{"id":7667,"date":"2010-01-01T00:00:00","date_gmt":"2009-12-31T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/nature-2009-highlights-includes-sallusto-ms-research\/"},"modified":"2010-01-01T00:00:00","modified_gmt":"2009-12-31T22:00:00","slug":"nature-2009-highlights-includes-sallusto-ms-research","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/","title":{"rendered":"Nature 2009 Highlights includes Sallusto MS Research"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">January 1, 2010<\/span><\/p>\n<p>\n\t<em><strong>Breaking into the brain<\/strong><\/em><\/p>\n<p>\n\tNature Immunol. 10, 514\u2013523 (2009)<\/p>\n<p>\n\t<strong>was seleceted by Nature as a highlight of 2009.<\/strong><\/p>\n<p>\n\tImmune cells can normally penetrate the barrier between the bloodstream and the brain only when the cells along this barrier are inflamed. So how do immune cells enter the brain to initiate the sort of inflammation associated with autoimmune disorders such as multiple sclerosis?<\/p>\n<p>\n\tFederica Sallusto of the Institute for Research in Biomedicine, Bellinzona, Switzerland, and her colleagues showed that the cells enter through the choroid plexus, the brain region where cerebrospinal fluid is made. They used a mouse model of multiple sclerosis to show that a subset of T cells gains entry when their CCR6 surface receptors bind to a protein produced by cells of the choroid plexus. Once inside, the immune cells initiate inflammation. The team also found that this gateway protein is present in the human choroid plexus and that a higher number of T cells from the spinal fluid of patients with multiple sclerosis express the CCR6 receptor.<\/p>\n<p>\n\t<strong><img alt=\"\" src=\"\/images\/news-cover-nature.jpg\" style=\"width: 150px; height: 197px\"><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>on January 1, 2010 Breaking into the brain Nature Immunol. 10, 514\u2013523 (2009) was seleceted by Nature as a highlight of 2009. Immune cells can normally penetrate the barrier between the bloodstream and the brain only when the cells along this barrier are inflamed. So how do immune cells enter the brain to initiate the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nature 2009 Highlights includes Sallusto MS Research - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nature 2009 Highlights includes Sallusto MS Research - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on January 1, 2010 Breaking into the brain Nature Immunol. 10, 514\u2013523 (2009) was seleceted by Nature as a highlight of 2009. Immune cells can normally penetrate the barrier between the bloodstream and the brain only when the cells along this barrier are inflamed. So how do immune cells enter the brain to initiate the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2009-12-31T22:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/news-cover-nature.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"1 minuto\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/#primaryimage\",\"inLanguage\":\"it-IT\",\"url\":\"\/images\/news-cover-nature.jpg\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/\",\"name\":\"Nature 2009 Highlights includes Sallusto MS Research - IRB USI\",\"isPartOf\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/#primaryimage\"},\"datePublished\":\"2009-12-31T22:00:00+00:00\",\"dateModified\":\"2009-12-31T22:00:00+00:00\",\"author\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\"},\"breadcrumb\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"url\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"name\":\"News\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/nature-2009-highlights-includes-sallusto-ms-research\/\",\"name\":\"Nature 2009 Highlights includes Sallusto MS Research\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\",\"name\":\"AD_Dave\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7667"}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=7667"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7667\/revisions"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=7667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=7667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=7667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}