González F. Santiago, PhD, PhD

Infection and Immunity
Group Leader

Via Francesco Chiesa 5
6500 Bellinzona, Switzerland

santiago.gonzalez@irb.usi.ch
+41 58 666 7226

Bio

Santiago F. González holds two PhD degrees, one in microbiology from the University of Santiago de Compostela (Spain) and one in immunology from the University of Copenhagen (Denmark). From January 2007 to September 2011 he was a postdoc in the group of Michael Carroll at the Immune Disease Institute, Harvard Medical School, in Boston (USA). He has been awarded three EU Marie Curie Fellowships, one for his postgraduate studies in Denmark where he studied skin inflammation and the connection between innate and adaptive responses from a molecular perspective. The second fellowship was a Marie Curie International Outgoing Fellowship awarded in 2008 for a project shared between Harvard Medical School and the National Center for Biotechnology (Madrid). The project focused on the study of the defense mechanism against Influenza virus. The third fellowship is the Marie Curie Career Integration Grant to establish his group at the IRB. He has published several papers related with antigen trafficking, memory B cell, and the regulation of the immune system in high impact journals. During his work at Harvard he studied the transport mechanism of an influenza vaccine in the lymph node. He found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. These results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination and were published in Nature Immunology. In November 2012 he joined the Institute for Research in Biomedicine in Bellinzona as a group leader studying pathogen-host interaction.

