{"id":7372,"date":"2007-10-08T00:00:00","date_gmt":"2007-10-07T22:00:00","guid":{"rendered":"https:\/\/irb.usi.ch\/uncategorized\/nature-immunology-article-markus-manz-2\/"},"modified":"2007-10-08T00:00:00","modified_gmt":"2007-10-07T22:00:00","slug":"nature-immunology-article-markus-manz-2","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/nature-immunology-article-markus-manz-2\/","title":{"rendered":"Nature Immunology Article: Markus Manz"},"content":{"rendered":"<p class=\"news-publication\"><span>on<\/span> <span class=\"date-display-single\">October 8, 2007<\/span><\/p>\n<p>\n\t<img alt=\"\" src=\"\/images\/news-markus-manz.png\" style=\"width: 220px; height: 284px\"><\/p>\n<p>\n\tThe October issue of Nature Immunology includes an article from the lab of Markus Manz on&nbsp;the Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse&nbsp;bone marrow.<\/p>\n<p>\n\tAbstract:<br \/>\n\tLymphoid tissue plasmacytoid and conventional dendritic cells (DCs) are continuously regenerated from hematopoietic stem&nbsp;cells. The cytokine dependence and biology of plasmacytoid and conventional DCs suggest that regeneration might proceed through common DC-restricted developmental intermediates. By selecting for cytokine receptor expression relevant to DC development, we identify here highly cycling Lin\u2013c-KitintFlt3+M-CSFR+ cells with a distinct gene-expression profile in mouse&nbsp;bone marrow that, on a clonal level in vitro and as a population both in vitro and in vivo, efficiently generated plasmacytoid and&nbsp;conventional DCs but no other lineages, which increased in number after in vivo injection of the cytokine Flt3 ligand. These&nbsp;clonogenic common DC progenitors thus define a cytokine-regulated DC developmental pathway that ensures the supply of&nbsp;various DC populations.<\/p>\n<p>\n\t<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17922016\" target=\"_blank\" rel=\"noopener noreferrer\">Pubmed<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>on October 8, 2007 The October issue of Nature Immunology includes an article from the lab of Markus Manz on&nbsp;the Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse&nbsp;bone marrow. Abstract: Lymphoid tissue plasmacytoid and conventional dendritic cells (DCs) are continuously regenerated from hematopoietic stem&nbsp;cells. The cytokine dependence and biology of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nature Immunology Article: Markus Manz - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/nature-immunology-article-markus-manz-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nature Immunology Article: Markus Manz - IRB USI\" \/>\n<meta property=\"og:description\" content=\"on October 8, 2007 The October issue of Nature Immunology includes an article from the lab of Markus Manz on&nbsp;the Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse&nbsp;bone marrow. Abstract: Lymphoid tissue plasmacytoid and conventional dendritic cells (DCs) are continuously regenerated from hematopoietic stem&nbsp;cells. 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