{"id":7519,"date":"2019-04-02T00:00:00","date_gmt":"2019-04-01T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/new-paper-from-the-guarda-lab\/"},"modified":"2019-04-02T00:00:00","modified_gmt":"2019-04-01T22:00:00","slug":"new-paper-from-the-guarda-lab","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-paper-from-the-guarda-lab\/","title":{"rendered":"New paper from the Guarda Lab"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">April 2, 2019<\/span><\/p>\n<p class=\"rtejustify\">The phosphatase Shp-2 has been suggested to regulate signaling downstream of NK cell inhibitory receptors, which are essential to calibrate NK cell responsiveness; however, our genetic approaches did not support this hypothesis. Intriguingly, Shp-2 has been shown to positively regulate ERK (extracellular signal-regulated kinase) activation in various tissues. We thus investigated this possibility in NK cells and identified an essential role for Shp-2 in engaging this cascade and raising cellular metabolism in response to interleukin-15, a key cytokine for NK cell development and function. Together, these data reveal a positive role for Shp-2 in regulating NK lymphocytes\u2019 cytokine responses and suggest Shp-2 inhibition to be beneficial in selected malignancies originating from these cell types.<\/p>\n<p class=\"rtejustify\"><img loading=\"lazy\" alt=\"\" height=\"302\" src=\"\/images\/paper_nature_com_guarda_march2019.jpg\" width=\"362\"><\/p>\n<p><strong>Article<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30926899\" target=\"_blank\" rel=\"noopener noreferrer\">Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells<\/a><br \/>\nC. Niogret, S. M. S. Miah, G. Rota, N. P. Fonta, H. Wang, W. Held, W. Birchmeier, V. Sexl, W. Yang, E. Vivier, P. C. Ho, L. Brossay, G. Guarda<br \/>\nin Nat Commun (2019) vol. 10 pp1444.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>on April 2, 2019 The phosphatase Shp-2 has been suggested to regulate signaling downstream of NK cell inhibitory receptors, which are essential to calibrate NK cell responsiveness; however, our genetic approaches did not support this hypothesis. Intriguingly, Shp-2 has been shown to positively regulate ERK (extracellular signal-regulated kinase) activation in various tissues. We thus investigated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New paper from the Guarda Lab - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-from-the-guarda-lab\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper from the Guarda Lab - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on April 2, 2019 The phosphatase Shp-2 has been suggested to regulate signaling downstream of NK cell inhibitory receptors, which are essential to calibrate NK cell responsiveness; however, our genetic approaches did not support this hypothesis. Intriguingly, Shp-2 has been shown to positively regulate ERK (extracellular signal-regulated kinase) activation in various tissues. 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