{"id":7558,"date":"2019-02-27T00:00:00","date_gmt":"2019-02-26T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/new-paper-from-the-gonzalez-lab-3\/"},"modified":"2019-02-27T00:00:00","modified_gmt":"2019-02-26T22:00:00","slug":"new-paper-from-the-gonzalez-lab-3","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-paper-from-the-gonzalez-lab-3\/","title":{"rendered":"New paper from the Gonz\u00e1lez Lab"},"content":{"rendered":"

on<\/span> February 27, 2019<\/span><\/p>\n

The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. This study, published in Cell Reports,<\/em> determined the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN).<\/p>\n

In this study, Farsakoglu et. al. found that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leaded to their early production of IFN\u03b3, which in turn regulated the recruitment of IL-6+ CD11b+ dendritic cells. Finally, this study demonstrated that the interleukin-6 (IL-6)-mediated inflammation was important for the development of an effective humoral response against influenza virus in the draining LN.<\/p>\n\n\n\n\n
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At early times following influenza vaccination, NK cells are recruited to the draining lymph node were they are activated by the type I IFN produced by necrotic lymph node macrophages. In response, NK cells produce IFN\u03b3 that promotes the recruitment of IL6+ lymph node dendritic cells. Early production of IL-6 positively regulate anti-influenza B cell responses.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Article:<\/strong><\/p>\n

Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner<\/a><\/p>\n

Y. Farsakoglu, M. Palomino-Segura, I. Latino, S. Zanaga, N. Chatziandreou, D. U. Pizzagalli, A. Rinaldi, M. Bolis, F. Sallusto, J. V. Stein, S. F. Gonzalez<\/p>\n

in Cell Rep<\/em> (2019) vol. 26 pp2307-2315 e5<\/p>\n","protected":false},"excerpt":{"rendered":"

on February 27, 2019 The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. This study, published in Cell Reports, determined the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). In this […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"\nNew paper from the Gonz\u00e1lez Lab - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-from-the-gonzalez-lab-3\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper from the Gonz\u00e1lez Lab - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on February 27, 2019 The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. This study, published in Cell Reports, determined the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). 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