on March 15, 2017
The inflammatory process initiated in the lymph node after vaccine administration is crucial to develop a protective response against the pathogen. In this work, we describe the mechanism by which one of the most relevant cells involved in the inflammatory process, the lymph node macrophages, initiate this response. These cells die quickly after vaccine administration, and their death promote the release of different molecules, which act as an alarm signal and activate other immune cells. The description of this pathway will open new possibilities to improve vaccine efficiency.
3D reconstruction of a whole popliteal lymph node by 2-photon microscopy; in the picture are showed the Subcapsular Sinus Macrophages (yellow), Medullary macrophages (red), B cells follicles (blue) and transgenic CX3CR1 (green).
Article
Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node
N. Chatziandreou, Y. Farsakoglu, M. Palomino-Segura, R. D’Antuono, D. U. Pizzagalli, F. Sallusto, V. Lukacs-Kornek, M. Uguccioni, D. Corti, S. J. Turley, A. Lanzavecchia, M. C. Carroll, S. F. Gonzalez
in Cell Rep (2017) vol. 18 pp2427-2440
