{"id":7796,"date":"2006-06-17T00:00:00","date_gmt":"2006-06-16T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/elena-palmesino-phd-thesis-2\/"},"modified":"2006-06-17T00:00:00","modified_gmt":"2006-06-16T22:00:00","slug":"elena-palmesino-phd-thesis-2","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/","title":{"rendered":"Elena Palmesino PhD Thesis"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">June 17, 2006<\/span><\/p>\n<h3>CXCR4 associated proteins and their role in cell specific receptor function<\/h3>\n<p><em>Elena Palmesino and Marcus Thelen<\/em><\/p>\n<p>Understanding chemokine receptor-mediated signaling in different cellular environments is the main focus of the project. Ample evidence from our laboratory and by others indicate that coupling of a given G-protein coupled receptor to downstream signaling cascades must be regulated in close proximity to the receptor and may vary between cell types.<\/p>\n<p>As a model we investigate the signaling properties of the chemokine receptor CXCR4 which regulates trafficking of leukocytes and tissue cells and is involved in tumor metastasis. The receptor also mediates cell survival and is important in organogenesis. However, CXCR4-stimulated intracellular signaling depends on the cell system. To characterize receptor-associated proteins, that determine the fate of CXCR4medited cell activation, we developed a solubilization protocol that does not affect the structural integrity of CXCR4, and in which solubilized CXCR4 retains is ability to bind CXCL12. Current investigations should lead to the identification of receptor associated proteins in differ ent cellular systems. Analysis of the expression patterns of the proteins will provide clues on their function in the regulation of CXCR4 activity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>on June 17, 2006 CXCR4 associated proteins and their role in cell specific receptor function Elena Palmesino and Marcus Thelen Understanding chemokine receptor-mediated signaling in different cellular environments is the main focus of the project. Ample evidence from our laboratory and by others indicate that coupling of a given G-protein coupled receptor to downstream signaling [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Elena Palmesino PhD Thesis - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Elena Palmesino PhD Thesis - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on June 17, 2006 CXCR4 associated proteins and their role in cell specific receptor function Elena Palmesino and Marcus Thelen Understanding chemokine receptor-mediated signaling in different cellular environments is the main focus of the project. Ample evidence from our laboratory and by others indicate that coupling of a given G-protein coupled receptor to downstream signaling [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2006-06-16T22:00:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"1 minuto\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/\",\"name\":\"Elena Palmesino PhD Thesis - IRB USI\",\"isPartOf\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\"},\"datePublished\":\"2006-06-16T22:00:00+00:00\",\"dateModified\":\"2006-06-16T22:00:00+00:00\",\"author\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\"},\"breadcrumb\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"url\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"name\":\"News\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/elena-palmesino-phd-thesis-2\/\",\"name\":\"Elena Palmesino PhD Thesis\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\",\"name\":\"AD_Dave\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7796"}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=7796"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7796\/revisions"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=7796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=7796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=7796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}