{"id":7764,"date":"2018-10-08T00:00:00","date_gmt":"2018-10-07T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/new-paper-from-the-cavalli-lab-2\/"},"modified":"2018-10-08T00:00:00","modified_gmt":"2018-10-07T22:00:00","slug":"new-paper-from-the-cavalli-lab-2","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-paper-from-the-cavalli-lab-2\/","title":{"rendered":"New paper from the Cavalli Lab"},"content":{"rendered":"

on<\/span> October 8, 2018<\/span><\/p>\n

Pyruvate (PYR) dehydrogenase complex (PDC) is an enzymatic system that plays a crucial role in cellular metabolism as it controls the entry of carbon into the Krebs cycle. Recent experimental investigations highlighted its important role in cancer metabolism and indicated it as a potential target for the development of new anticancer therapies.<\/p>\n

In the study entitled \u2018How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study<\/em>\u2019, published in Scientific Reports<\/em>, a team of scientists led by Andrea Cavalli clarified by computational techniques how this enzyme is regulated by phosphorylation of specific serine residues.<\/p>\n

The results of this work improve the knowledge of the PDC functional mechanism and suggest new strategies of pharmacological intervention in both cancer and rare metabolic diseases.<\/p>\n\n\n\n\n
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Structure of the E1 subunit of the pyruvate dehydrogenase complex (PDC). The atoms of the phosphorylated serine residues are depicted as balls<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Article<\/strong><\/p>\n

How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study<\/a>
\nJ. Sgrignani, J. Chen, A. Alimonti, A. Cavalli
\nin Sci Rep (2018) vol. 8 pp14683<\/p>\n","protected":false},"excerpt":{"rendered":"

on October 8, 2018 Pyruvate (PYR) dehydrogenase complex (PDC) is an enzymatic system that plays a crucial role in cellular metabolism as it controls the entry of carbon into the Krebs cycle. Recent experimental investigations highlighted its important role in cancer metabolism and indicated it as a potential target for the development of new anticancer […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-7764","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"\nNew paper from the Cavalli Lab - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-from-the-cavalli-lab-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper from the Cavalli Lab - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on October 8, 2018 Pyruvate (PYR) dehydrogenase complex (PDC) is an enzymatic system that plays a crucial role in cellular metabolism as it controls the entry of carbon into the Krebs cycle. 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