{"id":22349,"date":"2019-07-12T14:34:26","date_gmt":"2019-07-12T12:34:26","guid":{"rendered":"https:\/\/irb.usi.ch\/?page_id=22349"},"modified":"2026-02-19T10:34:01","modified_gmt":"2026-02-19T08:34:01","slug":"immunologia-molecolare","status":"publish","type":"page","link":"https:\/\/irb.usi.ch\/it\/immunologia-molecolare\/","title":{"rendered":"Immunologia Molecolare"},"content":{"rendered":"\t\t
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Immunologia Molecolare<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Panoramica<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Il nostro gruppo \u00e8 interessato allo studio dei meccanismi trascrizionali e post-trascrizionali di regolazione dell’espressione genica nelle cellule del sistema immunitario. L’obiettivo \u00e8 quello di ampliare le nostre conoscenze sui meccanismi che regolano il differenziamento, la proliferazione e le funzioni delle cellule immunitarie e di svelare le reti di interazione tra modificazioni epigenetiche, fattori trascrizionali, microRNA (miRNA) e i loro bersagli.<\/p>

Le modificazioni epigenetiche ed epitrascrittomiche sono modifiche covalenti del DNA genomico e dell’mRNA che contribuiscono alla regolazione dell’espressione genica. Ad esempio, abbiamo scoperto che la delezione di Dnmt3a, un enzima responsabile della metilazione del DNA, porta all’iperattivazione delle cellule del sistema immunitario, che a sua volta pu\u00f2 portare al danneggiamento dei tessuti e all\u2019insorgenza di malattie (Leoni C. et al. PNAS 2017). In generale, siamo interessati a scoprire meccanismi che da un lato sono importanti per il corretto funzionamento delle cellule immunitarie, ma dall’altro possono portare a un’eccessiva proliferazione cellulare o a risposte inappropriate e dannose, ad esempio nel contesto delle malattie autoimmuni (Emming, Bianchi, Polletti et al. Nature Immunology 2020; Chirichella, Bianchi, Dzafo et al. PLoS Biology 2022).<\/p>

Attualmente siamo interessati ai meccanismi di regolazione post-trascrizionale che coinvolgono la metilazione dell’RNA e le proteine che legano l’RNA, nonch\u00e9 alla comprensione del meccanismo d’azione dei fattori di trascrizione che sono specificamente associati alle risposte infiammatorie delle cellule T.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Group Leader<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Silvia Monticelli<\/strong><\/a>
silvia.monticelli@irb.usi.ch<\/a>
+41 58 666 7124<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Pubblicazioni<\/span><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ricercatori<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Mara Cetty Spinella<\/a><\/span>\u00a0
Andrea Cavenaghi<\/span><\/a>\u00a0
Mathilda Rose Josephine Corcoles<\/a><\/span>
Cristina Leoni<\/a>
Roberta Marzi<\/a>
Amirali Mahour<\/a><\/span>
Mehrpouya Mostanfar<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Progetti<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Researchers<\/strong>
Mara Cetty Spinella<\/a><\/span> – Post-doc
<\/span>Roberta Marzi<\/a> – Scientist
<\/span>Samuele Mauri<\/a> – Pre-doc student
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Status: <\/strong>in progress
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Overview<\/strong><\/p><\/section>

Genome-wide association studies (GWAS) have identified over hundreds of genetic loci that are linked to a risk of autoimmune disease. There is now a pressing need to link disease-associated variants to biological functions, and to identify how genetic variants associated with the risk of disease contribute to disease and\/ or response to treatment. We are currently studying one of these loci in the context of inflammatory bowel disease. Support for this project is provided by the SNSF.<\/p><\/section><\/section><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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Researchers<\/strong>
Elena Foli<\/a>\u00a0– PhD student
Mehrpouya Mostanfar\u00a0–<\/a>\u00a0PhD student<\/p>

Status:\u00a0<\/strong>in progress
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Overview<\/strong><\/p>

Following up on previous work from our lab (Emming, Bianchi, Polletti et al. Nature Immunology 2020), that identified specific transcription factors and signaling molecules associated to a highly pro-inflammatory and potentially pathogenic phenotype of human T lymphocytes, we are now investigating how some of these factors are regulated in humans and may be associated to disease, especially in the context of autoimmunity. Support for this project is provided by a SNSF Excellence Grant and by the Ceresio Foundation Lugano<\/p><\/section><\/section><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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Researchers<\/strong>
Cristina Leoni<\/a><\/span> – Scientist
Mathilda Corcoles<\/a> <\/span>– PhD student
Roberta Marzi<\/a> <\/span> – PhD student<\/p>

Status: <\/strong>in progress
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Overview<\/strong><\/p><\/section>

The general aim is to understand how post-transcriptional regulatory mechanisms mediated by RNA-binding proteins (RBPs) affect immune cell responses. Currently, we are focusing on selected classes of RBPs to determine their role in restraining inflammatory responses primarily in human T lymphocytes. Support for this project is provided by the Comel Foundation Lugano<\/p><\/section><\/section><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Immunologia Molecolare Panoramica Il nostro gruppo \u00e8 interessato allo studio dei meccanismi trascrizionali e post-trascrizionali di regolazione dell’espressione genica nelle cellule del sistema immunitario. L’obiettivo \u00e8 quello di ampliare le nostre conoscenze sui meccanismi che regolano il differenziamento, la proliferazione e le funzioni delle cellule immunitarie e di svelare le reti di interazione tra modificazioni […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-22349","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nImmunologia Molecolare - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irb.usi.ch\/it\/immunologia-molecolare\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunologia Molecolare - IRB USI\" \/>\n<meta property=\"og:description\" content=\"Immunologia Molecolare Panoramica Il nostro gruppo \u00e8 interessato allo studio dei meccanismi trascrizionali e post-trascrizionali di regolazione dell’espressione genica nelle cellule del sistema immunitario. 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