Pedotti Mattia, PhD

Publications

• Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages
  Marcotte, H. Cao, Y. Zuo, F. Simonelli, L. Sammartino, J. C. Pedotti, M. Sun, R. Cassaniti, I. Hagbom, M. Piralla, A. Yang, J. Du, L. Percivalle, E. Bertoglio, F. Schubert, M. Abolhassani, H. Sherina, N. Guerra, C. Borte, S. Rezaei, N. Kumagai-Braesch, M. Xue, Y. Su, C. Yan, Q. He, P. Gronwall, C. Klareskog, L. Calzolai, L. Cavalli, A. Wang, Q. Robbiani, D. F. Hust, M. Shi, Z. Feng, L. Svensson, L. Chen, L. Bao, L. Baldanti, F. Xiao, J. Qin, C. Hammarstrom, L. Yang, X. Varani, L. Xie, X. S. Pan-Hammarstrom, Q.
  in Proc Natl Acad Sci U S A (2024) Vol.121 ppe2315354120
  
• Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer
  Guerrini, G. Mehn, D. Fumagalli, F. Gioria, S. Pedotti, M. Simonelli, L. Bianchini, F. Robbiani, D. F. Varani, L. Calzolai, L.
  in Int J Mol Sci (2023) Vol.24 pp
  
• Adapting Neutralizing Antibodies to Viral Variants by Structure-Guided Affinity Maturation Using Phage Display Technology
  Peissert, F. Pedotti, M. Corbellari, R. Simonelli, L. De Gasparo, R. Tamagnini, E. Plüss, L. Elsayed, A. Matasci, M. De Luca, R. Cassaniti, I. Sammartino, J. C. Piralla, A. Baldanti, F. Neri, D. Varani, L.
  in Global Challenges (2023) Vol. pp
  
• Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
  Muri, J. Cecchinato, V. Cavalli, A. Shanbhag, A. A. Matkovic, M. Biggiogero, M. Maida, P. A. Moritz, J. Toscano, C. Ghovehoud, E. Furlan, R. Barbic, F. Voza, A. De Nadai, G. Cervia, C. Zurbuchen, Y. Taeschler, P. Murray, L. A. Danelon-Sargenti, G. Moro, S. Gong, T. Piffaretti, P. Bianchini, F. Crivelli, V. Podesvova, L. Pedotti, M. Jarrossay, D. Sgrignani, J. Thelen, S. Uhr, M. Bernasconi, E. Rauch, A. Manzo, A. Ciurea, A. Rocchi, M. B. L. Varani, L. Moser, B. Bottazzi, B. Thelen, M. Fallon, B. A. Boyman, O. Mantovani, A. Garzoni, C. Franzetti-Pellanda, A. Uguccioni, M. Robbiani, D. F.
  in Nat Immunol (2023) Vol.24 pp604-611.
  
• Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
  Bancaro, N. Cali, B. Troiani, M. Elia, A. R. Arzola, R. A. Attanasio, G. Lai, P. Crespo, M. Gurel, B. Pereira, R. Guo, C. Mosole, S. Brina, D. D'Ambrosio, M. Pasquini, E. Spataro, C. Zagato, E. Rinaldi, A. Pedotti, M. Di Lascio, S. Meani, F. Montopoli, M. Ferrari, M. Gallina, A. Varani, L. Pereira Mestre, R. Bolis, M. Gillessen Sommer, S. de Bono, J. Calcinotto, A. Alimonti, A.
  in Cancer Cell (2023) Vol.41 pp602-619.
  
• Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein
  Bianchini, F. Crivelli, V. Abernathy, M. E. Guerra, C. Palus, M. Muri, J. Marcotte, H. Piralla, A. Pedotti, M. De Gasparo, R. Simonelli, L. Matkovic, M. Toscano, C. Biggiogero, M. Calvaruso, V. Svoboda, P. Cervantes Rincon, T. Fava, T. Podesvova, L. Shanbhag, A. A. Celoria, A. Sgrignani, J. Stefanik, M. Honig, V. Pranclova, V. Michalcikova, T. Prochazka, J. Guerrini, G. Mehn, D. Ciabattini, A. Abolhassani, H. Jarrossay, D. Uguccioni, M. Medaglini, D. Pan-Hammarstrom, Q. Calzolai, L. Fernandez, D. Baldanti, F. Franzetti-Pellanda, A. Garzoni, C. Sedlacek, R. Ruzek, D. Varani, L. Cavalli, A. Barnes, C. O. Robbiani, D. F.
  in Sci Immunol (2023) Vol. ppeade0958
  