* SIGN-R1 responsible of influenza virus recognition

* Così il virus dell’influenza può essere bloccato appena entra

Publications

Stealth mRNA nanovaccines to control lymph node trafficking
Garcia-Fernandez, C. Virgilio, T. Latino, I. Guerra-Rebollo, M. Gonzalez, S. F. Borros, S. Fornaguera, C.
in J Control Release (2024) Vol.374 pp325-336
Plitidepsin as an Immunomodulator against Respiratory Viral Infections
Losada, A. Izquierdo-Useros, N. Aviles, P. Vergara-Alert, J. Latino, I. Segalés, J. Gonzalez, S. Cuevas, C. Raïch-Regué, D. Muñoz-Alonso, M. J. Perez-Zsolt, D. Muñoz-Basagoiti, J. Rodon, J. Chang, L. A. Warang, P. Singh, G. Brustolin, M. Cantero, G.; Roca, N. Pérez, M. Eugenio Bustos-Morán; White, K. Schotsaert, M. García-Sastre, A.
in J Immunol. (2024) Vol. pp
Transformer-based spatial-temporal detection of apoptotic cell death in live-cell imaging
Pulfer, A. Pizzagalli, D. U. Gagliardi, P. A. Hinderling, L. Lopez, P. Zayats, R. Carrillo-Barberà, P. Antonello, P. Palomino-Segura, M. Giusti, A. Thelen, M. Gambardella, L. M. Murooka, T. T. Pertz, O. Krause, R. Gonzalez, S.
in eLife (2023) Vol.12 ppRP90502
Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1alpha-STAT3 axis
Virgilio, T. Bordini, J. Cascione, L. Sartori, G. Latino, I. Molina Romero, D. Leoni, C. Akhmedov, M. Rinaldi, A. Arribas, A. J. Morone, D. Seyed Jafari, S. M. Bersudsky, M. Ottolenghi, A. Kwee, I. Chiaravalli, A. M. Sessa, F. Hunger, R. E. Bruno, A. Mortara, L. Voronov, E. Monticelli, S. Apte, R. N. Bertoni, F. Gonzalez, S. F.
in Cancer Immunol Res (2022) Vol.10 pp1525-1541
CANCOL, a Computer-Assisted Annotation Tool to Facilitate Colocalization and Tracking of Immune Cells in Intravital Microscopy
Pizzagalli, D. U. Bordini, J. Morone, D. Pulfer, A. Carrillo-Barbera, P. Thelen, B. Ceni, K. Thelen, M. Krause, R. Gonzalez, S. F.
in J Immunol (2022) Vol. pp
In Vivo Motility Patterns Displayed by Immune Cells Under Inflammatory Conditions
Pizzagalli, D. U. Pulfer, A. Thelen, M. Krause, R. Gonzalez, S. F.
in Front Immunol (2022) Vol.12 pp804159
Behavioural immune landscapes of inflammation
Crainiciuc, G. Palomino-Segura, M. Molina-Moreno, M. Sicilia, J. Aragones, D. G. Li, J. L. Y. Madurga, R. Adrover, J. M. Aroca-Crevillen, A. Martin-Salamanca, S. Del Valle, A. S. Castillo, S. D. Welch, H. C. E. Soehnlein, O. Graupera, M. Sanchez-Cabo, F. Zarbock, A. Smithgall, T. E. Di Pilato, M. Mempel, T. R. Tharaux, P. L. Gonzalez, S. F. Ayuso-Sacido, A. Ng, L. G. Calvo, G. F. Gonzalez-Diaz, I. Diaz-de-Maria, F. Hidalgo, A.
in Nature (2022) Vol. pp
Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection
Di Pilato, M. Palomino-Segura, M. Mejias-Perez, E. Gomez, C. E. Rubio-Ponce, A. D'Antuono, R. Pizzagalli, D. U. Perez, P. Kfuri-Rubens, R. Benguria, A. Dopazo, A. Ballesteros, I. Sorzano, C. O. S. Hidalgo, A. Esteban, M. Gonzalez, S. F.
in NPJ Vaccines (2021) Vol.6 pp52
Carboxymethyl-beta-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery
Cordeiro, A. S. Farsakoglu, Y. Crecente-Campo, J. de la Fuente, M. Gonzalez, S. F. Alonso, M. J.
in Drug Deliv Transl Res (2021) Vol. pp
Spatio-temporal profile of innate inflammatory cells and mediators during influenza virus infection
Latino, I. Gonzalez F., S.
in Curr Opin Physiol (2020) Vol.19 pp175-186
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger, S. Sarhan, D. Boura, V. F. Ibarlucea-Benitez, I. Tyystjarvi, S. Oliynyk, G. Arsenian-Henriksson, M. Lane, D. Wikstrom, S. L. Kiessling, R. Virgilio, T. Gonzalez, S. F. Kaczynska, D. Kanatani, S. Daskalaki, E. Wheelock, C. E. Sedimbi, S. Chambers, B. J. Ravetch, J. V. Karlsson, M. C. I.
in Proc Natl Acad Sci U S A (2020) Vol.117 pp32005-32016
Early production of IL-17A by gammadelta T cells in the trachea promotes viral clearance during influenza infection in mice
Palomino-Segura, M. Latino, I. Farsakoglu, Y. Gonzalez, S. F.
in Eur J Immunol (2019) Vol.50 pp97-109
Characterization of the Dynamic Behavior of Neutrophils Following Influenza Vaccination
Pizzagalli, D. U., Latino, I., Pulfer, A. , Virgilio, T., Farsakoglu, Y. , Krause, R., Gonzalez, S. F.
in Frontiers in Immunology (2019) Vol.10 pp2621
Design of polymeric nanocapsules to improve their lympho-targeting capacity
Crecente-Campo, J. Virgilio, T. Morone, D. Fernandez-Marino, I. Olivera, A. Varela-Calvino, R. Gonzalez, S. F. Alonso, M. J.
