{"id":7527,"date":"2017-03-15T00:00:00","date_gmt":"2017-03-14T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/new-paper-by-the-gonzalez-lab\/"},"modified":"2017-03-15T00:00:00","modified_gmt":"2017-03-14T22:00:00","slug":"new-paper-by-the-gonzalez-lab","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/","title":{"rendered":"New paper by the Gonz\u00e1lez Lab"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">March 15, 2017<\/span><\/p>\n<p class=\"rtejustify\">The inflammatory process initiated in the lymph node after vaccine administration is crucial to develop a protective response against the pathogen. In this work, we describe the mechanism by which one of the most relevant cells involved in the inflammatory process, the lymph node macrophages, initiate this response. These cells die quickly after vaccine administration, and their death promote the release of different molecules, which act as an alarm signal and activate other immune cells. The description of this pathway will open new possibilities to improve vaccine efficiency.<\/p>\n<p><img alt=\"\" src=\"\/images\/3dreconstruction_popln_santiago_paper_cell_report.jpg\" style=\"width: 500px; height: 415px; float: left; margin-right: 20px\">3D reconstruction of a whole popliteal lymph node by 2-photon microscopy; in the picture are showed the Subcapsular Sinus Macrophages (yellow), Medullary macrophages (red), B cells follicles (blue) and transgenic CX3CR1 (green).<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Article<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28273457\" target=\"_blank\" rel=\"noopener noreferrer\">Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node<\/a><br \/>\nN. Chatziandreou, Y. Farsakoglu, M. Palomino-Segura, R. D&#8217;Antuono, D. U. Pizzagalli, F. Sallusto, V. Lukacs-Kornek, M. Uguccioni, D. Corti, S. J. Turley, A. Lanzavecchia, M. C. Carroll, S. F. Gonzalez<br \/>\nin Cell Rep (2017) vol. 18 pp2427-2440<\/p>\n","protected":false},"excerpt":{"rendered":"<p>on March 15, 2017 The inflammatory process initiated in the lymph node after vaccine administration is crucial to develop a protective response against the pathogen. In this work, we describe the mechanism by which one of the most relevant cells involved in the inflammatory process, the lymph node macrophages, initiate this response. These cells die [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New paper by the Gonz\u00e1lez Lab - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper by the Gonz\u00e1lez Lab - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on March 15, 2017 The inflammatory process initiated in the lymph node after vaccine administration is crucial to develop a protective response against the pathogen. In this work, we describe the mechanism by which one of the most relevant cells involved in the inflammatory process, the lymph node macrophages, initiate this response. These cells die [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2017-03-14T22:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/3dreconstruction_popln_santiago_paper_cell_report.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"1 minuto\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/#primaryimage\",\"inLanguage\":\"it-IT\",\"url\":\"\/images\/3dreconstruction_popln_santiago_paper_cell_report.jpg\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/\",\"name\":\"New paper by the Gonz\\u00e1lez Lab - IRB USI\",\"isPartOf\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/#primaryimage\"},\"datePublished\":\"2017-03-14T22:00:00+00:00\",\"dateModified\":\"2017-03-14T22:00:00+00:00\",\"author\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\"},\"breadcrumb\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"url\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"name\":\"News\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-by-the-gonzalez-lab\/\",\"name\":\"New paper by the Gonz\\u00e1lez Lab\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156\",\"name\":\"AD_Dave\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7527"}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=7527"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/7527\/revisions"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=7527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=7527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=7527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}