• A conformational switch controlling the toxicity of the prion protein
  Frontzek, K. Bardelli, M. Senatore, A. Henzi, A. Reimann, R. R. Bedir, S. Marino, M. Hussain, R. Jurt, S. Meisl, G. Pedotti, M. Mazzola, F. Siligardi, G. Zerbe, O. Losa, M. Knowles, T. Lakkaraju, A. Zhu, C. Schwarz, P. Hornemann, S. Holt, M. G. Simonelli, L. Varani, L. Aguzzi, A.
  in Nat Struct Mol Biol (2022) Vol.29 pp831-840
  * Marco Bardelli and Karl Frontzek contributed equally to this work (co-first), Luca Varani is corresponding authors.
• Reply to: Hultstrom et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19
  Asselta, R. Paraboschi, E. M. Stravalaci, M. Invernizzi, P. Bonfanti, P. Biondi, A. Pagani, I. Pedotti, M. Doni, A. Scavello, F. Mapelli, S. N. Sironi, M. Perucchini, C. Varani, L. Matkovic, M. Cavalli, A. Cesana, D. Gallina, P. Pedemonte, N. Capurro, V. Clementi, N. Mancini, N. Bayarri-Olmos, R. Garred, P. Rappuoli, R. Duga, S. Bottazzi, B. Uguccioni, M. Vicenzi, E. Mantovani, A. Garlanda, C.
  in Nat Immunol (2022) Vol.23 pp865-867
  
• Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules
  Stravalaci, M. Pagani, I. Paraboschi, E. M. Pedotti, M. Doni, A. Scavello, F. Mapelli, S. N. Sironi, M. Perucchini, C. Varani, L. Matkovic, M. Cavalli, A. Cesana, D. Gallina, P. Pedemonte, N. Capurro, V. Clementi, N. Mancini, N. Invernizzi, P. Bayarri-Olmos, R. Garred, P. Rappuoli, R. Duga, S. Bottazzi, B. Uguccioni, M. Asselta, R. Vicenzi, E. Mantovani, A. Garlanda, C.
  in Nat Immunol (2022) Vol.23 pp275-286
  
• Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction
  Sgrignani, J. Cecchinato, V. Fassi, E. M. A. D'Agostino, G. Garofalo, M. Danelon, G. Pedotti, M. Simonelli, L. Varani, L. Grazioso, G. Uguccioni, M. Cavalli, A.
  in J Med Chem (2021) Vol.64 pp13439-13450.
  
• Rational engineering of the lccbeta T. versicolor laccase for the mediator-less oxidation of large polycyclic aromatic hydrocarbons
  Chiado, A. Bosco, F. Bardelli, M. Simonelli, L. Pedotti, M. Marmo, L. Varani, L.
  in Comput Struct Biotechnol J (2021) Vol.19 pp2213-2222
  
• SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface
  Bertoglio, F. Meier, D. Langreder, N. Steinke, S. Rand, U. Simonelli, L. Heine, P. A. Ballmann, R. Schneider, K. T. Roth, K. D. R. Ruschig, M. Riese, P. Eschke, K. Kim, Y. Schackermann, D. Pedotti, M. Kuhn, P. Zock-Emmenthal, S. Wohrle, J. Kilb, N. Herz, T. Becker, M. Grasshoff, M. Wenzel, E. V. Russo, G. Kroger, A. Brunotte, L. Ludwig, S. Fuhner, V. Kramer, S. D. Dubel, S. Varani, L. Roth, G. Cicin-Sain, L. Schubert, M. Hust, M.
  in Nat Com (2021) Vol.12 pp1577
  
• Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
  De Gasparo, R. Pedotti, M. Simonelli, L. Nickl, P. Muecksch, F. Lorenzi, J. C. C. Mazzola, F. Magrì, D. Michalcikova, T. Haviernik, J. Honig, V. Cassaniti, I. Percivalle, E. Mrazkova, B. Polakova,N. Fortova, A. Tureckova, J. Iatsiuk, V. Di Girolamo, S. Palus, P. Zudova, D. Bednar, P. Bukova, I. Bianchini, F. Mehn, D. Nencka, R. Strakova, P. Pavlis, O. Rozman, J. Gioria, S. Sammartino, J. C. Giardina, F. Gaiarsa, S. Hammarström, Q. P. Barnes, C. O. Piralla, A. Bjorkman, P. J. Baldanti, F. Calzolai, L. Nussenzweig, M. C. Bieniasz, P. D. Hatziioannou, T. Prochazka, J. Sedlacek, R. Robbiani, D. F. Ruzek, D. Varani, L.
  in Nature (2021) Vol.593 pp424-428
  * D. Robbiani, D. Ruzek, L. Varani are co-correspnding author. Raoul De Gasparo and Mattia Pedotti contributed equally
• A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
  Bardelli, M. Frontzek, K. Simonelli, L. Pedotti, M. Mazzola, F. Carta, M. Eckhardt, V. D'Antuono, R. Virgilio, T. Gonzalez, S. F. Aguzzi, A. Varani, L.
  in PLoS Pathog (2018) Vol.14 ppe1007335
  
