Monticelli Silvia, PhD

Publications

• Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression
  Bataclan, M. Leoni, C. Moro, S. G. Pecoraro, M. Wong, E. H. Heissmeyer, V. Monticelli, S.
  in Life Sci Alliance (2024) Vol.7 ppe202402784
  
• Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer
  Cortesi, A. Gandolfi, F. Arco, F. Di Chiaro, P. Valli, E. Polletti, S. Noberini, R. Gualdrini, F. Attanasio, S. Citron, F. Ho, I. L. Shah, R. Yen, E. Y. Spinella, M. C. Ronzoni, S. Rodighiero, S. Mitro, N. Bonaldi, T. Ghisletti, S. Monticelli, S. Viale, A. Diaferia, G. R. Natoli, G.
  in Sci Adv (2024) Vol.10 ppeadk5386
  
• Editorial: T cell specificity and cross-reactivity – implications in physiology and pathology
  Latorre, D. Monticelli, S. Wypych, T. P. Aschenbrenner, D. Notarbartolo, S.
  in Front Immunol (2024) Vol.15 pp1385415
  
• DNA sensing and repair systems unexpectedly team up against cancer
  Monticelli, S. Cejka, P.
  in Nature (2024) Vol. pp
  
• The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells
  Leoni, C. Bataclan, M. Ito-Kureha, T. Heissmeyer, V. Monticelli, S.
  in Nat Commun (2023) Vol.14 pp3862
  
• Eomesodermin-expressing type 1 regulatory (EOMES(+) Tr1)-like T cells: Basic biology and role in immune-mediated diseases
  Geginat, J. Vasco, C. Gruarin, P. Bonnal, R. Rossetti, G. Silvestri, Y. Carelli, E. Pulvirenti, N. Scantamburlo, M. Moschetti, G. Clemente, F. Grassi, F. Monticelli, S. Pagani, M. Abrignani, S.
  in Eur J Immunol (2023) Vol. ppe2149775
  
• Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1alpha-STAT3 axis
  Virgilio, T. Bordini, J. Cascione, L. Sartori, G. Latino, I. Molina Romero, D. Leoni, C. Akhmedov, M. Rinaldi, A. Arribas, A. J. Morone, D. Seyed Jafari, S. M. Bersudsky, M. Ottolenghi, A. Kwee, I. Chiaravalli, A. M. Sessa, F. Hunger, R. E. Bruno, A. Mortara, L. Voronov, E. Monticelli, S. Apte, R. N. Bertoni, F. Gonzalez, S. F.
  in Cancer Immunol Res (2022) Vol.10 pp1525-1541
  
• The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
  Ito-Kureha, T. Leoni, C. Borland, K. Cantini, G. Bataclan, M. Metzger, R. N. Ammann, G. Krug, A. B. Marsico, A. Kaiser, S. Canzar, S. Feske, S. Monticelli, S. Konig, J. Heissmeyer, V.
  in Nat Immunol (2022) Vol. pp
  
• Emerging roles for RNA-binding proteins in T lymphocytes
  Monticelli, S.
  in Immunol Lett (2022) Vol.246 pp52-56
  
• RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells
  Chirichella, M. Bianchi, N. Dzafo, E. Foli, E. Gualdrini, F. Kenyon, A. Natoli, G. Monticelli, S.
  in PLoS Biol (2022) Vol.20 ppe3001538
  
• Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R
  De Simone, M. Chirichella, M. Emming, S. Mazzara, S. Ranzani, V. Gruarin, P. Moschetti, G. Pulvirenti, N. Maglie, S. Vasco, C. Crosti, M. C. Rossetti, G. Pagani, M. Abrignani, S. Monticelli, S. Geginat, J.
  in Eur J Immunol (2021) Vol.51 pp3243-3246
  *Silvia Monticelli and Jens Geginat are co-corresponding authors
• RNA-binding proteins and RNA methylation in myeloid cells
  Bataclan, M. Leoni, C. Monticelli, S.
  in Immunol Rev (2021) Vol. pp
  
• An optimized workflow for CRISPR-Cas9 deletion of surface and intracellular factors in primary human T lymphocytes
  Leoni, C. Bianchi, N. Vincenzetti, L. Monticelli, S.
  in PLoS One (2021) Vol.16 ppe0247232
  
• Cell-intrinsic mechanisms to restrain inflammatory responses in T lymphocytes
  Dzafo, E. Bianchi, N. Monticelli, S.
  in Immunol Rev (2021) Vol.300 pp181-193
  
• Vitamin D and IFN-β Modulate the Inflammatory Gene Expression Program of Primary Human T Lymphocytes
  Bianchi, N. Emming, S. Zecca, C. Monticelli, S.
  in Front Immunol (2020) Vol.11 pp566781
  
