{"id":7583,"date":"2009-07-08T00:00:00","date_gmt":"2009-07-07T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/nature-immunology-article-skin-homeostasis-and-inflammation\/"},"modified":"2009-07-08T00:00:00","modified_gmt":"2009-07-07T22:00:00","slug":"nature-immunology-article-skin-homeostasis-and-inflammation","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/nature-immunology-article-skin-homeostasis-and-inflammation\/","title":{"rendered":"Nature Immunology Article: skin homeostasis and inflammation"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">July 8, 2009<\/span><\/p>\n<p>\n\tProduction of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells<\/p>\n<p>\n\tNature Immunology<br \/>\n\tPublished online: 5 July 2009<\/p>\n<p>\n\tThomas Duhen, Rebekka Geiger, David Jarrossay, Antonio Lanzavecchia, Federica Sallusto<\/p>\n<p>\tAbstract<\/p>\n<p>\n\tInterleukin 22 (IL-22) is a cytokine produced by the TH-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4+ T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon- (IFN-). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the TH-17 and T helper type 1 (TH1) transcription factors RORt and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor\u2013dependent way. Our findings delineate a previously unknown subset of human CD4+ effector T cells dedicated to skin pathophysiology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>on July 8, 2009 Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells Nature Immunology Published online: 5 July 2009 Thomas Duhen, Rebekka Geiger, David Jarrossay, Antonio Lanzavecchia, Federica Sallusto Abstract Interleukin 22 (IL-22) is a cytokine produced by the TH-17 lineage of helper T cells and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-7583","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nature Immunology Article: skin homeostasis and inflammation - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/nature-immunology-article-skin-homeostasis-and-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nature Immunology Article: skin homeostasis and inflammation - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on July 8, 2009 Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells Nature Immunology Published online: 5 July 2009 Thomas Duhen, Rebekka Geiger, David Jarrossay, Antonio Lanzavecchia, Federica Sallusto Abstract Interleukin 22 (IL-22) is a cytokine produced by the TH-17 lineage of helper T cells and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/nature-immunology-article-skin-homeostasis-and-inflammation\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2009-07-07T22:00:00+00:00\" \/>\n<meta name=\"author\" content=\"AD_Dave\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"AD_Dave\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/nature-immunology-article-skin-homeostasis-and-inflammation\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/nature-immunology-article-skin-homeostasis-and-inflammation\\\/\"},\"author\":{\"name\":\"AD_Dave\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/person\\\/c9b66c69925e1b0c558072acbadf4156\"},\"headline\":\"Nature Immunology Article: skin homeostasis and inflammation\",\"datePublished\":\"2009-07-07T22:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/nature-immunology-article-skin-homeostasis-and-inflammation\\\/\"},\"wordCount\":180,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#organization\"},\"articleSection\":[\"News\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/nature-immunology-article-skin-homeostasis-and-inflammation\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/nature-immunology-article-skin-homeostasis-and-inflammation\\\/\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/nature-immunology-article-skin-homeostasis-and-inflammation\\\/\",\"name\":\"Nature Immunology Article: skin homeostasis and inflammation - 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