{"id":7715,"date":"2016-05-04T00:00:00","date_gmt":"2016-05-03T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports\/"},"modified":"2016-05-04T00:00:00","modified_gmt":"2016-05-03T22:00:00","slug":"new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports\/","title":{"rendered":"New paper on epigenetic regulation of gene expression by the lab of Silvia Monticelli published in Cell Reports"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">May 4, 2016<\/span><\/p>\n<p class=\"rtejustify\">A new article published in Cell Reports describes how an enzyme involved in regulating DNA demethylation processes impacts differentiation and proliferation of mast cells. TET2 is an enzyme involved in the regulation of DNA methylation dynamics that is frequently found mutated in myeloid malignancies such as systemic mastocytosis. This study, mainly performed by a PhD student, Sara Montagner, uncovers transcriptional pathways regulated by TET2 and identifies both enzymatic activity-dependent and -independent functions of TET2, shedding new light on potential mechanisms underlying the malignant transformation of mast cells.&nbsp;<\/p>\n<p class=\"rtejustify\"><img alt=\"\" src=\"\/images\/cell_article_news_silvia_may2016.jpg\" style=\"width: 257px; height: 198px; margin-right: 20px; float: left;\"><\/p>\n<p class=\"rtejustify\">This study was made possible by the help of outstanding collaborators, by funding from the Swiss National Science Foundation (SNSF) and the San Salvatore Foundation, and by contributions from the Novartis Foundation and the Ceresio Foundation. Sara is now continuing her studies in the same lab thanks to the support of a Marie Heim-V\u00f6gtlin (MHV) fellowship.<\/p>\n<p class=\"rtejustify\">&nbsp;<\/p>\n<p class=\"rtejustify\">&nbsp;<\/p>\n<p class=\"rtejustify\">&nbsp;<\/p>\n<p class=\"rtejustify\"><strong>Article:<\/strong><\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27160912\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.<\/strong><\/a><\/p>\n<p>Montagner, S., C. Leoni, S. Emming, G. Della Chiara, C. Balestrieri, I. Barozzi, V. Piccolo, S. Togher, M. Ko, A. Rao, G. Natoli and S. Monticelli<\/p>\n<p class=\"rtejustify\">Cell Rep. 2016; 15:1566-1579.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>on May 4, 2016 A new article published in Cell Reports describes how an enzyme involved in regulating DNA demethylation processes impacts differentiation and proliferation of mast cells. TET2 is an enzyme involved in the regulation of DNA methylation dynamics that is frequently found mutated in myeloid malignancies such as systemic mastocytosis. This study, mainly [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New paper on epigenetic regulation of gene expression by the lab of Silvia Monticelli published in Cell Reports - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper on epigenetic regulation of gene expression by the lab of Silvia Monticelli published in Cell Reports - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on May 4, 2016 A new article published in Cell Reports describes how an enzyme involved in regulating DNA demethylation processes impacts differentiation and proliferation of mast cells. TET2 is an enzyme involved in the regulation of DNA methylation dynamics that is frequently found mutated in myeloid malignancies such as systemic mastocytosis. This study, mainly [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2016-05-03T22:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/cell_article_news_silvia_may2016.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"1 minuto\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports\/#primaryimage\",\"inLanguage\":\"it-IT\",\"url\":\"\/images\/cell_article_news_silvia_may2016.jpg\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-on-epigenetic-regulation-of-gene-expression-by-the-lab-of-silvia-monticelli-published-in-cell-reports\/\",\"name\":\"New paper on epigenetic regulation of gene expression by the lab of Silvia Monticelli published in Cell Reports - 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