{"id":22350,"date":"2019-07-12T14:39:45","date_gmt":"2019-07-12T12:39:45","guid":{"rendered":"https:\/\/irb.usi.ch\/?page_id=22350"},"modified":"2026-05-15T11:53:02","modified_gmt":"2026-05-15T09:53:02","slug":"immunologia-mucosale","status":"publish","type":"page","link":"https:\/\/irb.usi.ch\/it\/immunologia-mucosale\/","title":{"rendered":"Immunologia mucosale"},"content":{"rendered":"\t\t
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Interazioni tra microbioma e immunit\u00e0<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Panoramica<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Il microbiota svolge un ruolo critico per la salute e le malattie umane. Tuttavia, il modo in cui l’ospite e il microbiota interagiscono e come questo contribuisca allo sviluppo delle malattie \u00e8 ancora in gran parte sconosciuto. L’obiettivo generale del nostro gruppo \u00e8 identificare e studiare i meccanismi molecolari specifici attraverso cui i microbi influenzano l’ospite, inclusi i modi in cui i batteri commensali modulano l’immunit\u00e0 dell’ospite e come questo, a sua volta, impatti sulla malattia. Siamo particolarmente interessati alle risposte immunitarie nel polmone, compresa la risposta a patogeni respiratori come il virus dell’influenza e a malattie croniche come la fibrosi polmonare idiopatica e il diabete. In particolare, il nostro obiettivo \u00e8 caratterizzare il ruolo del microbiota intestinale e polmonare e dei suoi prodotti nel controllo del sistema immunitario dell’ospite e come questo contribuisca all’infiammazione delle vie aeree in diversi contesti patologici. Questo include fattori che hanno un impatto diretto sul microbiota, come l’alimentazione e altre influenze ambientali. Per raggiungere i nostri obiettivi, impieghiamo metodi OMICS all’avanguardia per descrivere la complessit\u00e0 del microbiota e dei suoi prodotti e utilizziamo modelli murini gnotobiotici avanzati in vivo e sistemi organoidi traslazionali in vitro per stabilire il ruolo meccanicistico e funzionale di specifici microbi nella regolazione del sistema immunitario umano.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Group Leader<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Samuel Nobs<\/strong>
samuel.nobs@irb.usi.ch<\/a>
+41 58 666 7225<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Pubblicazioni<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ricercatori<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Emanuela Adrovic<\/span><\/a>
Alina Astourian<\/span><\/a>
Matteo Brozzoni<\/span><\/a>
Ugne Ceplaite<\/span><\/a>
Silvia Fattore<\/span><\/a>
Lara Hernandez Ag\u00fcero<\/span><\/a>
Marcela Agata Hunderuk<\/span><\/a>
Federica Pietrosanti<\/span><\/a>
Paola Pinco<\/a><\/span>
Kateryna Pryimak<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Progetti<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigating host microbiota interactions in lung fibrosis<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Researchers:<\/strong>
Samuel Nobs<\/span>\u00a0– Group Leader<\/p>

Status:\u00a0<\/strong>in progress<\/p><\/section>

Overview<\/strong><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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Investigating host microbiota interactions in lung fibrosis<\/p>

Researchers:<\/strong>
Samuel Nobs <\/u>– Group Leader<\/p>

Status: <\/strong>in progress<\/p><\/section>

Overview<\/strong><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Interazioni tra microbioma e immunit\u00e0 Panoramica Il microbiota svolge un ruolo critico per la salute e le malattie umane. Tuttavia, il modo in cui l’ospite e il microbiota interagiscono e come questo contribuisca allo sviluppo delle malattie \u00e8 ancora in gran parte sconosciuto. L’obiettivo generale del nostro gruppo \u00e8 identificare e studiare i meccanismi molecolari […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-22350","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nImmunologia mucosale - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/immunologia-mucosale\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunologia mucosale - IRB USI\" \/>\n<meta property=\"og:description\" content=\"Interazioni tra microbioma e immunit\u00e0 Panoramica Il microbiota svolge un ruolo critico per la salute e le malattie umane. 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