{"id":21946,"date":"2020-08-19T17:12:09","date_gmt":"2020-08-19T15:12:09","guid":{"rendered":"https:\/\/irb.usi.ch\/?p=21946"},"modified":"2020-10-09T09:23:04","modified_gmt":"2020-10-09T07:23:04","slug":"trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/","title":{"rendered":"TRAD &#8211; Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"21946\" class=\"elementor elementor-21946 elementor-21463\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-91b6bd4 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"91b6bd4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44c7d1f ae-bg-gallery-type-default\" data-id=\"44c7d1f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e88d412 elementor-widget elementor-widget-text-editor\" data-id=\"e88d412\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>When our DNA breaks, cells use the homologous recombination pathway to accurately repair the break, so that DNA is fixed and no mutations are introduced during the repair process. When multiple DNA molecules are broken, the recombination factors use a smart strategy to join only the DNA pieces originating from the same DNA molecules. This is very important, because mistakes in this process can lead to uncontrolled growth and tumor formation. Therefore, the recombination machinery has evolved to be remarkably precise.<\/p><p>In contrast in specialized cells undergoing meiotic division, which includes spermatocytes and oocytes in humans, the homologous recombination has a different purpose. Meiotic cells induce DNA breaks deliberately, and use recombination to mix and match the DNA sequences between chromosomes coming from the previous generation (mum and dad). Like this, the organisms achieve new combination of genes, which did not exist before. Such a diversity is one of the drivers of evolution. The mix-matched genetic outcome is therefore almost the exact opposite to what happens in most other (non-meiotic) cells.<\/p><p>How can one pathway (homologous recombination) achieve such different outcomes? The answer is that the proteins that function in recombination in meiotic and non-meiotic cells are in part different. Specifically, a group of proteins, centered around the MLH1-MLH3 complex, function specifically in meiotic recombination. MLH1-MLH3, as well as MSH4-MSH5 and were found to be important for such a mix-matching of DNA &#8211; termed crossover formation. How exactly this happens was however not clear, and has been a long-standing interest of the Cejka laboratory at the Institute for Research in Biomedicine (IRB), affiliated to the Universit\u00e0 della Svizzera italiana (USI).<\/p><p>When recombination repairs broken DNA, the intermediates of the repair process are termed joint-molecules, structures that link both broken and not-broken DNA molecules. The trick, it seems, is how to cut these structures. Normal cells use strategies that separate the joint molecules in a way that the original composition is restored. Meiotic cells, instead, use MLH1-MLH3 to cut DNA in a way that produces the mix-matched DNA. A recent study from the Cejka laboratory, published in the journal of <em>Nature<\/em>, describes a possible mechanism for this DNA cleavage. Elda Cannavo, Aurore Sanchez and Roopesh Anand, the main authors who carried out the experimental work of the study, demonstrated that the DNA cleavage by MLH1-MLH3 is directed by a ring-like protein PCNA. PCNA is needed for DNA synthesis during recombination, and as DNA is synthesized on only one strand of the break, its asymmetric presence at the joint molecule recombination intermediates directs MLH1-MLH3 to cleave DNA in the configuration that produces crossovers.<\/p><p>Mutations in MLH1-MLH3 and associated factors lead to sterility in humans.<\/p><p>The study was funded by the Swiss National Science Foundation and the European Research Council. The research was carried out in collaboration with the ETH Zurich, University of Zurich, Curie Institute (FR), University of Sussex (UK) and University of Copenhagen (DK).<\/p><p><strong>Article<\/strong><\/p><p><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2592-2\" target=\"_blank\" rel=\"noopener\">Regulation of the MLH1-MLH3 endonuclease in meiosis<\/a><\/p><p>Elda Cannavo<sup>#<\/sup>, Aurore Sanchez<sup>#<\/sup>, Roopesh Anand<sup>#<\/sup>, Lepakshi Ranjha, Jannik Hugener, C\u00e9line Adam, Ananya Acharya, Nicolas Weyland, Xavier Aran-Guiu, Jean-Baptiste Charbonnier, Eva R. Hoffmann, Val\u00e9rie Borde, Joao Matos and Petr Cejka<\/p><p>DOI: 10.1038\/s41586-020-2592-2<\/p><p><sup>#<\/sup> These authors contributed equally<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>TRAD &#8211; When our DNA breaks, cells use the homologous recombination pathway to accurately repair the break, so that DNA is fixed and no mutations are introduced during the repair process. When multiple DNA molecules are broken, the recombination factors use a smart strategy to join only the DNA pieces originating from the same DNA [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":21949,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[52],"tags":[],"class_list":["post-21946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TRAD - Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TRAD - Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab - IRB USI\" \/>\n<meta property=\"og:description\" content=\"TRAD &#8211; When our DNA breaks, cells use the homologous recombination pathway to accurately repair the break, so that DNA is fixed and no mutations are introduced during the repair process. When multiple DNA molecules are broken, the recombination factors use a smart strategy to join only the DNA pieces originating from the same DNA [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-19T15:12:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-09T07:23:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/Cejka_Nature_paper_August2020_large.