Publications - IRB USI

Publications

ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome
Clarke, T. L. Cho, H. M. Ceppi, I. Gao, B. Yadav, T. Silveira, G. G. Boon, R. Martinez-Pastor, B. Amoh, N. Y. A. Machin, B. Bernasocchi, T. Ashfaq, D. Mendez, J. Kamaliyan, Z. Del Rio Pantoja, J. Rogines, G. S. Crowley, B. T. McGinn, D. E. Giunta, V. Tran, O. Zackai, E. H. Lan, L. Zou, L. Emanuel, B. S. McDonald-McGinn, D. M. Cejka, P. Mostoslavsky, R.
in Nat Cell Biol (2025) Vol. pp
An integrated proteomic portrait of prostate cancer progression
Zhang, J. Rivera, K. D. Bossi, D. Gianfanti, F. Nicastri, S. Gomes, D. Matkovic, M. Coazzoli, M. Mosole, S. Costanzo, F. Vallerga, A. Ceserani, V. Cavalli, M. Virshup, M. Burt, R. A. Bolis, M. Ruthishauser, D. Stathis, A. Moch, H. Bubendorf, L. Cavalli, A. Corey, E. Wang, Y. Mani, D. R. Carr, S. A. Udeshi, N. Theurillat, J. P.
in Cell Rep (2025) Vol.44 pp115828
FYCO1 Peptide Analogs: Design and Characterization of Autophagy Inhibitors as Co-Adjuvants in Taxane Chemotherapy of Prostate Cancer
Fassi, E. M. A. Moretti, R. M. Montagnani Marelli, M. Garofalo, M. Gori, A. Pesce, C. Albani, M. Milano, E. G. Sgrignani, J. Cavalli, A. Grazioso, G.
in Int J Mol Sci (2025) Vol.26 pp
Human LY9 governs CD4(+) T cell IFN-gamma immunity to Mycobacterium tuberculosis
Ogishi, M. Puchan, J. Yang, R. Arias, A. A. Han, J. E. Nguyen, T. Gutierrez-Cozar, R. Conil, C. Seeleuthner, Y. Rinchai, D. Zhang, P. Ponsin, K. Chaldebas, M. Feng, Y. Neehus, A. L. Delmonte, O. M. Khan, T. Landegren, N. Eriksson, D. Bohlen, J. Peel, J. N. Fagniez, I. Pelham, S. J. Lei, W. T. Chrabieh, M. Laine, C. Ouair, H. Benhsaien, I. Abid, A. Abderrhamani Ghorfi, I. Souhi, H. Ouazzani, H. Aniss, R. Riminton, D. S. Kampe, O. Turvey, S. E. Marr, N. Notarangelo, L. D. Hatipoglu, N. Bousfiha, A. Ozcelik, T. El Baghdadi, J. Cobat, A. Ma, C. S. Abel, L. Puel, A. Bustamante, J. Engel, P. Gros, P. Tangye, S. G. Sallusto, F. Boisson-Dupuis, S. Casanova, J. L.
in Sci Immunol (2025) Vol.10 ppeads7377
Identification of cross-stage, cross-species malaria CD8+ T cell antigens
Junqueira, C. Barbosa, Crrb de Lacerda, L. Bettencourt, P. Morrow, D. Pereira, D. Aleshnick, M. Mitchell, J. Zhao, Z. Castro, G. Almeida, G. Gomes, C. Nicastri, A. Schrimpf, M. R. Gilbride, R. Schell, J. Kirtley, P. K. Antonelli, L. Gaiha, G. Hansen, S. Fruh, K. Lieberman, J. Gazzinelli, R. Ternette, N. Wilder, B. Hill, A. Costa, C.
in Res Sq (2025) Vol. pp
A novel allosteric GCase modulator prevents Tau accumulation in GBA1(WT) and GBA1(L444P/L444P) cellular models
Ciccaldo, M. Perez-Carmona, N. Piovesana, E. Cano-Crespo, S. Ruano, A. Delgado, A. Fregno, I. Calvo-Flores Guzman, B. Bellotto, M. Molinari, M. Taylor, J. Papin, S. Garcia-Collazo, A. M. Paganetti, P.
