Geiger Roger, PhD

Systems Immunology
Group Leader

Via Francesco Chiesa 5
6500 Bellinzona, Switzerland

Bio

Roger Geiger obtained his Master’s and PhD degrees from ETH Zürich. During his PhD studies with Ari Helenius, Roger studied how non-enveloped viruses penetrate the host cell membrane.

He then joined the laboratory of Antonio Lanzavecchia at the Institute for Research in Biomedicine (IRB) as a SystemsX postdoctoral fellow.

His research focused on metabolic regulation of T cell responses. In 2016, Roger joined the research group of Matthias Mann at the Max Planck Institute of Biochemistry in Munich and received training in mass spectrometry-based proteomics.

In 2017, Roger started his research group at the IRB with the goal to study immune responses to tumors using systems biology approaches. He is Associate Professor at USI, EMBO Young Investigator and a recipient of an ERC Starting grant and a SERI-funded ERC Consolidator grant.

Publications

Targeting FOXA1 and FOXA2 disrupts the lineage-specific oncogenic output program in prostate cancer
Formaggio, N. Sgrignani, J. Thillaiyampalam, G. Lorenzi, C. Cassanmagnago, G. A. Coazzoli, M. Costanzo, F. Uebelhart, Y. Bossi, D. Cassiano, D. C. Rinaldi, A. Pecoraro, M. Geiger, R. Santoro, R. Bolis, M. Cavalli, A. Theurillat, J. P.
in Cell Rep (2025) Vol.44 pp116324
Proteomics of immune cells from liver tumors reveals immunotherapy targets
Canale, F. P. Neumann, J. von Renesse, J. Loggi, E. Pecoraro, M. Vogel, I. Zoppi, G. Antonini, G. Wolf, T. Jin, W. Zheng, X. La Barba, G. Birgin, E. Forkel, M. Nilsson, T. Marone, R. Mueller, H. Pelletier, N. Jeker, L. T. Civenni, G. Schlapbach, C. Catapano, C. V. Seifert, L. Seifert, A. M. Gillessen, S. De Dosso, S. Cristaudi, A. Rahbari, N. N. Ercolani, G. Geiger, R.
in Cell Genom (2023) Vol.3 pp100331
Myc controls NK cell development, IL-15-driven expansion, and translational machinery
Khameneh, H. J. Fonta, N. Zenobi, A. Niogret, C. Ventura, P. Guerra, C. Kwee, I. Rinaldi, A. Pecoraro, M. Geiger, R. Cavalli, A. Bertoni, F. Vivier, E. Trumpp, A. Guarda, G.
in Life Sci Alliance (2023) Vol.6 ppe202302069.
Metabolic modulation of tumours with engineered bacteria for immunotherapy
Canale, F. P. Basso, C. Antonini, G. Perotti, M. Li, N. Sokolovska, A. Neumann, J. James, M. J. Geiger, S. Jin, W. Theurillat, J. P. West, K. A. Leventhal, D. S. Lora, J. M. Sallusto, F. Geiger, R.
in Nature (2021) Vol. pp
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies
Chen, Y. Xu, K. Piccoli, L. Foglierini, M. Tan, J. Jin, W. Gorman, J. Tsybovsky, Y. Zhang, B. Traore, B. Silacci-Fregni, C. Daubenberger, C. Crompton, P. D. Geiger, R. Sallusto, F. Kwong, P. D. Lanzavecchia, A.
in Nature (2021) Vol.592 pp639-643
Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin
Cassotta, A. Paparoditis, P. Geiger, R. Mettu, R. R. Landry, S. J. Donati, A. Benevento, M. Foglierini, M. Lewis, D. J. M. Lanzavecchia, A. Sallusto, F.
in J Exp Med (2020) Vol.217 ppe20200206
Dynamics in protein translation sustaining T cell preparedness
Wolf, T. Jin, W. Zoppi, G. Vogel, I. A. Akhmedov, M. Bleck, C. K. E. Beltraminelli, T. Rieckmann, J. C. Ramirez, N. J. Benevento, M. Notarbartolo, S. Bumann, D. Meissner, F. Grimbacher, B. Mann, M. Lanzavecchia, A. Sallusto, F. Kwee, I. Geiger, R.
in Nat Immunol (2020) Vol.21 pp927-937
A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
Cassotta, A. Mikol, V. Bertrand, T. Le Parc, J. Ferrari, P. Dumas, J. Auer, M. Deisenhammer, F. Gastaldi, M. Franciotta, D. Silacci-Fregni, C. Fernandez Rodriguez, B. Giacchetto-Sasselli, I. Foglierini, M. Jarrossay, D. Geiger, R. Sallusto, F. Lanzavecchia, A. Piccoli, L.
in Nat Med (2019) Vol.25 pp1402-1407
Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1)
Schubert, D. Klein, M. C. Hassdenteufel, S. Yang, L. Proietti, M. Bulashevska, A. Kemming, J. Kuhn, J. Winzer, S. Rusch, S. Fliegauf, M. Schaffer, A. A. Pfeffer, S. Geiger, R. Cavalie, A. Cao, H. Yang, F. Li, Y. Rizzi, M. Eibel, H. Kobbe, R. Marks, A. L. Peppers, B. P. Hostoffer, R. W. Puck, J. M. Zimmermann, R. Grimbacher, B.
in J Allergy Clin Immunol (2017) Vol.141 pp1427-1438
Social network architecture of human immune cells unveiled by quantitative proteomics
Rieckmann, J. C. Geiger, R. Hornburg, D. Kveler, K. Jarrossay, D. Sallusto, F. Shen-Orr, S. S. Lanzavecchia, A. Mann, M. Meissner, F.
in Nat Immunol (2017) Vol.18 pp583-593
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Geiger, R. Rieckmann, J. C. Wolf, T. Feng, Y. Fuhrer, T. Kogadeeva, M. Picotti, P. Meissner, F. Mann, M. Zamboni, N. Sallusto, F. Lanzavecchia, A.
in Cell (2016) Vol.167 pp829-842 e13
Geiger R. and Lanzavecchia A are co-corresponding authors.
Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
Kabanova, A. Marcandalli, J. Zhou, T. Baxa, U. Tsybovsky, Y. Lilleri, D. Silacci-Fregni, C. Foglierini, M. Fernandez-Rodriguez, B. M. Druz, A. Zhang, B. Geiger, R. Pagani, M. Sallusto, F. Kwong, P. D. Corti, D. Lanzavecchia, A. Perez, L.
in Nat Microbiol (2016) Vol.1 pp16082
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou equally contributed to this work; Antonio Lanzavecchia1and Laurent Perez jointly supervised this work.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
Tan, J. Pieper, K. Piccoli, L. Foglierini, M. Geiger, R. Tully, C. M. Jarrossay, D. Ndungu, F. M. Wambua, J. Bejon, P. Fregni, C. S. Fernandez-Rodriguez, B. Barbieri, S. Bianchi, S. Marsh, K. Thathy, V. Corti, D. Sallusto, F. Bull, P. Lanzavecchia, A.
in Nature (2016) Vol.529 pp105-9
Joshua Tan, Kathrin Pieper, Luca Piccoli equally contributed to this work and Peter Bull and Antonio Lanzavecchia jointly supervised this work.

Geiger Roger, PhD

Bio

Publications

Istituto di Ricerca in Biomedicina

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