{"id":25584,"date":"2021-10-07T13:40:53","date_gmt":"2021-10-07T11:40:53","guid":{"rendered":"https:\/\/irb.usi.ch\/?p=25584"},"modified":"2021-10-07T13:52:58","modified_gmt":"2021-10-07T11:52:58","slug":"engineered-bacteria-for-cancer-immunotherapy","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/engineered-bacteria-for-cancer-immunotherapy\/","title":{"rendered":"Engineered bacteria for cancer immunotherapy"},"content":{"rendered":"\t\t
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Bellinzona, October 6th<\/sup>, 2021 \u2013 A Nature paper by the Systems Immunology <\/em>group<\/a>, headed by Roger Geiger<\/a>, at the Institute for Research in Biomedicine (IRB, affiliated to USI).<\/p>

This study describes an innovative strategy to improve the anti-tumor activity of T cells, key players of the immune system with the ability to detect and kill cancer cells.<\/p>

The discovery<\/strong><\/p>

Due to their increased metabolism, tumors accumulate numerous metabolites that influence their growth and modulate immune cells. One potential therapeutic intervention is to tune the concentrations of these metabolites in favor of an effective anti-tumor response. However, methods to locally control metabolite concentrations in tumors are challenging.<\/p>

Certain non-pathogenic bacterial strains colonize tumors and are able to survive and thrive in the necrotic core. In collaboration with Synlogic, Cambridge (USA), the group of Roger Geiger used a synthetic biology approach to develop an engineered probiotic Escherichia coli<\/em> strain that continuously converts ammonia, a metabolic waste product that accumulates in tumors, to L-arginine. L-arginine is an immunomodulatory metabolite that enhances anti-tumor functions of T cells.<\/p>

The engineered bacteria colonize tumors, increase intratumoral L-arginine, enhance T cell activity, and synergize with PD-L1 blocking antibodies. Thus, engineered microbial therapies enable metabolic modulation of tumors leading to enhanced efficacy of immunotherapies.<\/p>

This bacteria-based therapy is suitable for the development of human therapeutics. The non-pathogenic bacteria have an intrinsic \u201ckill-switch\u201d as they are susceptible to antibiotics and possess desirable engineerability, safety and manufacturability features. Intratumoral injections of probiotic bacteria were previously found safe in clinical studies.<\/p>

Article<\/strong><\/p>

Metabolic modulation of tumours with engineered bacteria for immunotherapy<\/strong><\/a><\/p>

Canale F. P., Basso C., Antonini, G., Perotti, M., Li, N., Sokolovska, A., Neumann, J., James, M. J., Geiger, S., Jin, W., Theurillat, J. P., West, K. A., Leventhal, D. S., Lora, J. M., Sallusto F. & Roger Geiger<\/p>

Doi: 10.1038\/s41586-021-04003-2<\/p>

A dedicated News & Views<\/em> is available here<\/a>. doi: 10.1038\/d41586-021-02639-8<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Left: Tumor growth curves of mice that received different therapeutic treatments. Right: Survival curves of mice.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Bellinzona, October 6th, 2021 \u2013 A Nature paper by the Systems Immunology group, headed by Roger Geiger, at the Institute for Research in Biomedicine (IRB, affiliated to USI). This study describes an innovative strategy to improve the anti-tumor activity of T cells, key players of the immune system with the ability to detect and kill […]<\/p>\n","protected":false},"author":4,"featured_media":25585,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"yoast_head":"\nEngineered bacteria for cancer immunotherapy - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/engineered-bacteria-for-cancer-immunotherapy\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Engineered bacteria for cancer immunotherapy - IRB USI\" \/>\n<meta property=\"og:description\" content=\"Bellinzona, October 6th, 2021 \u2013 A Nature paper by the Systems Immunology group, headed by Roger Geiger, at the Institute for Research in Biomedicine (IRB, affiliated to USI). 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