Ceppi Ilaria, PhD

Publications

• IFI16 senses and protects stalled replication forks
  Gamble, A. Ward, T. A. Wheeler, O. P. G. Morris, J. P. Jones, C. M. Bennett, L. G. Vernon, E. G. Thanendran, V. Ceppi, I. Halder, S. Borrello, D. Walker, T. D. J. Rajan, J. Suleiman, H. Harrison, D. Ashetiwi, M. Dunphy, G. Jackson-Jones, L. H. Cejka, P. Unterholzner, L. Staples, C. J.
  in Mol Cell (2026) Vol. pp
  
• Mechanism of trinucleotide repeat expansion by MutSbeta-MutLgamma and contraction by FAN1
  Senoussi, I. Mengoli, V. Cerana, A. Rinaldi, A. Marco, A. Reginato, G. Moro, S. G. Acharya, A. Roy, M. Jayachandran, A. Cannavo, E. Ceppi, I. Cejka, P.
  in Nat Commun (2025) Vol.16 pp9445
  
• Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition
  Mukherjee, S. Garda, C. Boffa, L. Elia, A. R. Massara, M. Balia, M. T. Brina, D. Mosole, S. Campagnari, A. Cassanmagnago, G. A. Rinaldi, A. Lazzaroni, G. Jarrossay, D. Morone, D. Ceppi, I. De Sillo, R. Giacomini, I. Craparotta, I. Di Rito, L. Barry, S. Laczko, E. Streb, S. Meani, F. Di Lascio, S. Hynes, N. Lugli, E. Puccio, S. Sammut, S. J. Perriard, U. Harder, Y. Rossi, L. Gasparri, M. L. Bolis, M. Cejka, P. Calcinotto, A.
  in Nat Commun (2025) Vol.16 pp6999
  
• ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome
  Clarke, T. L. Cho, H. M. Ceppi, I. Gao, B. Yadav, T. Silveira, G. G. Boon, R. Martinez-Pastor, B. Amoh, N. Y. A. Machin, B. Bernasocchi, T. Ashfaq, D. Mendez, J. Kamaliyan, Z. Del Rio Pantoja, J. Rogines, G. S. Crowley, B. T. McGinn, D. E. Giunta, V. Tran, O. Zackai, E. H. Lan, L. Zou, L. Emanuel, B. S. McDonald-McGinn, D. M. Cejka, P. Mostoslavsky, R.
  in Nat Cell Biol (2025) Vol.27 pp1006-1020.
  
• The PIN1-p38-CtIP signalling axis protects stalled replication forks from deleterious degradation
  Vivalda, F. Gatti, M. Manfredi, L. Dogan, H. Porro, A. Collotta, G. Ceppi, I. von Aesch, C. van Ackeren, V. Wild, S. Steger, M. Canovas, B. Cubillos-Rojas, M. Riera, A. Cejka, P. Nebreda, A. R. Dibitetto, D. Rottenberg, S. Sartori, A. A.
  in Nucleic Acids Res (2025) Vol.53 pp
  
• MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage
  Seppa, I. M. Ceppi, I. Tennakoon, M. Reginato, G. Jackson, J. Rouault, C. D. Agashe, S. Sviderskiy, V. O. Limbu, M. Lantelme, E. Meroni, A. Braunshier, S. Borrello, D. Verma, P. Cejka, P. Vindigni, A.
  in Genes Dev (2025) Vol.39 pp582-602.
  
• Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection
  Ceppi, I. Dello Stritto, M. R. Mutze, M. Braunshier, S. Mengoli, V. Reginato, G. Vo, H. M. P. Jimeno, S. Acharya, A. Roy, M. Sanchez, A. Halder, S. Howard, S. M. Guerois, R. Huertas, P. Noordermeer, S. M. Seidel, R. Cejka, P.
  in Nature (2024) Vol.634 pp492-500
  
• HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing
  Reginato, G. Dello Stritto, M. R. Wang, Y. Hao, J. Pavani, R. Schmitz, M. Halder, S. Morin, V. Cannavo, E. Ceppi, I. Braunshier, S. Acharya, A. Ropars, V. Charbonnier, J. B. Jinek, M. Nussenzweig, A. Ha, T. Cejka, P.
  in Nat Commun (2024) Vol.15 pp5789
  
• Xrs2/NBS1 promote end-bridging activity of the MRE11-RAD50 complex
  Moller, C. Sharma, R. Oz, R. Reginato, G. Cannavo, E. Ceppi, I. Sriram, K. K. Cejka, P. Westerlund, F.
  in Biochem Biophys Res Commun (2023) Vol.695 pp149464
  
• PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection
  Ceppi, I. Cannavo, E. Bret, H. Camarillo, R. Vivalda, F. Thakur, R. S. Romero-Franco, A. Sartori, A. A. Huertas, P. Guerois, R. Cejka, P.
  in Genes Dev (2023) Vol.37 pp119-135.
  
• WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures
  Mengoli, V. Ceppi, I. Sanchez, A. Cannavo, E. Halder, S. Scaglione, S. Gaillard, P. H. McHugh, P. J. Riesen, N. Pettazzoni, P. Cejka, P.
  in EMBO J (2022) Vol. ppe111998
  
• Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2
  Halder, S. Sanchez, A. Ranjha, L. Reginato, G. Ceppi, I. Acharya, A. Anand, R. Cejka, P.
  in Mol Cell (2022) Vol. pp
  
• The CDK1-TOPBP1-PLK1 axis regulates the Bloom’s syndrome helicase BLM to suppress crossover recombination in somatic cells
  Balbo Pogliano, C. Ceppi, I. Giovannini, S. Petroulaki, V. Palmer, N. Uliana, F. Gatti, M. Kasaciunaite, K. Freire, R. Seidel, R. Altmeyer, M. Cejka, P. Matos, J.
  in Sci Adv (2022) Vol.8 ppeabk0221
  
• A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans
  Chansel-Da Cruz, M. Hohl, M. Ceppi, I. Kermasson, L. Maggiorella, L. Modesti, M. de Villartay, J. P. Ileri, T. Cejka, P. Petrini, J. H. J. Revy, P.
  in Cell Rep (2020) Vol.33 pp108559
  
• Phosphorylated CtIP bridges DNA to promote annealing of broken ends
  Oz, R. Howard, S. M. Sharma, R. Tornkvist, H. Ceppi, I. Kk, S. Kristiansson, E. Cejka, P. Westerlund, F.
  in Proc Natl Acad Sci U S A (2020) Vol.117 pp21403-21412
  
• MRNIP is a replication fork protection factor
  Bennett, L. G. Wilkie, A. M. Antonopoulou, E. Ceppi, I. Sanchez, A. Vernon, E. G. Gamble, A. Myers, K. N. Collis, S. J. Cejka, P. Staples, C. J.
  in Sci. Adv. (2020) Vol.6 ppeaba5974
  
• The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2
  Mariotti, L. Wild, S. Brunoldi, G. Piceni, A. Ceppi, I. Kummer, S. Lutz, R. E. Cejka, P. Gari, K.
  in Commun Biol (2020) Vol.3 pp322
  
• Phosphorylation of the RecQ Helicase Sgs1/BLM Controls Its DNA Unwinding Activity during Meiosis and Mitosis
  Grigaitis, R. Ranjha, L. Wild, P. Kasaciunaite, K. Ceppi, I. Kissling, V. Henggeler, A. Susperregui, A. Peter, M. Seidel, R. Cejka, P. Matos, J.
  in Dev Cell (2020) Vol.53 pp706-723
  
• The internal region of CtIP negatively regulates DNA end resection
  Howard, S. M. Ceppi, I. Anand, R. Cejka, P.
  in Nucleic Acids Res (2020) Vol. pp
  
• CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection
  Ceppi, I. Howard, S. M. Kasaciunaite, K. Anand, R. Seidel, R. Cejka, P.
  in Proc Natl Acad Sci U S A (2020) Vol.117 pp8859-8869