{"id":43407,"date":"2026-10-23T09:14:42","date_gmt":"2026-10-23T07:14:42","guid":{"rendered":"https:\/\/irb.usi.ch\/irb-community\/irb-researcher-veronica-martini-awarded-a-bridge-proof-of-concept-grant\/"},"modified":"2026-10-23T09:19:14","modified_gmt":"2026-10-23T07:19:14","slug":"irb-researcher-veronica-martini-awarded-a-bridge-proof-of-concept-grant","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/home-slider-it\/irb-researcher-veronica-martini-awarded-a-bridge-proof-of-concept-grant\/","title":{"rendered":"Alla ricercatrice IRB Veronica Martini un finanziamento BRIDGE Proof of Concept"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"43407\" class=\"elementor elementor-43407 elementor-43399\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-837728b elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"837728b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5c3b340 ae-bg-gallery-type-default\" data-id=\"5c3b340\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a492c2 elementor-widget elementor-widget-text-editor\" data-id=\"6a492c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Veronica Martini, ricercatrice presso l\u2019Istituto di Ricerca in Biomedicina (IRB) di Bellinzona, affiliato all\u2019Universit\u00e0 della Svizzera italiana (USI), ha ottenuto un finanziamento BRIDGE Proof of Concept per sviluppare una nuova classe di inibitori di CXCR2. Il progetto esplora una strategia innovativa per agire sui neutrofili associati ai tumori e studiare nuovi approcci terapeutici contro il cancro al seno.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-00d17fc elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"00d17fc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0e0e214 ae-bg-gallery-type-default\" data-id=\"0e0e214\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f789f86 elementor-widget elementor-widget-text-editor\" data-id=\"f789f86\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I neutrofili sono i globuli bianchi pi\u00f9 numerosi nel sangue e svolgono un ruolo fondamentale nella difesa dell&#8217;organismo dalle infezioni. Studi recenti hanno per\u00f2 dimostrato che, in alcuni tumori, possono acquisire caratteristiche che favoriscono la progressione della malattia, sopprimendo la risposta immunitaria e contribuendo alla crescita e alla diffusione del cancro.<\/p><p>Il loro reclutamento nei tumori dipende in larga misura da CXCR2, un recettore presente sulla loro superficie. Sebbene siano gi\u00e0 stati sperimentati farmaci in grado di bloccarlo, i composti attualmente disponibili agiscono soltanto in modo temporaneo.<\/p><p>Grazie al finanziamento BRIDGE Proof of Concept, la ricercatrice IRB Veronica Martini intende sviluppare una nuova classe di inibitori capaci di legarsi stabilmente a CXCR2. Questa strategia potrebbe garantire un&#8217;azione pi\u00f9 duratura sui neutrofili associati ai tumori, preservando al contempo le funzioni del recettore CXCR1, coinvolto nella difesa dalle infezioni.<\/p><p>\u00a0<\/p><p>Nel corso di un anno, il progetto si concentrer\u00e0 su BP-4, un composto sperimentale sviluppato per bloccare il recettore CXCR2 e potenzialmente impedire ai neutrofili di contribuire alla progressione tumorale. I ricercatori ne valuteranno la stabilit\u00e0, il comportamento in vivo e la capacit\u00e0 di raggiungere il proprio bersaglio. Successivamente, studieranno la sua capacit\u00e0 di rallentare la crescita del tumore in modelli preclinici di cancro al seno, sia da solo sia in combinazione con l&#8217;immunoterapia.<\/p><p>Il progetto rappresenta un primo passo verso lo sviluppo di una possibile nuova strategia terapeutica contro il cancro al seno.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Veronica Martini, ricercatrice presso l\u2019Istituto di Ricerca in Biomedicina (IRB) di Bellinzona, affiliato all\u2019Universit\u00e0 della Svizzera italiana (USI), ha ottenuto un finanziamento BRIDGE Proof of Concept per sviluppare una nuova classe di inibitori di CXCR2. Il progetto esplora una strategia innovativa per agire sui neutrofili associati ai tumori e studiare nuovi approcci terapeutici contro il [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":43398,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[53,75],"tags":[],"class_list":["post-43407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home-slider-it","category-news-it"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alla ricercatrice IRB Veronica Martini un finanziamento BRIDGE Proof of Concept - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/home-slider-it\/irb-researcher-veronica-martini-awarded-a-bridge-proof-of-concept-grant\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alla ricercatrice IRB Veronica Martini un finanziamento BRIDGE Proof of Concept - IRB USI\" \/>\n<meta property=\"og:description\" content=\"Veronica Martini, ricercatrice presso l\u2019Istituto di Ricerca in Biomedicina (IRB) di Bellinzona, affiliato all\u2019Universit\u00e0 della Svizzera italiana (USI), ha ottenuto un finanziamento BRIDGE Proof of Concept per sviluppare una nuova classe di inibitori di CXCR2. 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