Mele Federico, PhD

Publications

• Persistent longitudinal T cell responses after SARS-CoV-2 mRNA vaccines in MS patients on different disease modifying treatments
  Disanto, G. Galante, A. Sacco, R. Mallucci, G. Mele, F. Sallusto, F. Zecca, C. Gobbi, C.
  in Mult Scler Relat Disord (2024) Vol.90 pp105813
  
• Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
  Colucci, M. Zumerle, S. Bressan, S. Gianfanti, F. Troiani, M. Valdata, A. D'Ambrosio, M. Pasquini, E. Varesi, A. Cogo, F. Mosole, S. Dongilli, C. Desbats, M. A. Contu, L. Revankdar, A. Chen, J. Kalathur, M. Perciato, M. L. Basilotta, R. Endre, L. Schauer, S. Othman, A. Guccini, I. Saponaro, M. Maraccani, L. Bancaro, N. Lai, P. Liu, L. Pernigoni, N. Mele, F. Merler, S. Trotman, L. C. Guarda, G. Cali, B. Montopoli, M. Alimonti, A.
  in Cancer Cell (2024) Vol. pp
  
• SARS-CoV-2 infection and cognition in community-dwelling and nursing home residents in southern Switzerland
  Rizzi, G. Pacifico, D. Sabatini, S. Annoni, A. M. Mele, F. Jovic, S. Piccoli, L. Corna, L. Amati, R. Pertoldi, W. Fiordelli, M. Sallusto, F. Albanese, E.
  in Brain Behav Immun Health (2023) Vol.35 pp100701
  
• Human IL-23 is essential for IFN-gamma-dependent immunity to mycobacteria
  Philippot, Q. Ogishi, M. Bohlen, J. Puchan, J. Arias, A. A. Nguyen, T. Martin-Fernandez, M. Conil, C. Rinchai, D. Momenilandi, M. Mahdaviani, S. A. Keramatipour, M. Rosain, J. Yang, R. Khan, T. Neehus, A. L. Materna, M. Han, J. E. Peel, J. Mele, F. Weisshaar, M. Jovic, S. Bastard, P. Levy, R. Le Voyer, T. Zhang, P. Maglorius Renkilaraj, M. R. L. Arango-Franco, C. A. Pelham, S. Seeleuthner, Y. Pochon, M. Ata, M. M. A. Al Ali, F. Migaud, M. Soudee, C. Kochetkov, T. Molitor, A. Carapito, R. Bahram, S. Boisson, B. Fieschi, C. Mansouri, D. Marr, N. Okada, S. Shahrooei, M. Parvaneh, N. Chavoshzadeh, Z. Cobat, A. Bogunovic, D. Abel, L. Tangye, S. G. Ma, C. S. Beziat, V. Sallusto, F. Boisson-Dupuis, S. Bustamante, J. Casanova, J. L. Puel, A.
  in Sci Immunol (2023) Vol.8 ppeabq5204
  
• Clonal composition and persistence of antigen-specific circulating T follicular helper cells
  Hu, M. Notarbartolo, S. Foglierini, M. Jovic, S. Mele, F. Jarrossay, D. Lanzavecchia, A. Cassotta, A. Sallusto, F.
  in Eur J Immunol (2022) Vol.53 ppe2250190.
  
• Longitudinal Postvaccine SARS-CoV-2 Immunoglobulin G Titers, Memory B-Cell Responses, and Risk of COVID-19 in Multiple Sclerosis Over 1 Year
  Disanto, G. Galante, A. Cantu, M. Sacco, R. Mele, F. Eisler, J. J. Keller, F. Bernasconi, E. Sallusto, F. Zecca, C. Gobbi, C.
  in Neurol Neuroimmunol Neuroinflamm (2022) Vol.10 pp:e200043.
  
• ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
  Low, J. S. Jerak, J. Tortorici, M. A. McCallum, M. Pinto, D. Cassotta, A. Foglierini, M. Mele, F. Abdelnabi, R. Weynand, B. Noack, J. Montiel-Ruiz, M. Bianchi, S. Benigni, F. Sprugasci, N. Joshi, A. Bowen, J. E. Stewart, C. Rexhepaj, M. Walls, A. C. Jarrossay, D. Morone, D. Paparoditis, P. Garzoni, C. Ferrari, P. Ceschi, A. Neyts, J. Purcell, L. A. Snell, G. Corti, D. Lanzavecchia, A. Veesler, D. Sallusto, F.
  in Science (2022) Vol. ppeabq2679
  
• High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency
  Yang, R. Weisshaar, M. Mele, F. Benhsaien, I. Dorgham, K. Han, J. Croft, C. A. Notarbartolo, S. Rosain, J. Bastard, P. Puel, A. Fleckenstein, B. Glimcher, L. H. Di Santo, J. P. Ma, C. S. Gorochov, G. Bousfiha, A. Abel, L. Tangye, S. G. Casanova, J. L. Bustamante, J. Sallusto, F.
  in J Exp Med (2021) Vol.218 ppe20202726
  
• Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2
  Low, J. S. Vaqueirinho, D. Mele, F. Foglierini, M. Jerak, J. Perotti, M. Jarrossay, D. Jovic, S. Perez, L. Cacciatore, R. Terrot, T. Pellanda, A. F. Biggiogero, M. Garzoni, C. Ferrari, P. Ceschi, A. Lanzavecchia, A. Sallusto, F. Cassotta, A.
  in Science (2021) Vol.372 pp1336-1341
  
• Risk assessment and seroprevalence of SARS-CoV-2 infection in healthcare workers of COVID-19 and non-COVID-19 hospitals in Southern Switzerland
  Piccoli, L. Ferrari, P. Piumatti, G. Jovic, S. Fernandez Rodriguez, B. Mele, F. Giacchetto-Sasselli, I. Terrot, T. Silacci-Fregni, C. Cameroni, E. Jaconi, S. Sprugasci, N. Bartha, I. Corti, D. Uguccioni, M. Lanzavecchia, A. Garzoni, C. Giannini, O. Bernasconi, E. Elzi, L. Albanese, E. Sallusto, F. Ceschi, A.
  in The Lancet Regional Health - Europe (2020) Vol.1 pp100013
  
• Human T-bet Governs Innate and Innate-like Adaptive IFN-gamma Immunity against Mycobacteria
  Yang, R. Mele, F. Worley, L. Langlais, D. Rosain, J. Benhsaien, I. Elarabi, H. Croft, C. A. Doisne, J. M. Zhang, P. Weisshaar, M. Jarrossay, D. Latorre, D. Shen, Y. Han, J. Ogishi, M. Gruber, C. Markle, J. Al Ali, F. Rahman, M. Khan, T. Seeleuthner, Y. Kerner, G. Husquin, L. T. Maclsaac, J. L. Jeljeli, M. Errami, A. Ailal, F. Kobor, M. S. Oleaga-Quintas, C. Roynard, M. Bourgey, M. El Baghdadi, J. Boisson-Dupuis, S. Puel, A. Batteux, F. Rozenberg, F. Marr, N. Pan-Hammarstrom, Q. Bogunovic, D. Quintana-Murci, L. Carroll, T. Ma, C. S. Abel, L. Bousfiha, A. Di Santo, J. P. Glimcher, L. H. Gros, P. Tangye, S. G. Sallusto, F. Bustamante, J. Casanova, J. L.
  in Cell (2020) Vol.183 pp1826-1847
  
• Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology
  Piccoli, L. Park, Y. J. Tortorici, M. A. Czudnochowski, N. Walls, A. C. Beltramello, M. Silacci-Fregni, C. Pinto, D. Rosen, L. E. Bowen, J. E. Acton, O. J. Jaconi, S. Guarino, B. Minola, A. Zatta, F. Sprugasci, N. Bassi, J. Peter, A. De Marco, A. Nix, J. C. Mele, F. Jovic, S. Rodriguez, B. F. Gupta, S. V. Jin, F. Piumatti, G. Lo Presti, G. Pellanda, A. F. Biggiogero, M. Tarkowski, M. Pizzuto, M. S. Cameroni, E. Havenar-Daughton, C. Smithey, M. Hong, D. Lepori, V. Albanese, E. Ceschi, A. Bernasconi, E. Elzi, L. Ferrari, P. Garzoni, C. Riva, A. Snell, G. Sallusto, F. Fink, K. Virgin, H. W. Lanzavecchia, A. Corti, D. Veesler, D.
  in Cell (2020) Vol.183 pp1024-1042
  
• Human IFN-gamma immunity to mycobacteria is governed by both IL-12 and IL-23
  Martinez-Barricarte, R. Markle, J. G. Ma, C. S. Ramirez-Alejo, N. Mele, F. Latorre, D. Mahdaviani, S. A. Aytekin, C. Mansouri, D. Bryant, V. L. Jabot-Hanin, F. Deswarte, C. Nieto-Patlan, A. Surace, L. Kerner, G. Itan, Y. Jovic, S. Avery, D. T. Wong, N. Rao, G. Patin, E. Okada, S. Bigio, B. Boisson, B. Rapaport, F. Seeleuthner, Y. Schmidt, M. Ikinciogullari, A. Dogu, F.
  in Sci Immunol (2018) Vol.3 ppii: eaau6759
  
• T cells in patients with narcolepsy target self-antigens of hypocretin neurons
  Latorre, D. Kallweit, U. Armentani, E. Mele, F. Cassotta, A. Jovic, S. Jarrossay, D. Mathis, J. Zellini, F. Becher, B. Lanzavecchia, A. Khatami, R. Manconi, M. Tafti, M. Bassetti, C. L. Sallusto, F.
  in Nature (2018) Vol.562 pp63-68
  
• Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
  Kong, X. F. Martinez-Barricarte, R. Kennedy, J. Lazarov, T. Deenick, E. K. Ma, C. S. Breton, G. Lucero, K. B. Langlais, D. Bousfiha, A. Aytekin, C. Markle, J. Trouillet, C. Jabot-Hanin, F. Arlehamn, C. S. L. Rao, G. Picard, C. Lasseau, T. Latorre, D. Hambleton, S. Deswarte, C. Itan, Y. Abarca, K. Moraes-Vasconcelos, D. Ailal, F. Ikinciogullari, A. Dogu, F. Benhsaien, I. Sette, A.
  in Nat Immunol (2018) Vol.19 pp973-985
  
• Phenotype and specificity of T cells in primary human cytomegalovirus infection during pregnancy: IL-7Rpos long-term memory phenotype is associated with protection from vertical transmission
  Mele, F. Fornara, C. Jarrossay, D. Arossa, A. Spinillo, A. Lanzavecchia, A. Gerna, G. Sallusto, F. Lilleri, D.
  in PLoS One (2017) Vol.12 ppe0187731
  
• Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection
  Stettler, K. Beltramello, M. Espinosa, D. A. Cassotta, A. Bianchi, S. Vanzetta, F. Minola, A. Jaconi, S. Mele, F. Foglierini, M. Pedotti, M. Simonelli, L. Dowall, S. Atkinson, B. Percivalle, E. Simmons, C. P. Varani, L. Blum, J. Baldanti, F. Cameroni, E. Hewson, R. Harris, E. Lanzavecchia, A. Sallusto, F.Corti, D.
  in Science (2016) Vol.353 pp823-6
  K. S and M. B contributed equally to this work; D. A. E. ; V. G. ; A. C. ; S. B. and F. V contributed equally to this work; F. S. and D. C contributed equally to this work and are co-corresponding authors.
• Follicular helper T-cells and virus-specific antibody response in primary and reactivated human cytomegalovirus infections of the immunocompetent and immunocompromised transplanted patients
  Bruno, F. Fornara, C. Zelini, P. Carrara, E. Scaramuzzi, L. Cane, I. Mele, F. Sallusto, F. Lilleri, D. Gerna, G.
  in J Gen Virol (2016) Vol.97 pp1928-41
  
• IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
  Okada, S. Markle, J. G. Deenick, E. K. Averbuch, D. Lagos, M. Alzahrani, M. Al-Muhsen, S. Halwani, R. Ma, C. S. Wong, N. Soudais, C. Henderson, L. A. Marzouqa, H. Shamma, J. Gonzalez, M. Martinez-Barricarte, R. Okada, C. Avery, D. T. Latorre, D. Deswarte, C. Jabot-Hanin, F. Torrado, E. Fountain, J. Belkadi, A. Itan, Y. Boisson, B. Migaud, M. Arlehamn, C. S. Sette, A.
  in Science (2015) Vol.349 pp606-13
  
• ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
  Mele, F. Basso, C. Leoni, C. Becattini, S. Latorre, D. Lanzavecchia, A. Sallusto, F. Monticelli, S.
  in Nat Commun (2015) Vol.6 pp6431
  Federica Sallusto and Silvia Monticelli equally contributed to this work and are co-corresponding authors.
• T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines
  Becattini, S. Latorre, D. Mele, F. De Gregorio, C. Cassotta, A. Fernandez, B. Kelderman, S. Schumacher, T. N. Corti, D. Lanzavecchia, A. Sallusto, F.
  in Science (2014) Vol.347 pp400-6
  Abstract Reprint Full Text
• Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes
  Lindestam Arlehamn, C. S. Paul, S. Mele, F. Greenbaum, J. A. Vita, R. Sidney, J. Peters, B. Sallusto, F. Sette, A.
  in Proc Natl Acad Sci U S A (2014) Vol.112 ppE147-55
  
• Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3(+)CCR6(+) Th1 Subset
  Lindestam Arlehamn, C. S. Gerasimova, A. Mele, F. Swann, J. Greenbaum, J. A. Kim, Y. Sidney, J. James, E. A. Taplitz, R. McKinney, D. M. Kwok, W. W. Grey, H. Sallusto, F. Peters, B. Sette, A.
  in PLoS Pathog (2013) Vol.9 ppe1003130
  
• Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
  Zielinski, C. E. Mele, F. Aschenbrenner, D. Ronchi, F. Gattorno, M. Monticelli, S. Lanzavecchia, A. Sallusto, F.
  in Nature (2012) Vol.484 pp514-8
  
• Dissecting the human immunologic memory for pathogens
  Zielinski, C. E. Corti, D. Mele, F. Lanzavecchia, A. Sallusto, F.
  in Immunol Rev (2011) Vol.240 pp40-51