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"447\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"AD_Dave\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"AD_Dave\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/\"},\"author\":{\"name\":\"AD_Dave\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/person\\\/c9b66c69925e1b0c558072acbadf4156\"},\"headline\":\"TRAD &#8211; Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab\",\"datePublished\":\"2020-08-19T15:12:09+00:00\",\"dateModified\":\"2020-10-09T07:23:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/\"},\"wordCount\":559,\"publisher\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/Cejka_Nature_paper_August2020_large.jpg\",\"articleSection\":[\"Notizie\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/\",\"name\":\"TRAD - Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab - IRB USI\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/Cejka_Nature_paper_August2020_large.jpg\",\"datePublished\":\"2020-08-19T15:12:09+00:00\",\"dateModified\":\"2020-10-09T07:23:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/#primaryimage\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/Cejka_Nature_paper_August2020_large.jpg\",\"contentUrl\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/Cejka_Nature_paper_August2020_large.jpg\",\"width\":640,\"height\":447},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/notizie\\\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"home-slider\",\"item\":\"https:\\\/\\\/irb.usi.ch\\\/.\\\/home-slider\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"TRAD &#8211; Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#website\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"publisher\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#organization\",\"name\":\"IRB USI\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/IRB-Usi.svg\",\"contentUrl\":\"https:\\\/\\\/irb.usi.ch\\\/images\\\/IRB-Usi.svg\",\"width\":98,\"height\":43,\"caption\":\"IRB USI\"},\"image\":{\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/irb.usi.ch\\\/it\\\/#\\\/schema\\\/person\\\/c9b66c69925e1b0c558072acbadf4156\",\"name\":\"AD_Dave\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"TRAD - Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab - IRB USI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/","og_locale":"it_IT","og_type":"article","og_title":"TRAD - Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab - IRB USI","og_description":"TRAD &#8211; When our DNA breaks, cells use the homologous recombination pathway to accurately repair the break, so that DNA is fixed and no mutations are introduced during the repair process. When multiple DNA molecules are broken, the recombination factors use a smart strategy to join only the DNA pieces originating from the same DNA [&hellip;]","og_url":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/","og_site_name":"IRB USI","article_published_time":"2020-08-19T15:12:09+00:00","article_modified_time":"2020-10-09T07:23:04+00:00","og_image":[{"width":640,"height":447,"url":"https:\/\/irb.usi.ch\/images\/Cejka_Nature_paper_August2020_large.jpg","type":"image\/jpeg"}],"author":"AD_Dave","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"AD_Dave","Tempo di lettura stimato":"3 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/#article","isPartOf":{"@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/"},"author":{"name":"AD_Dave","@id":"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156"},"headline":"TRAD &#8211; Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab","datePublished":"2020-08-19T15:12:09+00:00","dateModified":"2020-10-09T07:23:04+00:00","mainEntityOfPage":{"@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/"},"wordCount":559,"publisher":{"@id":"https:\/\/irb.usi.ch\/it\/#organization"},"image":{"@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/#primaryimage"},"thumbnailUrl":"https:\/\/irb.usi.ch\/images\/Cejka_Nature_paper_August2020_large.jpg","articleSection":["Notizie"],"inLanguage":"it-IT"},{"@type":"WebPage","@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/","url":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/","name":"TRAD - Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab - IRB USI","isPartOf":{"@id":"https:\/\/irb.usi.ch\/it\/#website"},"primaryImageOfPage":{"@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/#primaryimage"},"image":{"@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/#primaryimage"},"thumbnailUrl":"https:\/\/irb.usi.ch\/images\/Cejka_Nature_paper_August2020_large.jpg","datePublished":"2020-08-19T15:12:09+00:00","dateModified":"2020-10-09T07:23:04+00:00","breadcrumb":{"@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/"]}]},{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/#primaryimage","url":"https:\/\/irb.usi.ch\/images\/Cejka_Nature_paper_August2020_large.jpg","contentUrl":"https:\/\/irb.usi.ch\/images\/Cejka_Nature_paper_August2020_large.jpg","width":640,"height":447},{"@type":"BreadcrumbList","@id":"https:\/\/irb.usi.ch\/it\/notizie\/trad-regulation-of-the-mlh1-mlh3-endonuclease-in-meiosis-a-nature-paper-by-the-cejka-lab\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/irb.usi.ch\/it\/"},{"@type":"ListItem","position":2,"name":"home-slider","item":"https:\/\/irb.usi.ch\/.\/home-slider\/"},{"@type":"ListItem","position":3,"name":"TRAD &#8211; Regulation of the MLH1-MLH3 endonuclease in meiosis: a Nature paper by the Cejka Lab"}]},{"@type":"WebSite","@id":"https:\/\/irb.usi.ch\/it\/#website","url":"https:\/\/irb.usi.ch\/it\/","name":"IRB USI","description":"Institute for Research in Biomedicine","publisher":{"@id":"https:\/\/irb.usi.ch\/it\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/irb.usi.ch\/it\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/irb.usi.ch\/it\/#organization","name":"IRB USI","url":"https:\/\/irb.usi.ch\/it\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/irb.usi.ch\/it\/#\/schema\/logo\/image\/","url":"https:\/\/irb.usi.ch\/images\/IRB-Usi.svg","contentUrl":"https:\/\/irb.usi.ch\/images\/IRB-Usi.svg","width":98,"height":43,"caption":"IRB USI"},"image":{"@id":"https:\/\/irb.usi.ch\/it\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/c9b66c69925e1b0c558072acbadf4156","name":"AD_Dave"}]}},"_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/21946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=21946"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/21946\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media\/21949"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=21946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=21946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=21946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}