in Nanomedicine (Lond) (2019) Vol.14 pp3013-3033
A trainable clustering algorithm based on shortest paths from density peaks
Pizzagalli, D. U. Gonzalez, S. F. Krause, R.
in Science Advances (2019) Vol.5 ppeaax3770
Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1
Palomino-Segura, M. Perez, L. Farsakoglu, Y. Latino, I. D'Antuono, R. Chatziandreou, N. Pizzagalli, D. U. Wang, G. Garcia-Sastre, A. Sallusto, F. Carroll, M. C. Neyrolles, O. Gonzalez, S. F.
in Nat Microbiol (2019) Vol.4 pp1930-1940
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner
Farsakoglu, Y. Palomino-Segura, M. Latino, I. Chatziandreou, N. Pizzagalli, D. U. Rinaldi, A. Bolis, M. Sallusto, F. Stein, J. V. Gonzalez, S. F.
in Cell Rep (2019) Vol.26 pp2307-2315
Two-Photon Intravital Imaging of Leukocytes in the Trachea During Pneumococcal Infection
Palomino-Segura, M. Gonzalez, S. F.
in Methods Mol Biol (2019) Vol.1968 pp183-194
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
Proietti, M. Perruzza, L. Scribano, D. D'Antuono, R. Strati, F. Raffaelli, M. Gonzalez, S. F. Thelen, M. Hardt, W. D. Slack, E. Nicoletti, M. Grassi, F.
in Nat Commun (2019) Vol.10 pp250
Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system
Cordeiro, A. S. Crecente-Campo, J. Lopez-Bouzo, B. Gonzalez, S. F. de la Fuente, M. Alonso, M. J.
in J Drug Target (2019) Vol. pp1-52
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
Bardelli, M. Frontzek, K. Simonelli, L. Pedotti, M. Mazzola, F. Carta, M. Eckhardt, V. D'Antuono, R. Virgilio, T. Gonzalez, S. F. Aguzzi, A. Varani, L.
in PLoS Pathog (2018) Vol.14 ppe1007335
Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy
Palomino-Segura, M. Virgilio, T. Morone, D. Gonzalez, S.
in JoVE (2018) Vol. ppe58355
Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos
Pizzagalli, D. U. Farsakoglu, Y. Palomino-Segura, M. Sintes, J. Marangoni, F. Mempel, T. R. Koh, W. H. Murooka, T. T. Thelen, F. Stein, J. V. Pozzi, G. Thelen, M. Krause, R. Gonzalez, S. F.
in Sci Data (2018) Vol.5 pp180129
Epithelial-Mesenchymal transition in cancer metastasis through the lymphatic system
Karlsson, M. C. Gonzalez, S. F. Welin, J.
in Mol Oncol (2017) Vol.11 pp781-791
Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node
Chatziandreou, N. Farsakoglu, Y. Palomino-Segura, M. Pizzagalli, D. U. Sallusto, F. Lukacs-Kornek, V. Uguccioni, M. Corti, D. Turley, S. J. Lanzavecchia, A. Carroll, M. C. Gonzalez, S. F.
in Cell Rep (2017) Vol.18 pp2427-2440
Dynamic intravital imaging of cell-cell interactions in the lymph node
Stein, J. V. Gonzalez, S. F.
in J Allergy Clin Immunol (2017) Vol.139 pp12-20
Development of a SYBR green I real-time PCR assay for specific identification of the fish pathogen Aeromonas salmonicida subspecies salmonicida
Fernandez-Alvarez, C. Gonzalez, S. F. Santos, Y.
in Appl Microbiol Biotechnol (2016) Vol.100 pp10585-10595
Antibody-Mediated Immunity
Baumgarth, N. Carroll, M. C. Gonzalez, S. F.
in Textbook of Influenza, 2nd Edition (2013) Vol. pp
Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation
Heesters, B. A. Chatterjee, P. Kim, Y. A. Gonzalez, S. F. Kuligowski, M. P. Kirchhausen, T. Carroll, M. C.
in Immunity (2013) Vol.38 pp1164-75
Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity
Py, B. F. Gonzalez, S. F. Long, K. Kim, Y. A. Zhu, H. Yao, J. Degauque, N. Villet, R. Ymele-Leki, P. Gadjeva, M. Pier, G. B. Carroll, M. C. Yuan, J.
in Immunity (2013) Vol.38 pp1063-72
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2
Acton, S. E. Astarita, J. L. Malhotra, D. Franz, B. Hess, P. R. Jakus, Z. Kuligowski, M. Fletcher, A. L. Elpek, K. G. Bellemare-Pelletier, A. Sceats, L. Reynoso, E. D. Gonzalez, S. F. Graham, D. B. Chang, J. Peters, A. Woodruff, M. Kim, Y. A. Swat, W. Morita, T. Kuchroo, V. Carroll, M. C. Kahn, M. L. Wucherpfennig, K. W. Turley, S. J.
in Immunity (2012) Vol.37 pp276-89
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
Malhotra, D. Fletcher, A. L. Astarita, J. Tayalia, P. Gonzalez, S. F. Elpek, K. G. Chang, S. K. Knoblich, K. Hemler, M. E. Brenner, M. B. Carroll, M. C. Mooney, D. J. Turley, S. J.
in Nat Immunol (2012) Vol.13 pp499-510
Molecular cloning and expression of two beta-defensin and two mucin genes in common carp (Cyprinus carpio L.) and their up-regulation after beta-glucan feeding
