Archives

Clearance of disease-causing misfolded proteins from our cells: a matter of contacts

In an article published in Autophagy Reports, Prof. Molinari’s Laboratory shows how our cells remove toxic proteins by promoting the formation of contact sites between the biosynthetic compartment (the endoplasmic reticulum) and the degradative compartments (the endolysosomes). Bellinzona – November 3rd, 2025 – DNA mutations that occur spontaneously or can be inherited, lead to the […]

Mechanistic answer to how CAG expansion arise in Huntington’s disease

Published in Nature Communications, the work from the Cejka laboratory reveals how MutSβ-MutLγ-driven trinucleotide expansion arise in neural cells and how FAN1 safeguards the genome. This mechanism clarifies Huntington’s disease biology and points to therapeutic targets. Huntington’s disease is driven by the gradual expansion of CAG repeats in the HTT gene in brain cells. How […]

Targeting FOXA1 and FOXA2 disrupts the oncogenic output program in prostate cancer

Prostate cancer is a prevalent and lethal cancer. Research groups at the IOR (Theurillat) and IRB (Cavalli) publish in Cell Reports the first-in-class inhibitors targeting FOXA1 and FOXA2, two key transcription factors driving prostate cancer progression thought to be undruggable thus far. Activation of the androgen receptor (AR) is the key lineage-specific oncogenic pathway and […]

A new study published by the Monticelli lab characterizes an immunoregulatory receptor

Image Caption: FCRL3 expression is sufficient to modulate T cell responses through the engagement with negative regulators of signaling (image by Elena Foli). A new study is published in the Journal of Experimental Medicine by the Molecular Immunology lab. This study characterizes the FCRL3 receptor as an immunoregulatory molecule that modulates human T cell responses. […]

Conference on immunotherapy for infectious diseases 2025

The 4th edition of the ITID (Immunotherapy for Infectious Diseases) Conference successfully took place in Bellinzona, Switzerland, from October 1 to 3, 2025, at BIOS+ (Via Francesco Chiesa 5). The event, organized with the support of the Institute for Research in Biomedicine (IRB), an Istitute affiliated to Università della Svizzera italiana (USI), brought together leading […]