Human immune system variation and its origins early in life
Prof. Petter Brodin Professor/Specialist Physician at Karolinska Institutet, SE Wednesday, 17 Dicembre 2025 at 12:00 pm Bios+ Seminar Room
The Dangerous Effect of Tattoos on the Immune System
Are you aware that when you tattoo your skin, you are also tattooing your immune system? A groundbreaking study by a Swiss the research group led by Prof. Santiago F. González, published today in the prestigious journal Proceedings of the National Academy of Sciences (PNAS), raises new questions about the safety of tattoos. The study by […]
Immunemap, an open intravital microscopy atlas for systematic analysis of immune cell motility
A new study mapping immune cell motility across organs and conditions is published in EMBO Journal. This work is a collaboration between the González Group at the Institute for Research in Biomedicine (IRB, an Institute affiliated with USI Università della Svizzera italiana) and the Pizzagalli and Krause Group at the Euler Institute and supported by […]
Loss of the anti-recombinase FIGNL1 restores survival of BRCA2-deficient cells by rescuing their DNA repair capacity.
(from left to right) Dr. Ananya Acharya, Stefan Braunshier and Safa Nasrin, co-authors of the publication. A collaborative paper published in Science by the team led by Prof. Chaudhuri at the Erasmus MC Cancer Center (Netherlands) and Prof. Cejka at the IRB in Bellinzona, reveals that the anti-recombinase FIGNL1 inhibits DNA repair in BRCA2-deficient cells […]
Clearance of disease-causing misfolded proteins from our cells: a matter of contacts
In an article published in Autophagy Reports, Prof. Molinari’s Laboratory shows how our cells remove toxic proteins by promoting the formation of contact sites between the biosynthetic compartment (the endoplasmic reticulum) and the degradative compartments (the endolysosomes). Bellinzona – November 3rd, 2025 – DNA mutations that occur spontaneously or can be inherited, lead to the […]
Mechanistic answer to how CAG expansion arise in Huntington’s disease
Published in Nature Communications, the work from the Cejka laboratory reveals how MutSβ-MutLγ-driven trinucleotide expansion arise in neural cells and how FAN1 safeguards the genome. This mechanism clarifies Huntington’s disease biology and points to therapeutic targets. Huntington’s disease is driven by the gradual expansion of CAG repeats in the HTT gene in brain cells. How […]
Dissecting and rewiring antitumor T cell immunity in human cancer tissues
Prof. Daniela Thommen Netherlands Cancer Institute & Oncode Institute– NL Tuesday, 25 November 2025 at 12:00 pm Bios+ Seminar Room
Targeting FOXA1 and FOXA2 disrupts the oncogenic output program in prostate cancer
Prostate cancer is a prevalent and lethal cancer. Research groups at the IOR (Theurillat) and IRB (Cavalli) publish in Cell Reports the first-in-class inhibitors targeting FOXA1 and FOXA2, two key transcription factors driving prostate cancer progression thought to be undruggable thus far. Activation of the androgen receptor (AR) is the key lineage-specific oncogenic pathway and […]
A new study published by the Monticelli lab characterizes an immunoregulatory receptor
Image Caption: FCRL3 expression is sufficient to modulate T cell responses through the engagement with negative regulators of signaling (image by Elena Foli). A new study is published in the Journal of Experimental Medicine by the Molecular Immunology lab. This study characterizes the FCRL3 receptor as an immunoregulatory molecule that modulates human T cell responses. […]
Conference on immunotherapy for infectious diseases 2025
The 4th edition of the ITID (Immunotherapy for Infectious Diseases) Conference successfully took place in Bellinzona, Switzerland, from October 1 to 3, 2025, at BIOS+ (Via Francesco Chiesa 5). The event, organized with the support of the Institute for Research in Biomedicine (IRB), an Istitute affiliated to Università della Svizzera italiana (USI), brought together leading […]
