{"id":7776,"date":"2018-09-10T00:00:00","date_gmt":"2018-09-09T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/"},"modified":"2018-09-10T00:00:00","modified_gmt":"2018-09-09T22:00:00","slug":"new-paper-by-the-sallusto-lab-published-in-nature-immunology-2","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/","title":{"rendered":"New paper by the Sallusto lab published in Nature Immunology"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">September 10, 2018<\/span><\/p>\n<p class=\"rtejustify\">T helper lymphocytes that produce IL-17 (T<sub>H<\/sub>17 cells) are pivotal in protection against extracellular bacteria and fungi. They exert this function by recruiting neutrophils and by secreting a wide range of pro-inflammatory cytokines and effector molecules. T<sub>H<\/sub>17 cells can also induce severe tissue damage and chronic inflammation, eventually leading to autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis and Crohn\u2019s disease. In the study entitled \u201cAn immunoregulatory and tissue-residency program modulated by c-MAF in human T<sub>H<\/sub>17 cells\u201d and published in <em>Nature Immunology<\/em>, the research team led by prof. Federica Sallusto characterized two subsets of human T<sub>H<\/sub>17 cells that could be distinguished on the basis of their expression of the anti-inflammatory cytokine IL-10. IL-10-positive T<sub>H<\/sub>17 cells expressed a variety of genes encoding immunoregulatory molecules, as well as genes whose expression is characteristic of tissue-resident T cells. In contrast, IL-10-negative T<sub>H<\/sub>17 cells possessed a pro-inflammatory gene-expression profile and upregulated expression of homing receptors that guide recirculation from tissues to blood. The data further demonstrated that the immunoregulatory and tissue-residency program of IL-10-positive T<sub>H<\/sub>17 cells is modulated by c-MAF, which binds to a large number of regulatory regions, acting as a transcriptional co-activator or co-repressor in a context dependent manner. The characterization of human T<sub>H<\/sub>17 cells with programmed opposing fates sets the stage for studying their physiological functions and opens new possibilities for therapeutic interventions in autoimmune pathologies.<\/p>\n<table border=\"1\" cellpadding=\"1\" cellspacing=\"1\" dir=\"ltr\" style=\"width:500px; margin-right:20px\">\n<tbody>\n<tr>\n<td><img loading=\"lazy\" alt=\"\" dir=\"ltr\" height=\"364\" src=\"\/images\/natimmunol_sept2018.jpg\" style=\"float: left;\" width=\"747\"><\/td>\n<\/tr>\n<tr>\n<td>Immuno-regulatory and pro-inflammatory human T<sub>H<\/sub>17 cells<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The work was supported by the European Research Council, the Swiss National Science Foundation and the National Institutes of Health.<\/p>\n<p><strong>Article<\/strong><\/p>\n<p>An immunoregulatory and tissue-residency program modulated by c-MAF in human T<sub>H<\/sub>17 cells<\/p>\n<p>Dominik Aschenbrenner, Mathilde Foglierini, David Jarrossay, Dan Hu, Howard L. Weiner, Vijay K. Kuchroo, Antonio Lanzavecchia, Samuele Notarbartolo<sup>*<\/sup> and Federica Sallusto<sup>*<\/sup>.<\/p>\n<p><sup>*<\/sup>equal contribution<\/p>\n<p>Nature Immunology, DOI: <a href=\"https:\/\/www.nature.com\/articles\/s41590-018-0200-5\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41590-018-0200-5<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>on September 10, 2018 T helper lymphocytes that produce IL-17 (TH17 cells) are pivotal in protection against extracellular bacteria and fungi. They exert this function by recruiting neutrophils and by secreting a wide range of pro-inflammatory cytokines and effector molecules. TH17 cells can also induce severe tissue damage and chronic inflammation, eventually leading to autoimmune [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New paper by the Sallusto lab published in Nature Immunology - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper by the Sallusto lab published in Nature Immunology - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on September 10, 2018 T helper lymphocytes that produce IL-17 (TH17 cells) are pivotal in protection against extracellular bacteria and fungi. They exert this function by recruiting neutrophils and by secreting a wide range of pro-inflammatory cytokines and effector molecules. TH17 cells can also induce severe tissue damage and chronic inflammation, eventually leading to autoimmune [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-09T22:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/natimmunol_sept2018.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"2 minuti\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/#primaryimage\",\"inLanguage\":\"it-IT\",\"url\":\"\/images\/natimmunol_sept2018.jpg\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/\",\"name\":\"New paper by the Sallusto lab published in Nature Immunology - IRB USI\",\"isPartOf\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/#primaryimage\"},\"datePublished\":\"2018-09-09T22:00:00+00:00\",\"dateModified\":\"2018-09-09T22:00:00+00:00\",\"author\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\"},\"breadcrumb\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"url\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"name\":\"News\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-sallusto-lab-published-in-nature-immunology-2\/\",\"name\":\"New paper by the Sallusto lab published in Nature Immunology\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\",\"name\":\"AD_Dave\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7776"}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=7776"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7776\/revisions"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=7776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=7776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=7776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}