{"id":35168,"date":"2024-03-21T17:17:08","date_gmt":"2024-03-21T15:17:08","guid":{"rendered":"https:\/\/irb.usi.ch\/?p=35168"},"modified":"2024-03-21T17:24:28","modified_gmt":"2024-03-21T15:24:28","slug":"new-insight-into-sensing-and-function-of-the-bacterial-lysate-om-85","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-insight-into-sensing-and-function-of-the-bacterial-lysate-om-85\/","title":{"rendered":"New insight into sensing and function of the bacterial lysate OM-85"},"content":{"rendered":"<p><strong>Bacterial lysates are widely used in the clinic to minimize the pathologic consequences of respiratory infections. Our new study shows how one such lysate, OM-85, works on human myeloid cells to trigger an immunomodulatory gene circuit.<\/strong><\/p>\n<p>Bellinzona, March 21, 2024 &#8211;\u00a0OM-85 is a bacterial lysate commonly used in clinical practice to reduce duration and frequency of recurrent respiratory tract infections. Whereas some studies have addressed its regulatory effects <em>in vivo<\/em>, the mechanisms of OM-85 sensing remain inadequately investigated. In a new study recently published in <em>Mucosal Immunology<\/em>, led by prof. Greta Guarda at the Institute for Research in Biomedicine (IRB, affiliated to the Universit\u00e0 della Svizzera italiana), in collaboration with OM-Pharma (Meyrin, Switzerland), Dr. med. Maurizio Bernasconi at Ente Ospedalierio Cantonale (EOC), and Oncolines (Netherlands), the researchers investigated the mechanisms of OM-85 sensing and function in the immune cells.<\/p>\n<p>Dr. Hanif Khameneh and colleagues showed that, in human immune cells, TLR2 and TLR4 orchestrate the response to OM-85. RNA-sequencing on human monocyte-derived dendritic cells as well as single cell RNAseq on human bronchoalveolar lavage cells revealed a largely overlapping TLR2\/4-dependent proinflammatory gene signature induced by OM-85, including a unique immunomodulatory gene set. The findings of this study reveal how a standardized bacterial lysate fine-tunes the immune response through TLR2 and TLR4, which are crucial for immunity and tolerance.<\/p>\n<p><em><a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2024.02.010\">Link to the scientific article<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bacterial lysates are widely used in the clinic to minimize the pathologic consequences of respiratory infections. Our new study shows how one such lysate, OM-85, works on human myeloid cells to trigger an immunomodulatory gene circuit. Bellinzona, March 21, 2024 &#8211;\u00a0OM-85 is a bacterial lysate commonly used in clinical practice to reduce duration and frequency [&hellip;]<\/p>\n","protected":false},"author":136,"featured_media":35172,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-35168","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New insight into sensing and function of the bacterial lysate OM-85 - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-insight-into-sensing-and-function-of-the-bacterial-lysate-om-85\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New insight into sensing and function of the bacterial lysate OM-85 - IRB USI\" \/>\n<meta property=\"og:description\" content=\"Bacterial lysates are widely used in the clinic to minimize the pathologic consequences of respiratory infections. Our new study shows how one such lysate, OM-85, works on human myeloid cells to trigger an immunomodulatory gene circuit. 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