{"id":25398,"date":"2021-09-17T10:41:46","date_gmt":"2021-09-17T08:41:46","guid":{"rendered":"https:\/\/irb.usi.ch\/?p=25398"},"modified":"2021-09-17T11:30:50","modified_gmt":"2021-09-17T09:30:50","slug":"first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/news\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\/","title":{"rendered":"First peptide inhibitor of the CXCL12\/HMGB1 heterocomplex identified"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"25398\" class=\"elementor elementor-25398\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-afc7806 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"afc7806\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a67276d ae-bg-gallery-type-default\" data-id=\"a67276d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ba33c9d elementor-widget elementor-widget-text-editor\" data-id=\"ba33c9d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>During inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. The chemokine CXCL12 and the alarmin HMGB1, both released in the microenvironment, can form a heterocomplex, which exclusively acts on the chemokine receptor CXCR4, enhancing cell migration and, in some pathological conditions such as Rheumatoid Arthritis exacerbates the immune response.<\/p><p>A study performed by the\u00a0<strong><a href=\"https:\/\/irb.usi.ch\/computational-structural-biology\/\">Cavalli <\/a><\/strong>and <strong><a href=\"https:\/\/irb.usi.ch\/chemokines-in-immunity\/\">Uguccioni<\/a> <\/strong>labs\u00a0and published in the Journal of Medicinal Chemistry, reports about the identification and characterization of the first peptide inhibitor of the CXCL12\/HMGB1 heterocomplex.<\/p><p>In the study, computational methods have been used to identify a potent and selective ligand for HMGB1 (HBP08) at the binding site with CXCL12. Biophysical, structural biology techniques, and functional assays were used to fully characterize the effect of HBP08 on leukocyte migration, to confirm the inhibition of the activity of the heterocomplex.<\/p><p>This study represents an important step towards an effective pharmacological modulation of the CXCL12\/HMGB1 heterocomplex in inflammatory and autoimmune diseases.<\/p><p><strong>Article<\/strong><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34510899\/\"><strong>Systematic Development of Peptide Inhibitors Targeting the CXCL12\/HMGB1 Interaction<\/strong><\/a><strong>.<\/strong><\/p><p>Sgrignani, J., V. Cecchinato, E. M. A. Fassi, G. D&#8217;Agostino, M. Garofalo, G. Danelon, M. Pedotti, L. Simonelli, L. Varani, G. Grazioso, M. Uguccioni and A. Cavalli<\/p><p>J Med Chem. 2021, DOI: 10.1021\/acs.jmedchem.1c00852.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-e68f0a7 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"e68f0a7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b2a8b92 ae-bg-gallery-type-default\" data-id=\"b2a8b92\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c01b377 elementor-widget elementor-widget-image\" data-id=\"c01b377\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"421\" src=\"https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-1024x421.jpg\" class=\"attachment-large size-large wp-image-25403\" alt=\"\" srcset=\"https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-1024x421.jpg 1024w, https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-300x123.jpg 300w, https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-768x316.jpg 768w, https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-1536x632.jpg 1536w, https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-2048x842.jpg 2048w, https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-750x308.jpg 750w, https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2-1140x469.jpg 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>During inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. The chemokine CXCL12 and the alarmin HMGB1, both released in the microenvironment, can form a heterocomplex, which exclusively acts on the chemokine receptor CXCR4, enhancing cell migration and, in some pathological conditions such as Rheumatoid Arthritis exacerbates the [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":25399,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-25398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First peptide inhibitor of the CXCL12\/HMGB1 heterocomplex identified - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/news\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First peptide inhibitor of the CXCL12\/HMGB1 heterocomplex identified - IRB USI\" \/>\n<meta property=\"og:description\" content=\"During inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. The chemokine CXCL12 and the alarmin HMGB1, both released in the microenvironment, can form a heterocomplex, which exclusively acts on the chemokine receptor CXCR4, enhancing cell migration and, in some pathological conditions such as Rheumatoid Arthritis exacerbates the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/news\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-17T08:41:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-09-17T09:30:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/Sgrignani_Sept2021_JMedical_Chemistry2_slider.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"582\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Maryse\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Maryse\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\\\/\"},\"author\":{\"name\":\"Maryse\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/person\\\/1bdd6a1c070b712a183ecb2684c11bc8\"},\"headline\":\"First peptide inhibitor of the CXCL12\\\/HMGB1 heterocomplex identified\",\"datePublished\":\"2021-09-17T08:41:46+00:00\",\"dateModified\":\"2021-09-17T09:30:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\\\/\"},\"wordCount\":218,\"publisher\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/Sgrignani_Sept2021_JMedical_Chemistry2_slider.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\\\/\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/news\\\/first-peptide-inhibitor-of-the-cxcl12-hmgb1-heterocomplex-identified\\\/\",\"name\":\"First peptide inhibitor of the CXCL12\\\/HMGB1 heterocomplex identified - 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