in Sci Rep (2025) Vol.15 pp17646
Allosteric Modulation of GCase Enhances Lysosomal Activity and Reduces ER Stress in GCase-Related Disorders
Fregno, I. Pérez-Carmona, N. Rudinskiy, M. Soldà, T. Bergmann, T. J. Ruano, A. Delgado, A. Cubero, E. Bellotto, M. García-Collazo, A. M. Molinari, M.
in Int. J. Mol. Sci. (2025) Vol.26 pp4392
ER-to-lysosome-associated degradation
Molinari, M.
in Curr Biol (2025) Vol.35 ppR320-R322
EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA
Roy, M. Sanchez, A. Guerois, R. Senoussi, I. Cerana, A. Sgrignani, J. Cavalli, A. Rinaldi, A. Cejka, P.
in Nat Commun (2025) Vol.16 pp4141
A Potent Nonapeptide Inhibitor for the CXCL12/HMGB1 heterocomplex: A Computational and Experimental Approach
Fassi, E., Pirani, E. Cecchinato, V. Cavalli, A. Roda, G. Uguccioni, M., Sgrignani, J., Grazioso, G.
in Comput. Struct. Biotechnol. J. (2025) Vol. pp
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
Jobin, K. Seetharama, D. Ruttger, L. Fenton, C. Kharybina, E. Wirsching, A. Huang, A. Knopper, K. Kaisho, T. Busch, D. H. Vaeth, M. Saliba, A. E. Graw, F. Pulfer, A. Gonzalez, S. F. Zehn, D. Liang, Y. Ugur, M. Gasteiger, G. Kastenmuller, W.
in Science (2025) Vol.388 ppeadq1405
The PIN1-p38-CtIP signalling axis protects stalled replication forks from deleterious degradation
Vivalda, F. Gatti, M. Manfredi, L. Dogan, H. Porro, A. Collotta, G. Ceppi, I. von Aesch, C. van Ackeren, V. Wild, S. Steger, M. Canovas, B. Cubillos-Rojas, M. Riera, A. Cejka, P. Nebreda, A. R. Dibitetto, D. Rottenberg, S. Sartori, A. A.
in Nucleic Acids Res (2025) Vol.53 pp
An in vivo microscopy dataset for the characterization of leukocyte death
Pulfer, A. Pizzagalli, D. U. Segura, M. P. Germic, N. Virgilio, T. Di Pilato, M. Carrillo Barbera, P. Palladino, E. Antonello, P. Thelen, M. Simon, H. U. Krause, R. Gonzalez, S. F.
in Sci Data (2025) Vol.12 pp593
Comprehensive interrogation of synthetic lethality in the DNA damage response
Fielden, J. Siegner, S. M. Gallagher, D. N. Schroder, M. S. Dello Stritto, M. R. Lam, S. Kobel, L. Schlapansky, M. F. Jackson, S. P. Cejka, P. Jost, M. Corn, J. E.
in Nature (2025) Vol.640 pp1093-1102
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
Lai, P. Liu, L. Bancaro, N. Troiani, M. Cali, B. Li, Y. Chen, J. Singh, P. K. Arzola, R. A. Attanasio, G. Pernigoni, N. Pasquini, E. Mosole, S. Rinaldi, A. Sgrignani, J. Qiu, S. Song, P. Desbats, M. A. Angel, A. R. Mestre, R. P. Cavalli, A. Barile, L. de Bono, J. Alimonti, A.
in Immunity (2025) Vol.58 pp811-825 e7
Mechanisms and regulation of DNA end resection in the maintenance of genome stability
Ceccaldi, R. Cejka, P.
in Nat Rev Mol Cell Biol (2025) Vol. pp
MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage
Seppa, I. M. Ceppi, I. Tennakoon, M. Reginato, G. Jackson, J. Rouault, C. D. Agashe, S. Sviderskiy, V. O. Limbu, M. Lantelme, E. Meroni, A. Braunshier, S. Borrello, D. Verma, P. Cejka, P. Vindigni, A.
in Genes Dev (2025) Vol.39 pp582-602.
