{"id":21900,"date":"2020-10-06T14:58:43","date_gmt":"2020-10-06T12:58:43","guid":{"rendered":"https:\/\/irb.usi.ch\/irb-community\/the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/"},"modified":"2021-04-20T18:01:46","modified_gmt":"2021-04-20T16:01:46","slug":"tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling","status":"publish","type":"post","link":"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/","title":{"rendered":"The role of beta-arrestins in CXCL12\/HMGB1-mediated signaling"},"content":{"rendered":"<p>The ability of chemokines to form heterocomplexes with other chemokines or HMGB1 represents an additional level of regulation for shaping their function by enhancing their potency on their cognate receptor. In recent years, the relevance of the CXCL12\/HMGB1 heterocomplex activity, on the chemokine receptor CXCR4, has been widely demonstrated in models of inflammation and tissue regeneration, and in human pathological conditions.<\/p>\n<p>Our disclosure of the activity of the CXCL12\/HMGB1 heterocomplex in Rheumatoid Arthritis, and the fact that it induces a different conformational change in CXCR4 dimers compared to stimulation with CXCL12 alone, prompted us to further investigate the downstream signalling events elicited by CXCR4 triggering.<\/p>\n<p>In the current work, we demonstrate that the CXCL12\/HMGB1 heterocomplex is a balanced agonist for CXCR4, promoting a prompt availability of CXCR4 on the cell surface, and enhancing directional cell migration. These data unveil the signalling induced by the CXCL12\/HMGB1 heterocomplex in view of identifying biased antagonists targeting the heterocomplex selective pathways, leaving unaltered the beneficial activity of CXCL12, in order to improve therapies in pathologic conditions. Moreover, the knowledge of the signalling pathways elicited by the heterocomplex could be also relevant in understanding how to foster a CXCR4 signalling able to induce tissue regeneration.<\/p>\n<p><strong>Article<\/strong><\/p>\n<p><a href=\"http:\/\/doi.org\/10.3389\/fimmu.2020.550824\">\u03b2-Arrestin1 and \u03b2-Arrestin2 Are Required to Support the Activity of the CXCL12\/HMGB1 Heterocomplex on CXCR4<\/a>.<\/p>\n<p>D\u2019Agostino, G., M. Artinger, M. Locati, L. Perez, D. F. Legler, M. E. Bianchi, C. R\u00fcegg, M. Thelen, A. Marchese, M. B. L. Rocchi, V. Cecchinato and M. Uguccioni<\/p>\n<p>Frontiers in Immunology. 2020; 11: DOI: 10.3389\/fimmu.2020.550824<\/p>\n<p><img loading=\"lazy\" src=\"https:\/\/irb.usi.ch\/images\/\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020-1024x656.jpg\" sizes=\"(max-width: 800px) 100vw, 800px\" srcset=\"https:\/\/irb.usi.ch\/images\/\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020-1024x656.jpg 1024w, https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020-300x192.jpg 300w, https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020-768x492.jpg 768w, https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020-1536x983.jpg 1536w, https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020-750x480.jpg 750w, https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020-1140x730.jpg 1140w, https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020.jpg 1854w\" alt=\"\" width=\"800\" height=\"513\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The ability of chemokines to form heterocomplexes with other chemokines or HMGB1 represents an additional level of regulation for shaping their function by enhancing their potency on their cognate receptor. In recent years, the relevance of the CXCL12\/HMGB1 heterocomplex activity, on the chemokine receptor CXCR4, has been widely demonstrated in models of inflammation and tissue [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":21901,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[52],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The role of beta-arrestins in CXCL12\/HMGB1-mediated signaling - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The role of beta-arrestins in CXCL12\/HMGB1-mediated signaling - IRB USI\" \/>\n<meta property=\"og:description\" content=\"The ability of chemokines to form heterocomplexes with other chemokines or HMGB1 represents an additional level of regulation for shaping their function by enhancing their potency on their cognate receptor. In recent years, the relevance of the CXCL12\/HMGB1 heterocomplex activity, on the chemokine receptor CXCR4, has been widely demonstrated in models of inflammation and tissue [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-06T12:58:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-20T16:01:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1854\" \/>\n\t<meta property=\"og:image:height\" content=\"1187\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\">\n\t<meta name=\"twitter:data1\" content=\"2 minuti\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/irb.usi.ch\/it\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"it-IT\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/#primaryimage\",\"inLanguage\":\"it-IT\",\"url\":\"https:\/\/irb.usi.ch\/images\/Graphycal-Abstract_FrontiersImmunol_MGU_September2020.jpg\",\"width\":1854,\"height\":1187},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/#webpage\",\"url\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/\",\"name\":\"The role of beta-arrestins in CXCL12\/HMGB1-mediated signaling - IRB USI\",\"isPartOf\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/#primaryimage\"},\"datePublished\":\"2020-10-06T12:58:43+00:00\",\"dateModified\":\"2021-04-20T16:01:46+00:00\",\"author\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/1bdd6a1c070b712a183ecb2684c11bc8\"},\"breadcrumb\":{\"@id\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/.\/notizie\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/.\/notizie\/\",\"name\":\"Notizie\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/\",\"url\":\"https:\/\/irb.usi.ch\/it\/notizie\/tradotto-the-role-of-beta-arrestins-in-cxcl12-hmgb1-mediated-signaling\/\",\"name\":\"The role of beta-arrestins in CXCL12\/HMGB1-mediated signaling\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/irb.usi.ch\/it\/#\/schema\/person\/1bdd6a1c070b712a183ecb2684c11bc8\",\"name\":\"Maryse\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/21900"}],"collection":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/comments?post=21900"}],"version-history":[{"count":0,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/posts\/21900\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media\/21901"}],"wp:attachment":[{"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/media?parent=21900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/categories?post=21900"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irb.usi.ch\/it\/wp-json\/wp\/v2\/tags?post=21900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}