• Mapping Antibody Epitopes by Solution NMR Spectroscopy: Practical Considerations
  Simonelli, L. Pedotti, M. Bardelli, M. Zerbe, O. Varani, L.
  in Methods Mol Biol (2018) Vol.1785 pp29-51
  
• Label-Free Biosensor Detection of Endocrine Disrupting Compounds Using Engineered Estrogen Receptors
  La Spina, R. Ferrero, V. E. V. Aiello, V. Varani, L. Lettieri, T. Calzolai, L. Haasnoot, W. Colpo, P.
  in Biosensors (Basel) (2017) Vol.8 pp
  
• A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
  Wang, J. Bardelli, M. Espinosa, D. A. Pedotti, M. Ng, T. S. Bianchi, S. Simonelli, L. Lim, E. X. Y. Foglierini, M. Zatta, F. Jaconi, S. Beltramello, M. Cameroni, E. Fibriansah, G. Shi, J. Barca, T. Pagani, I. Rubio, A. Broccoli, V. Vicenzi, E. Graham, V. Pullan, S. Dowall, S. Hewson, R. Jurt, S. Zerbe, O. Stettler, K. Lanzavecchia, A. Sallusto, F. Cavalli, A. Harris, E. Lok, S. M. Varani, L. Corti, D.
  in Cell (2017) Vol.171 pp229-241 e15
  
• Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
  Stettler, K. Beltramello, M. Espinosa, D. A. Cassotta, A. Bianchi, S. Vanzetta, F. Minola, A. Jaconi, S. Mele, F. Foglierini, M. Pedotti, M. Simonelli, L. Dowall, S. Atkinson, B. Percivalle, E. Simmons, C. P. Varani, L. Blum, J. Baldanti, F. Cameroni, E. Hewson, R. Harris, E. Lanzavecchia, A. Sallusto, F.Corti, D.
  in Science (2016) Vol.353 pp823-6
  K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
• Antibody Binding Modulates Conformational Exchange in Domain III of Dengue Virus E Protein
  Moraes, A. H. Simonelli, L. Pedotti, M. Varani, L. Valente, A. P.
  in J Virol (2015) Vol.90 pp1802-11
  * Luca Varani is co-corresponding author
• Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
  Corti, D. Zhao, J. Pedotti, M. Agnihothram, S. Fett, C. Fernandez-Rodriguez, B. Foglierini, M. Agatic, G. Vanzetta, F. Gopal, R. Langrish, C. J. Barrett, N. A. Sallusto, F. Baric, R. S. Varani, L. Zambon, M. Perlman, S. Lanzavecchia, A.
  in Proc Natl Acad Sci U S A (2015) Vol.112 pp10473-8
  D.C. and J.Z. contributed equally to this work.
• Epitope mapping by solution NMR spectroscopy
  Bardelli, M. Livoti, E. Simonelli, L. Moraes, A. Valente, A. P. Varani, L.
  in J Mol Recognit (2015) Vol.28 pp393-400
  * Luca Varani is co-corresponding author
• Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities
  Pedotti, M. Ferrero, V. E. Lettieri, T. Follonier, S. Calzolai, L. Varani, L.
  in Int J Environ Res Public Health (2015) Vol.12 pp2612-21
  
• Rational modification of estrogen receptor by combination of computational and experimental analysis
  Ferrero, V. E. Pedotti, M. Chiado, A. Calzolai, L. Lettieri, T. Varani, L.
  in PLoS One (2014) Vol.9 ppe102658
  
• Receptor-based high-throughput screening and identification of estrogens in dietary supplements using bioaffinity liquid-chromatography ion mobility mass spectrometry
  Aqai, P. Blesa, N. G. Major, H. Varani, L. Ferrero, V. E. Haasnoot, W. Nielen, M. W.
  in Anal Bioanal Chem (2013) Vol.405 pp9427-36
  
• Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking
  Simonelli, L. Pedotti, M. Beltramello, M. Calzolai, L. Sallusto, F. Lanzavecchia, A. Varani, L.
  in PLoS One (2013) Vol.8 ppe55561
  Luca Simonelli, Mattia Pedotti contributed equally to this work.
• HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
  Schiraldi, M. Raucci, A. Munoz, L. M. Celona, B. Venereau, E. Apuzzo, T. De Marchis, F. Pedotti, M. Bachi, A. Thelen, M. Varani, L. Mellado, M. Proudfoot, A. Bianchi, M. E. Uguccioni, M.
  in J Exp Med (2012) Vol.209 pp551-63
  * Highlights, Nat. Rev. Immunol. 2012, 12:232
• Computational docking of antibody-antigen complexes, opportunities and pitfalls illustrated by influenza hemagglutinin
  Pedotti, M. Simonelli, L. Livoti, E. Varani, L.
  in Int J Mol Sci (2011) Vol.12 pp226-51
  * * Luca Simonelli and Mattia Pedotti contributed equally