{"id":26127,"date":"2021-12-02T17:04:44","date_gmt":"2021-12-02T15:04:44","guid":{"rendered":"https:\/\/irb.usi.ch\/?p=26127"},"modified":"2021-12-10T10:10:16","modified_gmt":"2021-12-10T08:10:16","slug":"interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\/","title":{"rendered":"Interplay of Dna2 and RPA in DNA metabolism, a Nature Communications paper"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"26127\" class=\"elementor elementor-26127\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-26c2e08 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"26c2e08\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fd71de4 ae-bg-gallery-type-default\" data-id=\"fd71de4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a4343b5 elementor-widget elementor-widget-text-editor\" data-id=\"a4343b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Bellinzona, December 2nd, 2021 &#8211; DNA end resection is required for accurate processing of broken DNA. In a paper published in Nature Communications, IRB researchers <a href=\"https:\/\/irb.usi.ch\/recombination-mechanisms\/\">Acharya, Cejka and colleagues<\/a> investigated the interplay of the Dna2 nuclease and the single strand DNA binding protein RPA in DNA end resection. RPA has a strong affinity to ssDNA, and often acts in DNA metabolism non-specifically to protect unwound DNA. In the resection process however, RPA plays a much more direct role, in fact, it stimulates Dna2 recruitment and its helicase and nuclease activities, which are important for DNA end resection. The authors define the various RPA domains involved in Dna2 regulation, and find that distinct RPA domains are involved in the regulation of the different Dna2 functions. The research stems from a collaboration between researchers from IRB Bellinzona, ETH Zurich, University of Leipzig (Germany) and CNRS (France).<\/p><p><strong>Article<\/strong><\/p><p><a href=\"https:\/\/www.nature.com\/articles\/s41467-021-26863-y\">Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2<\/a><\/p><p>Ananya Acharya, Kristina Kasaciunaite, Martin G\u00f6se, Vera Kissling, Rapha\u00ebl Gu\u00e9rois, Ralf Seidel &amp; Petr Cejka<\/p><p>Nature Communications (2021), 12: 6521<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Bellinzona, December 2nd, 2021 &#8211; DNA end resection is required for accurate processing of broken DNA. In a paper published in Nature Communications, IRB researchers Acharya, Cejka and colleagues investigated the interplay of the Dna2 nuclease and the single strand DNA binding protein RPA in DNA end resection. RPA has a strong affinity to ssDNA, [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":26128,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-26127","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Interplay of Dna2 and RPA in DNA metabolism, a Nature Communications paper - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interplay of Dna2 and RPA in DNA metabolism, a Nature Communications paper - IRB USI\" \/>\n<meta property=\"og:description\" content=\"Bellinzona, December 2nd, 2021 &#8211; DNA end resection is required for accurate processing of broken DNA. In a paper published in Nature Communications, IRB researchers Acharya, Cejka and colleagues investigated the interplay of the Dna2 nuclease and the single strand DNA binding protein RPA in DNA end resection. RPA has a strong affinity to ssDNA, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2021-12-02T15:04:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-12-10T08:10:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/Cejka_Nature_dec2021_slider.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"505\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Maryse\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Maryse\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\\\/\"},\"author\":{\"name\":\"Maryse\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/person\\\/1bdd6a1c070b712a183ecb2684c11bc8\"},\"headline\":\"Interplay of Dna2 and RPA in DNA metabolism, a Nature Communications paper\",\"datePublished\":\"2021-12-02T15:04:44+00:00\",\"dateModified\":\"2021-12-10T08:10:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\\\/\"},\"wordCount\":187,\"publisher\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/Cejka_Nature_dec2021_slider.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\\\/\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/interplay-of-dna2-and-rpa-in-dna-metabolism-a-nature-communications-paper\\\/\",\"name\":\"Interplay of Dna2 and RPA in DNA metabolism, a Nature Communications paper - 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