Guarda Greta, PhD

Publications

• A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers
  Spriano, F. Sartori, G. Sgrignani, J. Barnabei, L. Arribas, A. J. Guala, M. Del Amor, A. M. C. Tomasso, M. R. Tarantelli, C. Cascione, L. Golino, G. Riveiro, M. E. Bortolozzi, R. Lupia, A. Paduano, F. Huguet, S. Rezai, K. Rinaldi, A. Margheriti, F. Ventura, P. Guarda, G. Costa, G. Rocca, R. Furlan, A. Verdonk, L. M. Innocenti, P. Martin, N. I. Viola, G. Driessen, C. Zucca, E. Stathis, A. Gahtory, D. Van den Nieuwboer, M. Bornhauser, B. Alcaro, S. Trapasso, F. Cristobal, S. Padrick, S. B. Pazzi, N. Cavalli, F. Cavalli, A. Gaudio, E. Bertoni, F.
  in Haematologica (2024) Vol.109 pp3602-3614
  
• NLRC5: back to innate immunity
  Guerra, J. Guarda, G.
  in Trends Immunol (2024) Vol.45 pp571-573
  
• A Menage a trois: NLRC5, immunity, and metabolism
  Brunschwiler, F. Nakka, S. Guerra, J. Guarda, G.
  in Front Immunol (2024) Vol.15 pp1426620
  
• A first-in-class Wiskott-Aldrich syndrome protein activator with anti-tumor activity in hematologic cancers
  Spriano, F. Sartori, G. Sgrignani, J. Barnabei, L. Arribas, A. J. Guala, M. Del Amor, A. M. C. Tomasso, M. R. Tarantelli, C. Cascione, L. Golino, G. Riveiro, M. E. Bortolozzi, R. Lupia, A. Paduano, F. Huguet, S. Rezai, K. Rinaldi, A. Margheriti, F. Ventura, P. Guarda, G. Costa, G. Rocca, R. Furlan, A. Verdonk, L. M. Innocenti, P. Martin, N. I. Viola, G. Driessen, C. Zucca, E. Stathis, A. Gahtory, D. Van den Nieuwboer, M. Bornhauser, B. Alcaro, S. Trapasso, F. Cristobal, S. Padrick, S. B. Pazzi, N. Cavalli, F. Cavalli, A. Gaudio, E. Bertoni, F.
  in Haematologica (2024) Vol. pp
  
• Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease
  Dennison, T. W. Edgar, R. D. Payne, F. Nayak, K. M. Ross, A. D. B. Cenier, A. Glemas, C. Giachero, F. Foster, A. R. Harris, R. Kraiczy, J. Salvestrini, C. Stavrou, G. Torrente, F. Brook, K. Trayers, C. Elmentaite, R. Youssef, G. Tel, B. Winton, D. J. Skoufou-Papoutsaki, N. Adler, S. Bufler, P. Azabdaftari, A. Jenke, A. G, N. Thomas, N. Miele, E. Al-Mohammad, A. Guarda, G. Kugathasan, S. Venkateswaran, S. Clatworthy, M. R. Castro-Dopico, T. Suchanek, O. Strisciuglio, C. Gasparetto, M. Lee, S. Xu, X. Bello, E. Han, N. Zerbino, D. R. Teichmann, S. A. Nys, J. Heuschkel, R. Perrone, F. Zilbauer, M.
  in Gut (2024) Vol.73 pp1464-1477
  
• The bacterial lysate OM-85 engages Toll-like receptors 2 and 4 triggering an immunomodulatory gene signature in human myeloid cells
  Khameneh, H. J. Bolis, M. Ventura, P. Cassanmagnago, G. A. Fischer, B. A. Zenobi, A. Guerra, J. Buzzago, I. Bernasconi, M. Zaman, G. J. R. Rinaldi, A. Moro, S. G. Sallusto, F. Baulier, E. Pasquali, C. Guarda, G.
  in Mucosal Immunol (2024) Vol.17 pp346-358.
  
• Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
  Colucci, M. Zumerle, S. Bressan, S. Gianfanti, F. Troiani, M. Valdata, A. D'Ambrosio, M. Pasquini, E. Varesi, A. Cogo, F. Mosole, S. Dongilli, C. Desbats, M. A. Contu, L. Revankdar, A. Chen, J. Kalathur, M. Perciato, M. L. Basilotta, R. Endre, L. Schauer, S. Othman, A. Guccini, I. Saponaro, M. Maraccani, L. Bancaro, N. Lai, P. Liu, L. Pernigoni, N. Mele, F. Merler, S. Trotman, L. C. Guarda, G. Cali, B. Montopoli, M. Alimonti, A.
  in Cancer Cell (2024) Vol. pp
  
• Myc controls NK cell development, IL-15-driven expansion, and translational machinery
  Khameneh, H. J. Fonta, N. Zenobi, A. Niogret, C. Ventura, P. Guerra, C. Kwee, I. Rinaldi, A. Pecoraro, M. Geiger, R. Cavalli, A. Bertoni, F. Vivier, E. Trumpp, A. Guarda, G.
  in Life Sci Alliance (2023) Vol.6 ppe202302069.
  
• SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency
  Schmied, L. Luu, T. T. Sondergaard, J. N. Hald, S. H. Meinke, S. Mohammad, D. K. Singh, S. B. Mayer, C. Perinetti Casoni, G. Chrobok, M. Schlums, H. Rota, G. Truong, H. M. Westerberg, L. S. Guarda, G. Alici, E. Wagner, A. K. Kadri, N. Bryceson, Y. T. Saeed, M. B. Hoglund, P.
  in Sci Signal (2023) Vol.16 ppeabq0752
  
• Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses
  Ventura, P. M. O. Gakovic, M. Fischer, B. A. Spinelli, L. Rota, G. Pathak, S. Khameneh, H. J. Zenobi, A. Thomson, S. Birchmeier, W. Cantrell, D. A. Guarda, G.
  in EMBO Rep (2022) Vol. ppe55399
  
• FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
  Gonzalez-Loyola, A. Bovay, E. Kim, J. Lozano, T. W. Sabine, A. Renevey, F. Arroz-Madeira, S. Rapin, A. Wypych, T. P. Rota, G. Durot, S. Velin, D. Marsland, B. Guarda, G. Delorenzi, M. Zamboni, N. Luther, S. A. Petrova, T. V.
  in Sci Adv (2021) Vol.7 ppeabf4335
  
• NLRC5 promotes transcription of BTN3A1-3 genes and Vγ9Vδ2 T cell-mediated killing
  Dang, A.T., Strietz, J., Zenobi, A., Khameneh, H.J., Brandl, S.M., Lozza, L., Conradt, G., Kaufmann, S.H.E., Reith, W., Kwee, I., Minguet, S., Chelbi, S.T., Guarda, G.
  in iScience (2020) Vol.24 pp101900
  
• Regulatory Factor X 7 and its Potential Link to Lymphoid Cancers
  Fischer, B. A. Chelbi, S. T. Guarda, G.
  in Trends in Cancer (2019) Vol.6 pp
  
• SHP-2 in Lymphocytes’ Cytokine and Inhibitory Receptor Signaling
  Niogret, C. Birchmeier, W. Guarda, G.
  in Front Immunol (2019) Vol.10 pp2468
  
• Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
  Niogret, C. Miah, S. M. S. Rota, G. Wang, H. Held, W. Birchmeier, W. Sexl, V. Yang, W. Vivier, E. Ho, P. C. Brossay, L. Guarda, G.
  in Nat Commun (2019) Vol.10 pp1444
  
• The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
  Castro, W. Chelbi, S. T. Niogret, C. Welten, S. P. M. Osterheld, K. Wang, H. Rota, G. Morgado, L. Vivier, E. Raeber, M. E. Boyman, O. Delorenzi, M. Barras, D. Ho, P. C. Oxenius, A. Guarda, G.
  in Nat Immunol (2018) Vol.19 pp809-820
  
• Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
  Rota, G. Niogret, C. Dang, A. T. Fonta, N. P. Alfei, F. Morgado, L. Zehn, D. Birchmeier, W. Vivier, E. Guarda, G.
  in Cell Rep (2018) Vol.23 pp39-49
  
• The regulatory network behind MHC class I expression
  Jongsma, M. L. M. Guarda, G. Spaapen, R. M.
  in Mol Immunol (2017) Vol. pp
  
• OM-85 is an immunomodulator of interferon-beta production and inflammasome activity
  Dang, A. T. Pasquali, C. Ludigs, K.
  in Sci Rep (2017) Vol.7 pp43844
  
• Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5
  Chelbi, S. T. Dang, A. T. Guarda, G.
  in Adv Immunol (2017) Vol.133 pp89-119
  * S. T. Chelbi and A. T. Dang equally contributed to this work.
• NLRC5, a promising new entry in tumor immunology
  Chelbi, S. T. Guarda, G.
  in J Immunother Cancer (2016) Vol.4 pp39
  
• T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels
  Rota, G. Ludigs, K. Siegert, S. Morgado, L. Reith, W. De Gassart, A. Guarda, G.
  in J Immunol (2016) Vol.196 pp2939-46
  
• NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
  Ludigs, K. Jandus, C. Utzschneider, D. T. Bessoles, S. Dang, A. T. Rota, G. Castro, W. Zehn, D. Vivier, E. Held, W. Romero, P. Guarda, G.
  in Nat Commun (2016) Vol.7 pp10554
  
• NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module
  Ludigs, K. Seguin-Estevez, Q. Lemeille, S. Rota, G. Chelbi, S. Mattmann, C. MacDonald, H. R. Reith, W. Guarda, G.
  in PLoS Genet (2015) Vol.11 ppe1005088
  * W. Reith and G. Guarda share the senior authorship and are corresponding authors.
• NLRC5, at the Heart of Antigen Presentation
  Neerincx, A. Castro, W. Guarda, G.
  in Front Immunol (2013) Vol.4 pp397
  *G. Guarda and T. Kufer are corresponding authors.
• The Nlrp3 inflammasome regulates acute graft-versus-host disease
  Jankovic, D. Ganesan, J. Bscheider, M. Weber, F. C. Guarda, G. Follo, M. Pfeifer, D. Tardivel, A. Ludigs, K. Bouazzaoui, A. Kerl, K. Fischer, J. C. Haas, T. Schmitt-Graff, A. Manoharan, A. Muller, L. Finke, J. Martin, S. F. Gorka, O. Peschel, C. Ruland, J. Idzko, M. Duyster, J. Holler, E. French, L. E. Poeck, H. Contassot, E. Zeiser, R.
  in J Exp Med (2013) Vol.210 pp1899-910
  
• Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation
  Yan, Y. Jiang, W. Spinetti, T. Castillo, R. Bourquin, C. Guarda, G. Tian, Z. Tschopp, J. Zhou, R.
  in Immunity (2013) Vol.38 pp1154-63
  
• Innate receptors for adaptive immunity
  Michallet, M. C. Rota, G. Maslowski, K.
  in Curr Opin Microbiol (2013) Vol.16 pp296-302
  
• Innate and adaptive effects of inflammasomes on T cell responses
  Dostert, C. Ludigs, K. Guarda, G.
  in Curr Opin Immunol (2013) Vol.25 pp359-65
  
• Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1beta production
  Kolly, L. Busso, N. von Scheven-Gete, A. Moix, I. Holzinger, D. Simon, G. Ives, A. Guarda, G. So, A. Morris, M. A. Hofer, M.
  in J Allergy Clin Immunol (2012) Vol.131 pp1635-43
  
• Type I IFN-mediated regulation of IL-1 production in inflammatory disorders
  Ludigs, K. Parfenov, V. Du Pasquier, R. A.
  in Cell Mol Life Sci (2012) Vol.69 pp3395-418
  
• Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1
  Gross, O. Yazdi, A. S. Thomas, C. J. Heinz, L. X. Guarda, G. Quadroni, M. Drexler, S. K. Tschopp, J.
  in Immunity (2012) Vol.36 pp388-400
  
• NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells
  Staehli, F. Ludigs, K. Heinz, L. X. Ferrero, I. Braun, M. Schroder, K. Rebsamen, M. Tardivel, A. Mattmann, C. MacDonald, H. R. Romero, P. Reith, W. Guarda, G. Tschopp, J.
  in J Immunol (2012) Vol.188 pp3820-8
  *G. Guarda and J. Tschopp share the senior autorship, G. Guarda is the corresponding author.
• Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
  Vince, J. E. Wong, W. W. Gentle, I. Allam, R. O'Reilly, L. Mason, K. Gross, O. Ma, S. Guarda, G. Anderton, H. Castillo, R. Hacker, G. Silke, J. Tschopp, J.
  in Immunity (2012) Vol.36 pp215-27
  
• NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8(+) T cells
  Kupz, A. Guarda, G. Gebhardt, T. Short, K. R. Diavatopoulos, D. A. Wijburg, O. L. Cao, H. Waithman, J. C. Chen, W. Fernandez-Ruiz, D. Whitney, P. G. Heath, W. R. Curtiss, R., 3rd Tschopp, J. Strugnell, R. A. Bedoui, S.
  in Nat Immunol (2012) Vol.13 pp162-9
  
• The inflammasome: an integrated view
  Gross, O. Thomas, C. J. Guarda, G.
  in Immunol Rev (2011) Vol.243 pp136-51
  *G. Guarda and J. Tschopp share the senior autorship and G. Guarda is the corresponding author.
• Acute gout: The inflammasome.
  Guarda, G. Yazdi, A.S. D'Ombrain, M.C.
  in Current Rheumatology Reviews (2011) Vol.7 pp132-140
  *G. Guarda and A. S. Yazdi equally contributed to this work.
• NLRX1/NOD5 deficiency does not affect MAVS signalling
  Rebsamen, M. Vazquez, J. Tardivel, A. Curran, J. Tschopp, J.
  in Cell Death Differ (2011) Vol.18 pp1387
  
• Type I interferon inhibits interleukin-1 production and inflammasome activation
  Guarda, G. Braun, M. Staehli, F. Mattmann, C. Forster, I. Farlik, M. Decker, T. Du Pasquier, R. A. Romero, P. Tschopp, J.
  in Immunity (2011) Vol.34 pp213-23
  *G. Guarda and M. Braun contributed equally to this work.
• Differential expression of NLRP3 among hematopoietic cells
  Guarda, G. Zenger, M. Yazdi, A. S. Ferrero, I. Menu, P. Tardivel, A. Mattmann, C. Tschopp, J.
  in J Immunol (2011) Vol.186 pp2529-34
  *G. Guarda and M. Zenger contributed equally to this work.
• Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta
  Yazdi, A. S. Guarda, G. Riteau, N. Tardivel, A. Couillin, I. Tschopp, J.
  in Proc Natl Acad Sci U S A (2010) Vol.107 pp19449-54
  
• Regulation of inflammasome activity
  Guarda, G. So, A.
  in Immunology (2010) Vol.130 pp329-36
  
• Inflammatory caspases in innate immunity and inflammation
  Yazdi, A. S. Guarda, G. D'Ombrain, M. C.
  in J Innate Immun (2010) Vol.2 pp228-37
  
• Malarial hemozoin is a Nalp3 inflammasome activating danger signal
  Dostert, C. Guarda, G. Romero, J. F. Gross, O. Tardivel, A. Suva, M. L. Stehle, J. C. Kopf, M. Stamenkovic, I. Corradin, G. Tschopp, J.
  in PLoS One (2009) Vol.4 ppe6510
  *G. Guarda and J. F. Romero contibuted equally to this work.
• T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
  Guarda, G. Dostert, C. Staehli, F. Castillo, R. Tardivel, A. Schneider, P. Tschopp, J.
  in Nature (2009) Vol.460 pp269-73
  
• CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
  Martin-Fontecha, A. Baumjohann, D. Guarda, G. Hons, M. Lanzavecchia, A. Sallusto, F.
  in J Exp Med (2008) Vol.205 pp2561-74
  *Alfonso Martín-Fontecha and Federica Sallusto are co-corresponding authors.
• Activated Lymph Nodes Recruit Blood Borne NK Cells and Effector T Cells:Implications for Adaptive T Cell Responses
  Martin-Fontecha, A. Guarda, G. Lanzavecchia, A.
  in Current Immunology Reviews (2008) Vol.4 pp20-27
  
• The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
  Lozza, L. Rivino, L. Guarda, G. Rinaldi, A. Bertoni, F. Sallusto, F. Lanzavecchia, A. Geginat, J.
  in Eur J Immunol (2007) Vol.38 pp30-9
  
• L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
  Guarda, G. Hons, M. Soriano, S. F. Polley, R. Martin-Fontecha, A. Stein, J. V. Germain, R. N. Lanzavecchia, A. Sallusto, F.
  in Nat Immunol (2007) Vol.8 pp743-52
  
• Encoded Self-Assembling Chemical Libraries
  Melkko, S. Sobek, J. Guarda, G. Dumelin, C. E. Neri, D.
  in CHIMIA (2005) Vol.59 pp798-802