{"id":7680,"date":"2019-11-21T00:00:00","date_gmt":"2019-11-20T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/"},"modified":"2020-07-15T15:20:26","modified_gmt":"2020-07-15T13:20:26","slug":"new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/","title":{"rendered":"New Tool to Characterize the Dynamic Behaviour of Immune Cells"},"content":{"rendered":"

on November 21, 2019<\/span><\/p>\n

To analyse the complex dynamics of immune cells in response to an insult, an interdisciplinary effort is required. In a paper published this week in the journal Frontiers in Immunology<\/em>, the group of Santiago Gonz\u00e1lez at the IRB Bellinzona has characterized in vivo<\/em> the dynamic behavior of neutrophils in the popliteal lymph node after influenza vaccination. To achieve this, they have employed an image-based systems biology approach, which detects the motility patterns of neutrophils and associates them to distinct actions. This approach combined different imaging methodologies, molecular techniques, and pattern recognition methods, which allow them to identify and characterize distinct behaviors of neutrophils in response to influenza vaccination.<\/p>\n

This method will be very useful to understand the dynamic behavior of immune cells, and it has been currently applied to the characterization of immune cell dynamics in different experimental conditions such as immunotherapies or respiratory diseases.<\/p>\n

This work is part of a large project aiming at generating new tools based on computational methods to extract knowledge from imaging data. To this end, an interdisciplinary research team from the IRB and from the Institute of Computational Science (ICS), led by Santiago Gonz\u00e1lez and Rolf Krause, is developing innovative tools that will help to understand the complexity of the immune response using a state-of\u2013the-art imaging database.<\/p>\n\n\n\n\n\n\n
\"\"<\/td>\n<\/tr>\n
Neutrophil recruitment in the draining lymph node after influenza vaccination<\/td>\n<\/tr>\n
\"\"<\/td>\n<\/tr>\n
The development of new computational methods allows the visualization and better analysis of cell immune cell activities<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This work was possible thanks to funding from the Swiss National Science Foundation and SystemsX.ch, the Swiss initiative in Systems Biology.<\/p>\n

 <\/p>\n

Article<\/strong><\/p>\n

Characterization of the Dynamic Behavior of Neutrophils Following Influenza Vaccination<\/a><\/p>\n

Diego Ulisse Pizzagalli1, Irene Latino, Alain Pulfer, Miguel Palomino-Segura, Tommaso Virgilio, Yagmur Farsakoglu, Rolf Krause, and Santiago F. Gonzalez<\/p>\n

Front. Immunol., doi: 10.3389\/fimmu.2019.02621<\/p>\n","protected":false},"excerpt":{"rendered":"

on November 21, 2019 To analyse the complex dynamics of immune cells in response to an insult, an interdisciplinary effort is required. In a paper published this week in the journal Frontiers in Immunology, the group of Santiago Gonz\u00e1lez at the IRB Bellinzona has characterized in vivo the dynamic behavior of neutrophils in the popliteal […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"\nNew Tool to Characterize the Dynamic Behaviour of Immune Cells - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Tool to Characterize the Dynamic Behaviour of Immune Cells - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on November 21, 2019 To analyse the complex dynamics of immune cells in response to an insult, an interdisciplinary effort is required. In a paper published this week in the journal Frontiers in Immunology, the group of Santiago Gonz\u00e1lez at the IRB Bellinzona has characterized in vivo the dynamic behavior of neutrophils in the popliteal […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-20T22:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-15T13:20:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/front_immunol_sfg_dec2019_fig1.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"2 minuti\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/#primaryimage\",\"inLanguage\":\"it-IT\",\"url\":\"\/images\/front_immunol_sfg_dec2019_fig1.jpg\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/\",\"name\":\"New Tool to Characterize the Dynamic Behaviour of Immune Cells - IRB USI\",\"isPartOf\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/#primaryimage\"},\"datePublished\":\"2019-11-20T22:00:00+00:00\",\"dateModified\":\"2020-07-15T13:20:26+00:00\",\"author\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\"},\"breadcrumb\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"url\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"name\":\"News\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-tool-to-characterize-the-dynamic-behaviour-of-immune-cells-2\/\",\"name\":\"New Tool to Characterize the Dynamic Behaviour of Immune Cells\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\",\"name\":\"AD_Dave\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7680"}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=7680"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7680\/revisions"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=7680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=7680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=7680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}