New Synthesis and Pharmacological Evaluation of Enantiomerically Pure (R)- and (S)-Methadone Metabolites as N-Methyl-d-aspartate Receptor Antagonists
Banzato, M. Furlan, A. Locatelli, P. Sgrignani, J. Ongaro, A. Dolmella, A. De Martin, S. Comai, S. Cavalli, A. Inturrisi, C. Bettini, E. Manfredi, P. L. Mattarei, A.
in J Med Chem (2025) Vol.68 pp5455-5470
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
Szpakowska, M. Legler, D. F. Offermanns, S. Sozzani, S. Rot, A. Thelen, M. Chevigne, A.
in Nat Rev Immunol (2025) Vol. pp
Clonal analysis of SepSecS-specific B and T cells in autoimmune hepatitis
Kramer, M. Mele, F. Jovic, S. Fernandez, B. M. Jarrossay, D. Low, J. S. Sokollik, C. Filipowicz Sinnreich, M. Ferrari-Lacraz, S. Mieli-Vergani, G. Vergani, D. Lanzavecchia, A. Cassotta, A. Terziroli Beretta-Piccoli, B. Sallusto, F.
in J Clin Invest (2025) Vol.135 pp
Dual Activation-Induced Marker Combinations Efficiently Identify and Discern Antigen-Specific and Bystander-Activated Human CD4(+) T Cells
Ceraolo, M. G. Leccese, M. Cassotta, A. Triolo, S. Bombaci, M. Coluccio, E. Prati, D. Ungaro, R. Abrignani, S. Bandera, A. Sallusto, F. Lanzavecchia, A. Notarbartolo, S.
in Eur J Immunol (2024) Vol.55 ppe202451404
Ultrapotent IgA dimeric antibodies neutralize emerging Omicron variants
Zuo, F. Cao, Y. Sun, R. Wang, Q. Simonelli, L. Du, L. Bertoglio, F. Schubert, M. Guerra, C. Cavalli, A. Hust, M. Robbiani, D. F. Varani, L. Abolhassani, H. Xie, X. S. Hammarstrom, L. Marcotte, H. Pan-Hammarstrom, Q.
in J Virol (2024) Vol. ppe0174024
Discovery of a pan anti-SARS-CoV-2 monoclonal antibody with highly efficient infected cell killing capacity for novel immunotherapeutic approaches
Moussa, D. A. Vazquez, M. Chable-Bessia, C. Roux-Portalez, V. Tamagnini, E. Pedotti, M. Simonelli, L. Ngo, G. Souchard, M. Lyonnais, S. Chentouf, M. Gros, N. Marsile-Medun, S. Dinter, H. Pugniere, M. Martineau, P. Varani, L. Juan, M. Calderon, H. Naranjo-Gomez, M. Pelegrin, M.
in Emerg Microbes Infect (2024) Vol. pp2432345
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease
Tejedor Vaquero, S. Neuman, H. Comerma, L. Marcos-Fa, X. Corral-Vazquez, C. Uzzan, M. Pybus, M. Segura-Garzon, D. Guerra, Jo. Perruzza, L. Tacho-Pinot, R. Sintes, J. Rosenstein, A. Grasset, E. K. Iglesias, M. Gonzalez Farre, M. Lop, J. Patriaca-Amiano, M. E. Larrubia-Loring, M. Santiago-Diaz, P. Perera-Bel, J. Berenguer-Molins, P. Martinez Gallo, M. Martin-Nalda, A. Varela, E. Garrido-Pontnou, M. Grassi, F. Guarner, F. Mehandru, S. Marquez-Mosquera, L. Mehr, R. Cerutti, A. Magri, G.
in J Exp Med (2024) Vol.221 ppe20230079
Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis
Pietrasanta, C. Carlosama, C. Lizier, M. Fornasa, G. Jost, T. R. Carloni, S. Giugliano, S. Silvestri, A. Brescia, P. De Ponte Conti, B. Braga, D. Mihula, M. Morosi, L. Bernardinello, A. Ronchi, A. Martano, G. Mosca, F. Penna, G. Grassi, F. Pugni, L. Rescigno, M.
in Cell Host Microbe (2024) Vol.32 pp2178-2194.e6.

Istituto di Ricerca in Biomedicina

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