{"id":26565,"date":"2022-02-15T12:35:10","date_gmt":"2022-02-15T10:35:10","guid":{"rendered":"https:\/\/irb.usi.ch\/?p=26565"},"modified":"2022-03-07T17:05:45","modified_gmt":"2022-03-07T15:05:45","slug":"new-paper-published-in-plos-biology","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/","title":{"rendered":"New paper published in PLoS Biology"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"26565\" class=\"elementor elementor-26565\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-11695ae elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"11695ae\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6de4924 ae-bg-gallery-type-default\" data-id=\"6de4924\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4599b57 elementor-widget elementor-widget-text-editor\" data-id=\"4599b57\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\"><p>Bellinzona, February 15, 2022 &#8211; The proliferation and effector function of T lymphocytes of the immune system must be carefully regulated. These cells are indeed crucial sentinels that protect the body from invading pathogens, but their powerful responses must be limited in magnitude and duration to avoid damage to healthy tissues. A network of molecular mechanisms ensures that T cell responses are productive and at the same time restricted to reduce the risks of excessive inflammation. In this study, using an integrated approach involving quantitative analysis, unbiased genomics and genome editing, the group of <a href=\"https:\/\/irb.usi.ch\/irb-people\/monticelli-silvia\/\" target=\"_blank\" rel=\"noopener\">Silvia Monticelli<\/a> identified a microRNA-regulated network involved in restraining proliferative responses of circulating resting human T lymphocytes. MicroRNAs are small regulatory molecules that modulate all aspects of cell biology and have key functions within immune responses. This study, published in PLoS Biology, adds another piece to the puzzle of the regulation of T cell functions in humans.<\/p><p><strong>Article<\/strong><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35143476\/\">RFX transcription factors control a miR-150\/PDAP1 axis that restrains the proliferation of human T cells<\/a>.<\/p><p>Chirichella*, M., N. Bianchi*, E. Dzafo*, E. Foli, F. Gualdrini, A. Kenyon, G. Natoli and S. Monticelli<\/p><p>PLoS Biol. 2022; 20:e3001538.<\/p><p>*Joint first authors<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Bellinzona, February 15, 2022 &#8211; The proliferation and effector function of T lymphocytes of the immune system must be carefully regulated. These cells are indeed crucial sentinels that protect the body from invading pathogens, but their powerful responses must be limited in magnitude and duration to avoid damage to healthy tissues. A network of molecular [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":26575,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New paper published in PLoS Biology - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New paper published in PLoS Biology - IRB USI\" \/>\n<meta property=\"og:description\" content=\"Bellinzona, February 15, 2022 &#8211; The proliferation and effector function of T lymphocytes of the immune system must be carefully regulated. These cells are indeed crucial sentinels that protect the body from invading pathogens, but their powerful responses must be limited in magnitude and duration to avoid damage to healthy tissues. A network of molecular [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2022-02-15T10:35:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-03-07T15:05:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/Foto_PloSBiology_Chiricchela_Feb2022v3.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1023\" \/>\n\t<meta property=\"og:image:height\" content=\"576\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"1 minuto\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/#primaryimage\",\"inLanguage\":\"it-IT\",\"url\":\"https:\/\/irb.usi.ch\/images\/Foto_PloSBiology_Chiricchela_Feb2022v3.jpg\",\"width\":1023,\"height\":576},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/\",\"name\":\"New paper published in PLoS Biology - IRB USI\",\"isPartOf\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/#primaryimage\"},\"datePublished\":\"2022-02-15T10:35:10+00:00\",\"dateModified\":\"2022-03-07T15:05:45+00:00\",\"author\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/1bdd6a1c070b712a183ecb2684c11bc8\"},\"breadcrumb\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"url\":\"https:\/\/irb.usi.ch\/.\/news\/\",\"name\":\"News\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/news\/new-paper-published-in-plos-biology\/\",\"name\":\"New paper published in PLoS Biology\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/1bdd6a1c070b712a183ecb2684c11bc8\",\"name\":\"Maryse\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/26565"}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=26565"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/26565\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media\/26575"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=26565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=26565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=26565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}