{"id":28199,"date":"2022-08-12T17:09:27","date_gmt":"2022-08-12T15:09:27","guid":{"rendered":"https:\/\/irb.usi.ch\/?p=28199"},"modified":"2022-08-12T17:11:38","modified_gmt":"2022-08-12T15:11:38","slug":"imaging-dna-repair-complexes-in-action","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/imaging-dna-repair-complexes-in-action\/","title":{"rendered":"Imaging DNA repair complexes in action"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"28199\" class=\"elementor elementor-28199\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-c6e4fa4 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"c6e4fa4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e2a8f10 ae-bg-gallery-type-default\" data-id=\"e2a8f10\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f2d0b2c elementor-widget elementor-widget-text-editor\" data-id=\"f2d0b2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The Mre11-Rad50 nuclease complex has important functions to initiate the repair of broken DNA. A collaborative study of the Cejka (IRB Bellinzona) and Peter laboratories (ETH Zurich) took a new approach to image the DNA repair proteins in action.<\/p><p>The researchers used a technique termed transmission electron microscopy, which allowed to visualize broken DNA, and the repair proteins, including Mre11-Rad50 and Sae2, that act on the DNA molecules. The key observation of the study was that the proteins form large assemblies that include multiple subunits. It is thought that these proteins load on DNA bound together. This allows them to initiate the repair process by acting on the broken DNA at many sites at the same time.<\/p><p>Although the study employed proteins from the yeast model organism <em>S. cerevisiae<\/em>, the proteins are though to function very similarly also in human cells. In fact, the region of the Rad50 protein that was found to be required for the multiprotein assembly is often mutated in human cancers, suggesting that the formation of the protein complex is a necessary for proper DNA repair and cancer avoidance.<\/p><p>Vera Kissling, jointly supervised by the Cejka and Peter laboratories, performed most of the experiments described in the publication, together with Giordano Reginato (IRB Bellinzona) and Eliana Bianco (ETH Zurich). The research was funded by a grant from the Helmut Horten Foundation.<\/p><p><strong>Article<\/strong><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35501303\/\" target=\"_blank\" rel=\"noopener\">Mre11-Rad50 oligomerization promotes DNA double-strand break repair.<\/a><\/p><p>Kissling, V. M., G. Reginato, E. Bianco, K. Kasaciunaite, J. Tilma, G. Cereghetti, N. Schindler, S. S. Lee, R. Guerois, B. Luke, R. Seidel, P. Cejka and M. Peter<\/p><p>Nat Commun. 2022; 13:2374.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-a0f5139 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"a0f5139\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-37993f2 ae-bg-gallery-type-default\" data-id=\"37993f2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a0a126 elementor-widget elementor-widget-image\" data-id=\"7a0a126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/irb.usi.ch\/images\/Nature_Com_Petr_Cejka_May2022.jpg\" class=\"attachment-large size-large wp-image-28202\" alt=\"\" srcset=\"https:\/\/irb.usi.ch\/images\/Nature_Com_Petr_Cejka_May2022.jpg 1024w, https:\/\/irb.usi.ch\/images\/Nature_Com_Petr_Cejka_May2022-300x169.jpg 300w, https:\/\/irb.usi.ch\/images\/Nature_Com_Petr_Cejka_May2022-768x432.jpg 768w, https:\/\/irb.usi.ch\/images\/Nature_Com_Petr_Cejka_May2022-750x422.jpg 750w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-0e566d9 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"0e566d9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eb8d4d9 ae-bg-gallery-type-default\" data-id=\"eb8d4d9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ebf45f7 elementor-widget elementor-widget-text-editor\" data-id=\"ebf45f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span dir=\"ltr\" role=\"presentation\">Transmission electron microscopy of Mre11-Rad50 binding to plasmid DNA at 30 \u00b0C with co-factors.\u00a0<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">MR dimers oligomerizing on DNA and some MR molecules forming<\/span> <span dir=\"ltr\" role=\"presentation\">\u201c<\/span><span dir=\"ltr\" role=\"presentation\">pearls-on-a-string<\/span><span dir=\"ltr\" role=\"presentation\">\u201d<\/span><span dir=\"ltr\" role=\"presentation\">-like structures (zoom-insets of examples with cartoons),<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">irrespective of DNA ends.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The Mre11-Rad50 nuclease complex has important functions to initiate the repair of broken DNA. A collaborative study of the Cejka (IRB Bellinzona) and Peter laboratories (ETH Zurich) took a new approach to image the DNA repair proteins in action. The researchers used a technique termed transmission electron microscopy, which allowed to visualize broken DNA, and [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":28201,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-28199","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Imaging DNA repair complexes in action - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/imaging-dna-repair-complexes-in-action\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Imaging DNA repair complexes in action - IRB USI\" \/>\n<meta property=\"og:description\" content=\"The Mre11-Rad50 nuclease complex has important functions to initiate the repair of broken DNA. A collaborative study of the Cejka (IRB Bellinzona) and Peter laboratories (ETH Zurich) took a new approach to image the DNA repair proteins in action. The researchers used a technique termed transmission electron microscopy, which allowed to visualize broken DNA, and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/imaging-dna-repair-complexes-in-action\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2022-08-12T15:09:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-08-12T15:11:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/Nature_Com_Petr_Cejka_May2022.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"576\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Maryse\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Maryse\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/imaging-dna-repair-complexes-in-action\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/imaging-dna-repair-complexes-in-action\\\/\"},\"author\":{\"name\":\"Maryse\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/person\\\/1bdd6a1c070b712a183ecb2684c11bc8\"},\"headline\":\"Imaging DNA repair complexes in action\",\"datePublished\":\"2022-08-12T15:09:27+00:00\",\"dateModified\":\"2022-08-12T15:11:38+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/imaging-dna-repair-complexes-in-action\\\/\"},\"wordCount\":309,\"publisher\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/imaging-dna-repair-complexes-in-action\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/Nature_Com_Petr_Cejka_May2022.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/imaging-dna-repair-complexes-in-action\\\/\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/imaging-dna-repair-complexes-in-action\\\/\",\"name\":\"Imaging DNA repair complexes in action - 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