vaccines, 2021, 6:52.