Marel, Mv Adamek, M. Gonzalez, S. F. Rombout, J. H. Wiegertjes, G. F. Savelkoul, H. F. Steinhagen, D.
in Fish Shellfish Immunol (2012) Vol.32 pp494-501
Trafficking of B cell antigen in lymph nodes
Gonzalez, S. F. Degn, S. E. Pitcher, L. A. Heesters, B. A. Carroll, M. C.
in Annu Rev Immunol (2011) Vol.29 pp215-33
The role of innate immunity in B cell acquisition of antigen within LNs
Gonzalez, S. F. Kuligowski, M. P. Pitcher, L. A. Carroll, M. C.
in Adv Immunol (2010) Vol.106 pp1-19
Complement-dependent transport of antigen into B cell follicles
Gonzalez, S. F. Lukacs-Kornek, V. Kuligowski, M. P. Degn, S. E. Turley, S. J. Carroll, M. C.
in J Immunol (2010) Vol.185 pp2659-64
SIGN-R1-expressing dendritic cells are important for humoral immunity to influenza virus
Pitcher, L. A. Gonzalez, S. F. Lukacs-Kornek, V. Kim, Y. A. Martinez-Pomares, L. Gordon, S. Turley, S. J. Carroll, M. C.
in Mol Immunol (2010) Vol.47 pp2227-2227
The role of the complement system in trafficking of a Streptococcus vaccine in the lymph node
Heesters, B. A. Gonzalez, S. F. Carroll, M. C.
in Mol Immunol (2010) Vol.47 pp2249-2249
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes
Gonzalez, S. F. Lukacs-Kornek, V. Kuligowski, M. P. Degn, S. E. Kim, Y. A. Cloninger, M. J. Martinez-Pomares, L. Gordon, S. Turley, S. J. Carroll, M. C.
in Nat Immunol (2010) Vol.11 pp427-34
Serological methods for the detection of pathogenic bacteria in aquaculture: Present status and future prospects
Gonzalez, S. F. Santos, Y.
in Fisheries, aquaculture and biotechnology (2009) Vol. pp
B cell acquisition of antigen in vivo
Gonzalez, S. F. Pitcher, L. A. Mempel, T. Carroll, M. C.
in Curr Opin Immunol (2009) Vol.21 pp251-7
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
Roozendaal, R. Mempel, T. R. Pitcher, L. A. Verschoor, A. Mebius, R. E. von Andrian, U. H. Carroll, M. C.
in Immunity (2009) Vol.30 pp264-76
Genomic resources and microarrays for the common carp Cyprinus carpio L.
Williams, D. R. Li, W. Hughes, M. A. Vernon, C. Vidal, M. C. Jeney, Z. Jeney, G. Dixon, P. McAndrew, B. Bartfai, R. Orban, L. Trudeau, V. Rogers, J. Matthews, L. Fraser, E. J. Gracey, A. Y. Cossins, A. R.
in J Fish Biology (2008) Vol.72 pp2095-2117
Differential transcription of multiple forms of alpha-2-macroglobulin in carp (Cyprinus carpio) infected with parasites
Onara, D. F. Forlenza, M. Gonzalez, S. F. Pilarczyk, A. Irnazarow, I. Wiegertjes, G. F.
in Dev Comp Immunol (2007) Vol.32 pp339-47
Complement expression in common carp (Cyprinus carpio L.) during infection with Ichthyophthirius multifiliis
Gonzalez, S. F. Buchmann, K. Nielsen, M. E.
in Dev Comp Immunol (2006) Vol.31 pp576-86
Ichthyophthirius multifiliis infection induces massive up-regulation of serum amyloid A in carp (Cyprinus carpio)
Gonzalez, S. F. Buchmann, K. Nielsen, M. E.
in Vet Immunol Immunopathol (2006) Vol.115 pp172-8
Cutaneous immune responses in the common carp detected using transcript analysis
Gonzalez, S. F. Chatziandreou, N. Nielsen, M. E. Rogers, J. Taylor, R. Santos, Y. Cossins, A.
in Mol Immunol (2006) Vol.44 pp1664-79
Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses caused by the ectoparasite Ichthyophthirius multifiliis
Gonzalez, S. F. Buchmann, K. Nielsen, M. E.
in Fish Shellfish Immunol (2006) Vol.22 pp641-50
Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses to injury mimicking infection with ectoparasites
Gonzalez, S. F. Huising, M. O. Stakauskas, R. Lidy Verburg-van Kemenade, B. M. Buchmann, K. Nielsen, M. E. Wiegertjes, G. F.
in Dev Comp Immunol (2006) Vol.31 pp244-54
Evaluation of the AQUARAPID-Va, AQUAEIA-Va and dot-blot assays for the detection of Vibrio anguillarum in fish tissues
Gonzalez, S. F. Osorio, C. R. Santos, Y.
in J Fish Dis (2004) Vol.27 pp617-21
Simultaneous detection of marine fish pathogens by using multiplex PCR and a DNA microarray
Gonzalez, S. F. Krug, M. J. Nielsen, M. E. Call, D. R.
in J Clin Microbiol (2004) Vol.42 pp1414-9
Development of a PCR-based method for the detection of Listonella anguillarum in fish tissues and blood samples
Gonzalez, S. F. Osorio, C. R. Santos, Y.
in Dis Aquat Organ (2003) Vol.55 pp109-15

González F. Santiago, PhD, PhD

Bio

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Istituto di Ricerca in Biomedicina

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