• A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes
  Emming, S. Bianchi, N. Polletti, S. Leoni, C. Montagner, S. Chirichella, M. Delaleu, N. Natoli, G. Monticelli, S.
  in Nat Immunol (2020) Vol.21 pp388-399
  
• Rebound of disease activity after fingolimod withdrawal: Immunological and gene expression profiling
  Sacco, R. Emming, S. Gobbi, C. Monticelli, S.
  in Mult Scler Relat Disord (2020) Vol.40 pp101927
  
• DNA (Hydroxy)Methylation in T Helper Lymphocytes
  Monticelli, S.
  in Trends Biochem Sci (2019) Vol.44 pp589-598
  
• The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent
  Vincenzetti, L. Leoni, C. Chirichella, M. Monticelli, S.
  in Eur J Immunol (2019) Vol.49 pp611-625
  
• MicroRNAs as modulators of T cell functions in cancer
  Emming, S. Chirichella, M. Monticelli, S.
  in Cancer Letters (2018) Vol.430 pp172-178
  
• Epigenetic and transcriptional control of mast cell responses
  Monticelli, S. Leoni, C.
  in F1000Res (2017) Vol.6 pp2064
  
• Transcriptional determination and functional specificity of myeloid cells: making sense of diversity
  Monticelli, S. Natoli, G.
  in Nat Rev Immunol (2017) Vol.17 pp595-607
  
• Dnmt3a restrains mast cell inflammatory responses
  Leoni, C. Montagner, S. Rinaldi, A. Polletti, S. Balestrieri, C. Monticelli, S.
  in Proc Natl Acad Sci U S A (2017) Vol.114 ppE1490-E1499
  Commented in Science (PMID: 28232567 )
• Approaches to Detect microRNA Expression in T Cell Subsets and T Cell Differentiation
  Monticelli, S. Aijo, T. Trifari, S.
  in Methods Mol Biol (2016) Vol.1514 pp153-172
  
• TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities
  Montagner, S. Leoni, C. Emming, S. Balestrieri, C. Barozzi, I. Piccolo, V. Togher, S. Ko, M. Rao, A. Natoli, G. Monticelli, S.
  in Cell Rep (2016) Vol.15 pp1566-79
  
• Epigenetics of T lymphocytes in health and disease
  Leoni, C. Vincenzetti, L. Emming, S.
  in Swiss Med Wkly (2015) Vol.145 ppw14191
  Full Text
• ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
  Mele, F. Basso, C. Leoni, C. Becattini, S. Latorre, D. Lanzavecchia, A. Sallusto, F. Monticelli, S.
  in Nat Commun (2015) Vol.6 pp6431
  Federica Sallusto and Silvia Monticelli equally contributed to this work and are co-corresponding authors.
• Reduced DNA methylation and hydroxymethylation in patients with systemic mastocytosis
  Leoni, C. Montagner, S. Deho, L. De Matteis, G. Marzano, A. V. Merante, S. Orlandi, E. M. Zanotti, R. Monticelli, S.
  in Eur J Haematol (2015) Vol.95 pp566-75
  
• Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities
  Deho, L. Leoni, C. Brodie, T. M. De Simone, M. Polletti, S. Barozzi, I. Natoli, G. Monticelli, S.
  in J Immunol (2014) Vol.193 pp2196-206
  
• MicroRNAs in hematopoietic development
  Montagner, S. Deho, L. Monticelli, S.
  in BMC Immunol (2014) Vol.15 pp14
  
• Macrophage activation: glancing into diversity
  Natoli, G. Monticelli, S.
  in Immunity (2014) Vol.40 pp175-7
  
• MicroRNAs in T helper cell differentiation and plasticity
  Monticelli, S.
  in Semin Immunol (2013) Vol.25 pp291-8
  
• The many faces of CD4 T cells: Roles in immunity and disease
  Sallusto, F. Monticelli, S.
  in Semin Immunol (2013) Vol.25 pp249-51
  
• Short-term memory of danger signals and environmental stimuli in immune cells
  Monticelli, S. Natoli, G.
  in Nat Immunol (2013) Vol.14 pp777-84
  
• The role of miRNAs in mast cells and other innate immune cells
  Montagner, S. Orlandi, E. M. Merante, S.
  in Immunol Rev (2013) Vol.253 pp12-24
  
• miR-146a and NF-kappaB1 Regulate Mast Cell Survival and T Lymphocyte Differentiation
  Rusca, N. Deho, L. Montagner, S. Sica, A. Sallusto, F. Monticelli, S.
  in Mol Cell Biol (2012) Vol.32 pp4432-44
  * Selected as "Article of significant interest" by the Editors
• Negative regulators take center stage
  Monticelli, S. Sallusto, F.
  in Nat Immunol (2012) Vol.13 pp719-20
  
• Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
  Zielinski, C. E. Mele, F. Aschenbrenner, D. Ronchi, F. Gattorno, M. Monticelli, S. Lanzavecchia, A. Sallusto, F.
  in Nature (2012) Vol.484 pp514-8
  
• MiR-146a in Immunity and Disease
  Rusca, N. Monticelli, S.
  in Mol Biol Int (2011) Vol.2011 pp437301
  
• MiR-221 Influences Effector Functions and Actin Cytoskeleton in Mast Cells
  Mayoral, R. J. Deho, L. Rusca, N. Saini, H. K. Enright, A. J. Monticelli, S.
  in PLoS One (2011) Vol.6 ppe26133
  
• Stable Overexpression of miRNAs in Bone Marrow-Derived Murine Mast Cells Using Lentiviral Expression Vectors
  Mayoral, R. J. Monticelli, S.
  in Methods Mol Biol (2010) Vol.667 pp205-14
  
• Human mast cells and mastocytosis: harnessing microRNA expression as a new approach to therapy?
  Deho, L. Monticelli, S.
  in Arch Immunol Ther Exp (Warsz) (2010) Vol.58 pp279-86
  
• MicroRNA-221-222 regulate the cell cycle in mast cells
  Mayoral, R. J. Pipkin, M. E. Pachkov, M. Rao, A. Monticelli, S.
  in J Immunol (2008) Vol.182 pp433-45
  
• Genomics and the immune system
  Pipkin, M. E. Monticelli, S.
  in Immunology (2008) Vol.124 pp23-32
  
• A role for microRNAs in the development of the immune system and in the pathogenesis of cancer
  Kanellopoulou, C. Monticelli, S.
  in Semin Cancer Biol (2008) Vol.18 pp79-88
  
• Immunological applications of genomics
  Monticelli, S. Sharma, S. Rao, A.
  in Genome Biol (2006) Vol.7 pp321
  
• Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes
  Monticelli, S. Ansel, K. M. Lee, D. U.
  in Novartis Found Symp (2006) Vol.271 pp179-87; discussion 187-90, 198-9
  
• Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells
  Monticelli, S. Lee, D. U. Nardone, J. Rao, A.
  in Int Immunol (2005) Vol.17 pp1513-24
  
• MicroRNA profiling of the murine hematopoietic system
  Monticelli, S. Ansel, K. M. Xiao, C. Krichevsky, A. M. Thai, T. H. Rajewsky, N. Marks, D. S. Sander, C. Rajewsky, K. Rao, A. Kosik, K. S.
  in Genome Biol (2005) Vol.6 ppR71
  
• Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity
  Ansel, K. M. Greenwald, R. J. Agarwal, S. Monticelli, S. Interlandi, J. Djuretic, I. M. Lee, D. U. Sharpe, A. H. Alt, F. W. Rao, A.
  in Nat Immunol (2004) Vol.5 pp1251-9
  
• Chromatin-level regulation of the IL10 gene in T cells
  Im, S. H. Hueber, A. Monticelli, S. Rao, A.
  in J Biol Chem (2004) Vol.279 pp46818-25
  
• Role of NFAT proteins in IL13 gene transcription in mast cells
  Monticelli, S. Solymar, D. C. Rao, A.
  in J Biol Chem (2004) Vol.279 pp36210-8
  
• NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription
  Monticelli, S. Rao, A.
  in Eur J Immunol (2002) Vol.32 pp2971-8
  
• Myb proteins repress human Ig epsilon germline transcription by inhibiting STAT6-dependent promoter activation
  Monticelli, S. Ghittoni, R. Kabesch, M.
  in Mol Immunol (2002) Vol.38 pp1129-38
  
• Molecular regulation of class switch recombination to IgE through epsilon germline transcription
  Monticelli, S. Vercelli, D.
  in Allergy (2001) Vol.56 pp270-8
  
• MicroRNAs and the Immune System
  Monticelli, S.
  in Methods in Molecular Biology (1970) Vol.667 pp
  
• Molecular regulation of IgE switching: let’s walk hand in hand
  Monticelli, S. De Monte, L. Vercelli, D.
  in Allergy (1998) Vol.53 pp6-8
  
• To E or not to E? Can an IL-4-induced B cell choose between IgE and IgG4?
  Vercelli, D. De Monte, L. Monticelli, S. Agresti, A.
  in Int Arch Allergy Immunol (1998) Vol.116 pp1-4
  
• The company they keep: How BSAP and other transcription factors may regulate the human ε germline promoter
  De Monte, L. Monticelli, S. Vercelli, D.
  in Progress in Allergy and Clinical Immunology (1997) Vol.4 pp
  
• The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter
  Thienes, C. P. De Monte, L. Monticelli, S. Gould, H. J. Vercelli, D.
  in J Immunol (1997) Vol.158 pp5874-82
  
• Regulation of human epsilon germline transcription: role of B-cell-specific activator protein
  De Monte, L. Thienes, C. P. Monticelli, S. Gould, H. J. Vercelli, D.
  in Int Arch Allergy Immunol (1997) Vol.113 pp35-8